5 research outputs found
Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literature
Spontaneous intracranial hypotension (SICH) is an entity, which is
secondary to iatrogenic manipulation and breaching of dura. Postural
headache in patients should be suspected, cranial magnetic resonance
imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is
regular shape of pachymeningeal gadolinium enhancement and subdural
effusion. It may mimic central nervous system (CNS) metastasis.
Prevention of such cases from receiving cranial radiotherapy by
misinterpretation of the gadolinium enhancement as CNS metastasis is an
important issue. Capecitabine is an antineoplastic agent, of which
metabolites can cross blood-brain barrier in CNS via epithelial tissue.
It may cause decrease in CSF production. SICH might be the clinical
reflection of this decrease in CSF production. Review of the English
literature revealed limited data because of the very little experience
with oncologic patients suffering from intracranial hypotension. We
report a case of spontaneous intracranial hypotension during
capecitabine treatment. Patient was completely well following drug
discontinuation and supportive treatment
Capecitabine-related intracranial hypotension syndrome mimicking dural metastasis in a breast cancer patient: Case report and review of the literature
Spontaneous intracranial hypotension (SICH) is an entity, which is
secondary to iatrogenic manipulation and breaching of dura. Postural
headache in patients should be suspected, cranial magnetic resonance
imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is
regular shape of pachymeningeal gadolinium enhancement and subdural
effusion. It may mimic central nervous system (CNS) metastasis.
Prevention of such cases from receiving cranial radiotherapy by
misinterpretation of the gadolinium enhancement as CNS metastasis is an
important issue. Capecitabine is an antineoplastic agent, of which
metabolites can cross blood-brain barrier in CNS via epithelial tissue.
It may cause decrease in CSF production. SICH might be the clinical
reflection of this decrease in CSF production. Review of the English
literature revealed limited data because of the very little experience
with oncologic patients suffering from intracranial hypotension. We
report a case of spontaneous intracranial hypotension during
capecitabine treatment. Patient was completely well following drug
discontinuation and supportive treatment