Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases

The number of Clostridium difficile infections (CDI) has significantly increased in Poland and throughout Europe. Their treatment involves the administration of metronidazole, vancomycin or fidaxomicin as indicated in current recommendations. Despite proper approach to the treatment, numerous recurrences of Clostridium difficile are reported. Fecal microflora transplant (FMT) is an alternative yet effective method of treatment of CDI. Moreover, this method is increasingly implemented in other disease entities.   DESCRIPTION OF THE PROBLEM: Fecal microflora transplant (FMT) is a safe method of treating intestinal dysbiosis. The therapy is based on transferring the stool suspension from a healthy human (donor) to the patient (recipient). The transplant can be performed by oral route (through the gastric/duodenal probe) or via the rectal route (colonoscopy). The donor of the FMT material must give an informed consent to have performed numerous blood and stool tests that are included in the donor selection procedures. The day before transplant, the recipient has to take the last dose of vancomycin taken in the 14-day treatment

Dengue virus infection in a course of typhoid fever

Dengue is a mosquito-borne viral infection caused by dengue virus (DENV) belonging to a group of Flaviviridae. Disease is widely spread in tropical and subtropical regions of Southeast Asia, Africa and the Americas. DENV infection causes a spectrum of illness including flu-like syndrome and potentially life-threatening dengue hemorrhagic fever. Confirmation of DENV infection requires serological serum tests or detection of viral genetic material in a serum sample. There no specific treatment for dengue but symptomatic therapy should be implemented in all cases. Recently there are two modern DENV vaccines available for the people living in the countries at a risk of infection. Efficiency and safety profile of both vaccines are debatable. Dengue symptoms may imitate clinical picture of other diseases that are typical for endemic DENV regions. We present a case of 22-year-old Indonesian woman treated originally due to typhoid fever who develop the symptoms of DENV infection

Fatal methanol poisoning due to massive windshield screen washer fluid ingestion - case report

Methanol is a toxic alcohol that can imitate ethanol in smell and taste. It has many household and industrial applications but can also be present in informally-produced alcoholic beverages. Methanol poisoning feature with high mortality and may be seen due to its intentional or unintentional ingestion. Metanol does not have significant intrinsic activity but its metabolites, especially format lead to severe metabolic acidosis, visual disturbances and neurological deficit. Diagnosis is mainly based upon the typical clinical course, metabolic acidosis with high osmolar gap and detection of methanol in plasma or urine. Recent guidelines recommend therapy using the competitive alcohol dehydrogenase inhibitors - fomepizol or ethanol. In cases of severe poisoning hemodialysis should be considered. We present a case of a 39-year-old male who was considered to Emergency Department due to consumed high amount of windshield washer fluid containing methanol. Intoxicated patient was unstable with respiratory insufficiency and consciousness impairment. Despite of implemented treatment - hemodialysis, ethanol infusion and active respiratory therapy - patient died on seventh day after admission to a hospital. Methanol poisonings feature with high mortality even when the best healthcare is provided. It depends mainly on a dose of ingested alcohol and delay in admission to a hospital

Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) during the course of lung cancer. A case report

Introduction. Hyponatremia is a frequently observed electrolyte disorder among patients with cancer. In 1957, Schwartz et al. reported the first case of a patient with hyponatremia due to SIADH, secondary to lung cancer. From that moment on, there has been data published that indicates patients with SIADH are less responsive to chemotherapy, have greater predisposition to central nervous system metastases and are often characterized by an advanced stage of cancer during time of diagnosis. Hyponatremia has many possible causes, and the differential diagnosis can pose a challenge. Aim. The aim of the study was to consider the occurrence of secondary hyponatremia in the course of cancer and the significance of this disorder in the prognosis of the disease. Methods. An analysis of the clinical history of the patient and a review of available literature. Results. A 66-year old patient with hyponatremia was admitted to the Department of Endocrinology, and lung cancer was determined as the cause of the aforementioned electrolyte disorder. Conclusion. SIADH secondary to cancers should be included in a differential diagnosis of every case of hyponatremia of undetermined etiology

Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) during the course of lung cancer. A case report

Introduction. Hyponatremia is a frequently observed electrolyte disorder among patients with cancer. In 1957, Schwartz et al. reported the first case of a patient with hyponatremia due to SIADH, secondary to lung cancer. From that moment on, there has been data published that indicates patients with SIADH are less responsive to chemotherapy, have greater predisposition to central nervous system metastases and are often characterized by an advanced stage of cancer during time of diagnosis. Hyponatremia has many possible causes, and the differential diagnosis can pose a challenge. Aim. The aim of the study was to consider the occurrence of secondary hyponatremia in the course of cancer and the significance of this disorder in the prognosis of the disease. Methods. An analysis of the clinical history of the patient and a review of available literature. Results. A 66-year old patient with hyponatremia was admitted to the Department of Endocrinology, and lung cancer was determined as the cause of the aforementioned electrolyte disorder. Conclusion. SIADH secondary to cancers should be included in a differential diagnosis of every case of hyponatremia of undetermined etiology

Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases

Krawiec Karol, Sławiński Aleksander, Ryczkowski Aleksander, Neścior Małgorzata, Toruń Zuzanna, Orzeł Anna, Majchrzak Aleksandra, Piech Piotr. Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases. Journal of Education, Health and Sport. 2018;8(9):926-932. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1418545 http://ojs.ukw.edu.pl/index.php/johs/article/view/5985 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.09.2018. Revised: 12.09.2018. Accepted: 12.09.2018. Possibilities of using intestinal microflora transplantation in the treatment of gastrointestinal diseases Karol Krawiec(1) , Aleksander Sławiński(1), Aleksander Ryczkowski(1), Małgorzata Neścior(1), Zuzanna Toruń(1), Anna Orzeł(1), Aleksandra Majchrzak(1), Piotr Piech (2) (1) Student’s Scientific Group at Department of Epidemiology and Clinical Research Methodology of Medical University of Lublin, Poland (2) Department of Human Anatomy, Medical University of Lublin, Poland Aleksander Sławiński: [email protected] Keywords: Clostridium difficile infections, Fecal microflora transplant, diarrhea ABSTRACT The number of Clostridium difficile infections (CDI) has significantly increased in Poland and throughout Europe. Their treatment involves the administration of metronidazole, vancomycin or fidaxomicin as indicated in current recommendations. Despite proper approach to the treatment, numerous recurrences of Clostridium difficile are reported. Fecal microflora transplant (FMT) is an alternative yet effective method of treatment of CDI. Moreover, this method is increasingly implemented in other disease entities. DESCRIPTION OF THE PROBLEM: Fecal microflora transplant (FMT) is a safe method of treating intestinal dysbiosis. The therapy is based on transferring the stool suspension from a healthy human (donor) to the patient (recipient). The transplant can be performed by oral route (through the gastric/duodenal probe) or via the rectal route (colonoscopy). The donor of the FMT material must give an informed consent to have performed numerous blood and stool tests that are included in the donor selection procedures. The day before transplant, the recipient has to take the last dose of vancomycin taken in the 14-day treatment

Is there any association between manganese level and schizophrenia? - a descriptive review

Introduction: Manganese has a role in the membrane transport systems, synthesis of protein, vitamin C, and vitamins B, catalysis of hematopoiesis, regulation of the endocrine, immune system, blood sugar, reproduction, digestion, and blood coagulation. Furthermore, the level of manganese concentrations in human body appears to affect the occurrence of schizophrenia. The aim of this study was to search for relationships between the manganese level and the onset of schizophrenia