Method for performing cerebral perfusion-weighted MRI in neonates

Cerebral perfusion-weighted imaging (PWI) in neonates is known to be technically difficult and there are very few published studies on its use in preterm infants. In this paper, we describe one convenient method to perform PWI in neonates, a method only recently used in newborns. A device was used to manually inject gadolinium contrast material intravenously in an easy, quick and reproducible way. We studied 28 newborn infants, with various gestational ages and weights, including both normal infants and those suffering from different brain pathologies. A signal intensity-time curve was obtained for each infant, allowing us to build perfusion maps. This technique offered a fast and easy method to manually inject a bolus gadolinium contrast material, which is essential in performing PWI in neonates. Cerebral PWI is technically feasible and reproducible in neonates of various gestational age and with various pathologie

Prenatal diagnosis of congenital lung malformations

Prenatal diagnosis of congenital lung anomalies has increased in recent years as imaging methods have benefitted from technical improvements. The purpose of this pictorial essay is to illustrate typical imaging findings of a wide spectrum of congenital lung anomalies on prenatal US and MRI. Moreover, we propose an algorithm based on imaging findings to facilitate the differential diagnosis, and suggest a follow-up algorithm during pregnancy and in the immediate postnatal perio

CT radiation dose in children: a survey to establish age-based diagnostic reference levels in Switzerland

This work aimed at assessing the doses delivered in Switzerland to paediatric patients during computed tomography (CT) examinations of the brain, chest and abdomen, and at establishing diagnostic reference levels (DRLs) for various age groups. Forms were sent to the ten centres performing CT on children, addressing the demographics, the indication and the scanning parameters: number of series, kilovoltage, tube current, rotation time, reconstruction slice thickness and pitch, volume CT dose index (CTDIvol) and dose length product (DLP). Per age group, the proposed DRLs for brain, chest and abdomen are, respectively, in terms of CTDIvol: 20, 30, 40, 60mGy; 5, 8, 10, 12mGy; 7, 9, 13, 16mGy; and in terms of DLP: 270, 420, 560, 1,000mGy cm; 110, 200, 220, 460mGy cm; 130, 300, 380, 500mGy cm. An optimisation process should be initiated to reduce the spread in dose recorded in this study. A major element of this process should be the use of DRL

MR and CT imaging of pulmonary valved conduits in children and adolescents: normal appearance and complications

Background: The Contegra® is a conduit made from the bovine jugular vein and then interposed between the right ventricle and the pulmonary artery. It is used for cardiac malformations in the reconstruction of right ventricular outflow tract. Objective: To describe both normal and pathological appearances of the Contegra® in radiological imaging, to describe imaging of complications and to define the role of CT and MRI in postoperative follow-up. Materials and methods: Forty-three examinations of 24 patients (17 boys and 7 girls; mean age: 10.8years old) with Contegra® conduits were reviewed. Anatomical description and measurements of the conduits were performed. Pathological items examined included stenosis, dilatation, plicature or twist, thrombus or vegetations, calcifications and valvular regurgitation. Findings were correlated to the echographic gradient through the conduit when available. Results: CT and MR work-up showed Contegra® stenosis (n = 12), dilatation (n = 9) and plicature or twist (n = 7). CT displayed thrombus or vegetations in the Contegra® in three clinically infected patients. Calcifications of the conduit were present at CT in 12 patients and valvular regurgitation in three patients. The comparison between CT and/or MR results showed a good correlation between the echographic gradient and the presence of stenosis in the Contegra®. Conclusion: CT and MR bring additional information about permeability and postoperative anatomy especially when echocardiography is inconclusive. Both techniques depict the normal appearance of the conduit, and allow comparison and precise evaluation of changes in the postoperative follow-up

Relic galaxy analogues in TNG50 simulation : the formation pathways of surviving red nuggets in a cosmological simulation

Relic galaxies are massive compact quiescent galaxies that formed at high-redshift and remained almost unchanged since then. In this work, we search for analogues to relic galaxies in the TNG50 cosmological simulations to understand relic formation and test the ability of TNG50 to reproduce such rare objects. Using stellar mass, age, radius, quiescence, and stellar assembly criteria, we find five subhaloes in TNG50 that could be potential relic analogues. We compare their properties with other constraints imposed by a sample of 13 observed relic galaxies. We find one analogue in TNG50 that simultaneously satisfies most of the available observational constraints, such as metallicity and morphology. It also shows similarities to the confirmed relic NGC 1277, regarding environment and dark matter fraction. By taking into account a degree of relicness, a second relic analogue may also be considered. However, the central parts of the brightness and density profiles of the analogues are less steep than that of real relic galaxies, possibly due to limited numerical resolution. We identify two formation pathways of relic analogues in TNG50 depending on their environment: they either have their remaining gas stripped during the infall into a cluster at z 1.2 or consume it before z > 1.5. They are then deprived of significant star formation, leaving their stellar populations almost unaltered during the last 9 Gyr. We also find that the analogue progenitors at z ∼ 4 inhabit more massive haloes than progenitors of quiescent galaxies with similar stellar mass at z ∼ 0

