1,008 research outputs found

    Wirausaha Produktif Berbasis Sektor Unggulan Desa Senyiur Lombok Timur

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    Pengabdian ini dilakukan karena berangkat dari tiga kondisi yang dihadapi kelompok sasaran (kelompok usia produktif, anak putus sekolah/tidak melanjutkan studi, buat aksara), yaitu: (1) lemahnya skill dalam menghasilkan produk berbasis keunggulan wilayah, padahal potensi keunggulan sangat potensial baik dibidang pertaninan, peternakan, perdagangan, kerajinan, jasa, dan lainnya; (2) belum memadainya kemampuan dalam pengelolaan usaha berbasis keunggulan wilayah, baik tata kelola keuangan, tata kelola kelembagaan, manajemen sumber daya, maupun lainnya; dan (3) belum memadainya kemampuan dalam memasarkan produk termasuk strategi bersaing. Kondisi ini berimplikasi terhadap pendapatan yang masih rendah, daya beli masyarakat, produktivitas, dan angka kemiskinan yang masih tinggi. Oleh karenanya, pengabdian ini dilakukan dengan tujuan untuk memperkuat kompetensi kelompok sasaran dalam mengembangkan usaha ekonomi produktif berbasis sektor unggulan wilayah.  Untuk mewujudkan tujuan tersebut, maka solusi yang ditawarkan adalah berupa kegiatan pelatihan dan pendampingan wirausaha produktif pada tiga aspek sekaligus, yaitu: pengembangan produk, pengelolaan usaha, dan pemasaran. Pelaksanaan pelatihan dan pendampingan dilakukan melalui kaji tindak partisipatif dengan pendekatan andragogis yang mengedepankan brainstorming dan praktik. Hasil pengabdian menunjukkan bahwa kelompok sasarn memliki kompetensi yang memadai dalam mengembangkan wirausaha produktif, khususnya dalam bidang peternakan dan pengolahan makanan hasil pertanian.  Hasil pendampingan juga menunjukkan adanya ada 1 (satu) kelompok peternak yang sudah mengimplementasikan hasil pelatihan disamping 1 (satu) kelompok yang mengembangkan pengolahan makanan hasil pertanian. Dibalik capaian tersebut, hal yang perlu diapresiasi adalah adanya keinginan, semangat, dan motivasi kelompok sasaran untuk mengembangkan usaha produktif.Kata Kunci: Wirausaha Produktif, Unggulan Des

    Access and utilisation of primary health care services comparing urban and rural areas of Riyadh Providence, Kingdom of Saudi Arabia

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    The Kingdom of Saudi Arabia (KSA) has seen an increase in chronic diseases. International evidence suggests that early intervention is the best approach to reduce the burden of chronic disease. However, the limited research available suggests that health care access remains unequal, with rural populations having the poorest access to and utilisation of primary health care centres and, consequently, the poorest health outcomes. This study aimed to examine the factors influencing the access to and utilisation of primary health care centres in urban and rural areas of Riyadh province of the KSA

    Evaluation and prediction of groundwater quality for irrigation using an integrated water quality indices, machine learning models and GIS approaches: a representative case study

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    Agriculture has significantly aided in meeting the food needs of growing population. In addition, it has boosted economic development in irrigated regions. In this study, an assessment of the groundwater (GW) quality for agricultural land was carried out in El Kharga Oasis, Western Desert of Egypt. Several irrigation water quality indices (IWQIs) and geographic information systems (GIS) were used for the modeling development. Two machine learning (ML) models (i.e., adaptive neuro-fuzzy inference system (ANFIS) and support vector machine (SVM)) were developed for the prediction of eight IWQIs, including the irrigation water quality index (IWQI), sodium adsorption ratio (SAR), soluble sodium percentage (SSP), potential salinity (PS), residual sodium carbonate index (RSC), and Kelley index (KI). The physicochemical parameters included T°, pH, EC, TDS, K+, Na+, Mg2+, Ca2+, Cl−, SO42−, HCO3−, CO32−, and NO3−, and they were measured in 140 GW wells. The hydrochemical facies of the GW resources were of Ca-Mg-SO4, mixed Ca-Mg-Cl-SO4, Na-Cl, Ca-Mg-HCO3, and mixed Na-Ca-HCO3 types, which revealed silicate weathering, dissolution of gypsum/calcite/dolomite/ halite, rock–water interactions, and reverse ion exchange processes. The IWQI, SAR, KI, and PS showed that the majority of the GW samples were categorized for irrigation purposes into no restriction (67.85%), excellent (100%), good (57.85%), and excellent to good (65.71%), respectively. Moreover, the majority of the selected samples were categorized as excellent to good and safe for irrigation according to the SSP and RSC. The performance of the simulation models was evaluated based on several prediction skills criteria, which revealed that the ANFIS model and SVM model were capable of simulating the IWQIs with reasonable accuracy for both training “determination coefficient (R2)” (R2 = 0.99 and 0.97) and testing (R2 = 0.97 and 0.76). The presented models’ promising accuracy illustrates their potential for use in IWQI prediction. The findings indicate the potential for ML methods of geographically dispersed hydrogeochemical data, such as ANFIS and SVM, to be used for assessing the GW quality for irrigation. The proposed methodological approach offers a useful tool for identifying the crucial hydrogeochemical components for GW evolution assessment and mitigation measures related to GW management in arid and semi-arid environments

    The Role of p300 Histone Acetyltransferase in UV-Induced Histone Modifications and MMP-1 Gene Transcription

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    Matrix metalloproteinase (MMP)-1 promotes ultraviolet (UV)-triggered long-term detrimental effects such as cancer formation and premature skin aging. Although histone modifications may play a crucial role in the transcriptional regulation of MMP-1, the relationship between UV-induced histone modification and MMP-1 expression is not completely understood. Here, we identify regulators of histone acetylation that may link UV-mediated DNA damage and MMP-1 induction by UV in cultured human dermal fibroblasts (HDFs) in vitro. UV irradiation of HDFs induced MMP-1 expression and increased the level of phosphorylation of H2AX (γ-H2AX), p53 and the acetylation of histone H3 (acetyl-H3). Total histone deacetylase (HDAC) enzymatic activity was decreased by UV irradiation, while histone acetyltransferase (HAT) activity was increased. Suppression of p300 histone acetyltransferase (p300HAT) activity by the p300HAT inhibitor anacardic acid (AA) or by down-regulation of p300 by siRNA prevented UV-induced MMP-1 expression and inhibited UV-enhanced γ-H2AX, p53 level, and acetyl-H3. Using chromatin immunoprecipitation assays, we observed that γ-H2AX, p53, acetyl-H3, p300 and c-Jun were consistently recruited by UV to a distinct region (−2067/−1768) adjacent to the p300 binding site (−1858/−1845) in the MMP-1 promoter. In addition, these recruitments of γ-H2AX, p53, acetyl-H3, p300 and c-Jun to the p300-2 site were significantly abrogated by post-treatment with AA. Furthermore, overexpression of p300 increased the basal and UV-induced MMP-1 promoter activity. Our results suggest that p300HAT plays a critical role in the transcriptional regulation of MMP-1 by UV
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