RMSE at short time scale over HP and QT series.

<p>RMSE mean (plus standard deviation) assessed at short time scale (i.e. τ = 1) over HP series, RMSE_{HP,τ = 1} (a,c,e), and QT series, RMSE_{QT,τ = 1} (b,d,f), is shown as a function of the experimental protocol. RMSE_{HP,τ = 1} and RMSE_{QT,τ = 1} are depicted as a function of the group of subjects in the NMC-MC protocol in (a) and (b) respectively, as a function of the period of analysis in the DAY-NIGHT protocol in (c) and (d) respectively, and as a function of the therapy in the BBoff-BBon protocol in (e) and (f) respectively. The gray, dark and white bars are relevant to NMC, ASYMP and SYMP individuals, respectively. The symbols * indicates a significant difference between experimental conditions (i.e. DAY versus NIGHT, BBoff versus BBon) within the same group with p<0.05.</p

RMSE at long time scales over HP and QT series.

<p>RMSE mean (plus standard deviation) assessed at long time scales (i.e. τ = 5–12) over HP series, RMSE_{HP,τ = 5–12} (a,c,e), and QT series, RMSE_{QT,τ = 5–12} (b,d,f), is shown as a function of the experimental protocol. RMSE_{HP,τ = 5–12} and RMSE_{QT,τ = 5–12} are depicted as a function of the group of subjects in the NMC-MC protocol in (a) and (b) respectively, as a function of the period of analysis in the DAY-NIGHT protocol in (c) and (d) respectively, and as a function of the therapy in the BBoff-BBon protocol in (e) and (f) respectively. The gray, dark and white bars are relevant to NMC, ASYMP and SYMP individuals, respectively. The symbol * indicates a significant difference between experimental conditions (i.e. DAY versus NIGHT, BBoff versus BBon) within the same group with p<0.05. The symbol ^# indicates a significant difference between groups within the same experimental conditions (i.e. DAY, NIGHT, BBoff or BBon) with p<0.05.</p

Time domain indexes derived from HP and QT series in the DAY-NIGHT protocol.

<p>μ_HP  =  HP mean; σ²_HP  =  HP variance; μ_QT  =  QT mean; σ²_QT  =  QT variance; DAY  =  daytime; NIGHT  =  nighttime; ASYMP  =  asymptomatic group; SYMP  =  symptomatic group. Results are reported as mean ± standard deviation. The symbol * indicates p<0.05 within the same group (i.e. ASYMP or SYMP) versus DAY. The symbol ^# indicates p<0.05 within the same period of analysis (i.e. DAY or NIGHT) versus ASYMP subjects.</p

Comparison between RMSE indexes derived from HP and QT series.

<p>RMSE mean (plus standard deviation) assessed at short time scale (i.e. τ = 1), RMSE_τ = 1 (a,d,g), at medium time scales (i.e. τ = 2–4), RMSE_{τ = 2–4} (b,e,h), and at long time scales (i.e. τ = 5–12), RMSE_{τ = 5–12}, (c,f,i) is shown as a function of the time series (i.e. HP and QT). RMSE_τ = 1, RMSE_{τ = 2–4}, and RMSE_{τ = 5–12} were obtained by pooling RMSE values computed BBoff during DAY (a,b,c), BBoff during NIGHT in (d,e,f), and BBon during DAY (g,h,i), The symbols § and ° indicate a significant difference with p<0.001 and p<0.05 respectively.</p

Time domain indexes derived from HP and QT series in the BBoff-BBon protocol.

<p>μ_HP  =  HP mean; σ²_HP  =  HP variance; μ_QT  =  QT mean; σ²_QT  =  QT variance; BBoff  =  off beta-blocker therapy; BBon  =  on beta-blocker therapy; ASYMP  =  asymptomatic group; SYMP  =  symptomatic group. Results are reported as mean ± standard deviation. The symbol ^* indicates p<0.05 within the same group (i.e. ASYMP or SYMP) versus BBoff. The symbol ^# indicates p<0.05 within the same therapy (i.e. BBoff or BBon) versus ASYMP subjects.</p

Time domain indexes derived from HP and QT series in the NMC-MC protocol.

<p>μ_HP  =  HP mean; σ²_HP  =  HP variance; μ_QT  =  QT mean; σ²_QT  =  QT variance; NMC  =  non mutation carrier group; ASYMP  =  asymptomatic group; SYMP  =  symptomatic group. Results are reported as mean ± standard deviation. The symbol ^§ indicates p<0.05 versus NMC individuals. The symbol ° indicates p<0.05 versus ASYMP subjects.</p

Overview plots for top <i>cis</i> eQTLs.

<p>An overview of the 4 most significant <i>cis</i> eQTLs: rs11150882 with <i>C17orf97</i> (panel A), rs11158569 with <i>CHURC1</i> (panel B), rs2779212 with <i>ZSWIM7</i> (panel C) and rs2549794 with <i>ERAP2</i> (panel D). On the left of each panel, box-and-whisker plots of mRNA levels for all genotypes. On the right, mean and standard-error plots of mRNA levels for all genotypes are illustrated. Right upper corner gives the association p-value and the gene name.</p

Look-up of SNPs from cardiac GWAS in eQTL data.

<p>Overview of eQTL effects of reported cardiac electric trait related GWAS SNPs. Only GWAS SNPs reaching genome-wide significance as stated in the original studies (p-value ≤5×10⁻⁸) and with nominal eQTL association (p≤0.05) are reported. This resulted in 34 independent loci. <i>PRKCA</i> (<i>rs9912468</i>, QRS duration) reaches genome-wide significance (4×10⁻⁸; represented in bold in table). The beta is defined as the effect size per copy of the minor allele. LD  =  linkage disequilibrium, TSS  =  transcription start site, Chr.  =  chromosome, Y  =  yes, N  =  no.</p

eQTL overview plots for 4 cardiac trait GWAS candidate genes.

<p>An overview of 4 GWAS <i>cis</i> eQTLs: rs9912468 with <i>PRKCA</i> (panel A), rs7912445 with <i>GNB4</i> (panel B), rs8049607 with <i>LITAF</i> (panel C) and rs6882776 with <i>NKX2-5</i> (panel D). On the left of each panel, box-and-whisker plots of mRNA levels for all genotypes. On the right, mean and standard-error plots of mRNA levels for all genotypes are illustrated. Right upper corner gives the association p-value and the gene name.</p

Overview of the 30 most significant <i>cis</i> eQTLs, reported as independent LD-pruned SNP clusters (see Materials & Methods).

<p>The MAF and beta (effect size per copy of the minor allele) for the most significant SNP of each cluster is listed. LD  =  linkage disequilibrium, TSS  =  transcription start site, Chr.  =  chromosome.</p