Full-Thickness Rectal Prolapse in children: Sclerotherapy versus Lockhart Mummery Rectopexy

Introduction: Rectal prolapse is a relatively common disorder in childhood. In this phenomenon, the whole layers of the rectum protrude throughout the anus. Self-limiting cases of rectal prolapse are more common in children below four years old, and overall prevalence is higher in the first year of life, with a predominance of male children. Formerly, the therapeutic efforts insisted on surgery. Nowadays, noninvasive methods like Sclerotherapy have entered the arena. Materials and Methods: This study aimed to compare the efficacy and postoperative complications of 56 children suffering from full-thickness rectal prolapse retrospectively randomized in two groups of conventional surgery and Sclerotherapy referring to the Mofid children's hospital from 2017 to 2020. The authors have used Lockhart mummery rectopexy and Sclerotherapy methods with hypertonic dextrose 50%. Results: Our results revealed a statistically significant difference in mean hospital stay (P-value <0.0001) and follow-up time (P-value=0.009) in the sclerotherapy group compared to other group, but surgical complications (P-value=0.58) and recurrence rate (P-value= 0.62) were statistically non-significant in both groups. Conclusion: careful selection of patients based on symptoms has a vital role in the success of the chosen method for treating rectal prolapse in children. &nbsp

Clinical Characteristics and Mortality of a Hospitalized 13 Years Old Patient with Covid-19: A Case Report

The corona virus is a global problem that threatens human life. According to the latest data from different countries the mortality of this virus in children is less than adult. A 13-year-old girl was hospitalized for 6 months following a gunshot trauma and its complications. When her general condition was finally improving, she was diagnosed with the corona virus and passed away. Children who are suffering from underlying diseases and need medical care are at a higher risk of death from the corona virus

An improved method for injection of bolus doses of drugs into the perfusion circuit of isolated perfused rat kidney utilizing a six-port injection valve

The isolated perfused rat kidney experiment was introduced in 1959 for studying the regulation of renal blood flow and is recognized as a valuable preparation for studying physiological and biochemical aspects of renal function such as hemodynamics, glomerular filtration rate (GFR) and overall handling of fluids. Dose-response curves are obtained by injection of bolus doses of drugs into the perfusion line. However current injection methods can cause several problems such as low reproducibility and altered baseline pressure. The aim of the present work is to develop a simple method of introducing the drug into the perfusion circuit which is free from these aberrations. This was achieved using a six-way injection valve placed in the perfusion circuit, just before the kidney. To assess the reproducibility of this method, 400 μL epinephrine (10-7 M) was injected seven times into an isolated perfused rat kidney. The mean peak pressure rise (mmHg) was 30.3±0.6, 28.5±0.8 and 27.1±0.6 at 100, 120 and 140 mmHg base perfusion pressures respectively. Base pressure returned to pre-injection levels under all conditions tested. Low standard deviation of pressure maxima indicates the high reproducibility of this method while multiple injections can be made in a relatively shorter time. This method can be applied to all organ perfusion setups such as isolated hind limb, tail, arteries and arterioles

U100: An Innovative USERN Platform for Education and Research Without Borders

The article's abstract is no available