What are the hemodynamic and respiratory effects of passive limb exercise for mechanically ventilated patients receiving low-dose vasopressor/inotropic support?

Passive limb exercises (PLEs) are used widely in the management of unconscious patients and an early start is recommended. The aim of this study was to determine the effects of PLEs on hemodynamic and respiratory parameters in mechanically ventilated critically ill patients receiving low-dose vasopressor/inotropic support. The charts of 120 mechanically ventilated patients who underwent PLEs were evaluated retrospectively between January 2000 and July 2002. Patients were grouped on the basis of administration of vasopressor/inotropic support. Thirty-eight patients did not get vasopressor/inotropic support (group 1) and 82 patients received low-dose vasopressor/inotropic support (dopamine .05). This retrospective study confirmed that PLEs result in similar hemodynamic and respiratory changes in critically ill patients who received low-dose vasopressor/inotropic support versus those who do not. Copyright © 2014 Lippincott Williams & Wilkins

Comparison of the effectiveness of pretreatment by fentanyl and remifentanil on rocuronium induced injection pain

Objectives: To compare the efficacy of fentanyl and remifentanil as prodrugs in the prevention of rocuronium injection pain by using a control group

Day-Time Isoflurane Administration Suppresses Circadian Gene Expressions in Both the Brain and a Peripheral Organ, Liver

Objective: The aim of this study is to investigate the effects of light and administration time of isoflurane on circadian gene expression in the brains and liver tissues of rats kept in light-dark cycle

A cross-over, post-electroconvulsive therapy comparison of clinical recovery from rocuronium versus succinylcholine

Study Objective: To evaluate the effect of the neuromuscular blocking agent, rocuronium, oil clinical recovery from electroconvulsive therapy (ECT) as compared With succinylcholine

Neuroprotective effects of ketorolac tromethamine after spinal cord injury in rats: an ultrastructural study

Introduction: The aim of this study was to investigate the effects of intrathecally administered ketorolac tromethamine on ultrastructural changes of the spinal cord in spinal cord-traumatised rats

Comparison of the effects of 2 different doses of remifentanil infusion for sedation during in-vitro fertilization procedure.

Objectives: To compare the sedation level, hemodynamic effects, patient and physician satisfactions following sedation achieved by 2 different doses of remifentanil (R) infusion with additional bolus infusions of propofol for in vitro fertilization (IVF) procedure

Evaluation of the Effectiveness of Sugammadex for Verapamil Intoxication

Previous studies have shown that medications from the cyclodextrin family bind to verapamil. The aim of our study was to determine whether sugammadex could bind to verapamil and prevent the cardiovascular toxicity of that drug. Twenty-eight sedated Wistar rats were infused with verapamil at 37.5mg/kg/h. Five minutes after the start of infusion, the animals were treated with a bolus of either 16mg/kg, 100mg/kg or 1000mg/kg sugammadex. The control group was treated with an infusion without sugammadex. The heart rate and respiratory rate were monitored, and an electrocardiogram was recorded. The primary end-point was the time to asystole. The verapamil infusion continued until the animals arrested. The asystole time for the S16 group was significantly longer compared to those for the control and S1000 groups (p<0.05). The asystole time for the S1000 group was significantly shorter than those for all of the other groups (p<0.05). Reflecting these data, there was a near doubling of the mean lethal dose of verapamil from 13.57mg/kg (S.D. +/- 8.1) in the saline-treated rats to 22.42mg/kg (S.D. +/- 9.9) in the sugammadex 16 group (p<0.05). However, for the sugammadex 1000 group, the mean lethal dose was found to be 6.28 +/- 1.11mg/kg. This dose is significantly lower than those for all of the other groups (p<0.05). We found that treatment with 16mg/kg sugammadex delayed verapamil cardiotoxicity in rats. However, 1000mg/kg sugammadex accelerated verapamil cardiotoxicity in rats. Further studies must be conducted to investigate the interaction between verapamil and sugammadex

Comparison of meperidine plus midazolam and fentanyl plus midazolam in procedural sedation: A double-blind, randomized controlled trial

This double-blind, randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department. Seventy consecutive adult patients with fractures or dislocations suitable for reduction were randomized to receive fentanyl (1 mcg/kg; n=36) or meperidine (0.5 mg/kg; n=34) in combination with midazolam (0.02 mg/kg). Vital signs and alertness scale scores of the patients were monitored. The Visual Analog Scale (VAS) was used to determine the degree of pain. There was no statistically significant difference between the VAS mean scores of the fentanyl and meperidine groups (t test, P=.772). The need for additional analgesic drugs was significantly more frequent in patients receiving meperidine (P=.018). No adverse events, such as hypotension or respiratory depression, were noted. Euphoria occurred in one patient in the fentanyl group. Although dose requirements differ, fentanyl and meperidine provide effective and reliable analgesia in closed reduction of fractures and dislocations