Globular cluster systems of relic galaxies

We analyse the globular cluster (GC) systems of a sample of 15 massive, compact early-type galaxies (ETGs), 13 of which have already been identified as good relic galaxy candidates on the basis of their compact morphologies, old stellar populations and stellar kinematics. These relic galaxy candidates are likely the nearby counterparts of high-redshift red nugget galaxies. Using F814W (≈I) and F160W (≈H) data from the WFC3 camara onboard the Hubble Space Telescope, we determine the total number, luminosity function, specific frequency, colour, and spatial distribution of the GC systems (GCSs). We find lower specific frequencies (SN < 2.5 with a median of SN = 1) than ETGs of comparable mass. This is consistent with a scenario of rapid, early dissipative formation, with relatively low levels of accretion of low-mass, high-SN satellites. The GC half-number radii are compact, but follow the relations found in normal ETGs. We identify an anticorrelation between the specific angular momentum (λR) of the host galaxy and the (I − H) colour distribution width of their GCSs. Assuming that λR provides a measure of the degree of dissipation in massive ETGs, we suggest that the (I − H) colour distribution width can be used as a proxy for the degree of complexity of the accretion histories in these systems

The puzzling origin of massive compact galaxies in MaNGA

We characterized the kinematics, morphology, and stellar population (SP) properties of a sample of massive compact quiescent galaxies (MCGs, 10 log M /M 11 and re ∼ 1–3 kpc) in the MaNGA Survey, with the goal of constraining their formation, assembly history, and assessing their relation with non-compact quiescent galaxies. We compared their properties with those of a control sample of median-sized quiescent galaxies (re ∼ 4–8 kpc) with similar effective velocity dispersions. MCGs have elevated rotational support, as evidenced by a strong anticorrelation between the Gauss–Hermite moment h3 and V/σ. In contrast, 30 per cent of control sample galaxies (CSGs) are slow rotators, and fast-rotating CSGs generally show a weak h3–V/σ anticorrelation. MCGs and CSGs have similar ages, but MCGs are more metal-rich and α-enhanced. Both MCGs and CSGs have shallow negative metallicity gradients and flat [α/Fe] gradients. On average, MCGs and CSGs have flat age gradients, but CSGs have a significantly larger dispersion of gradient values. The kinematics and SP properties of MCGs suggest that they experienced highly dissipative gas-rich events, such as mergers, followed by an intense, short, and centrally concentrated burst of star formation, between 4 and 10 Gyr ago (z ∼ 0.4–2), and had a quiet accretion history since then. This sequence of events might be analogous to, although less extreme than, the compaction events that formed compact quiescent galaxies at z ∼ 2. The small sizes of MCGs, and the high efficiency and short duration of their last star formation episode suggest that they are descendants of compact post-starburst galaxies

Diagnóstico preoperatorio de la coledocolitiasis en la era de la colecistectomía laparoscópica : utilidad y estudio comparativo de parámetros analíticos, ecografía y colangiotomografía intravenosa / Leonor Alamo Maestre ; directores Pascual Parrilla Paricio, Juan Antonio Luján Mompeán.

Tesis-Universidad de Murcia.MEDICINA ESPINARDO. DEPOSITO. MU-Tesis 464.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M.-1355

Imaging findings in fetal diaphragmatic abnormalities

Imaging plays a key role in the detection of a diaphragmatic pathology in utero. US is the screening method, but MRI is increasingly performed. Congenital diaphragmatic hernia is by far the most often diagnosed diaphragmatic pathology, but unilateral or bilateral eventration or paralysis can also be identified. Extralobar pulmonary sequestration can be located in the diaphragm and, exceptionally, diaphragmatic tumors or secondary infiltration of the diaphragm from tumors originating from an adjacent organ have been observed in utero. Congenital abnormalities of the diaphragm impair normal lung development. Prenatal imaging provides a detailed anatomical evaluation of the fetus and allows volumetric lung measurements. The comparison of these data with those from normal fetuses at the same gestational age provides information about the severity of pulmonary hypoplasia and improves predictions about the fetus's outcome. This information can help doctors and families to make decisions about management during pregnancy and after birth. We describe a wide spectrum of congenital pathologies of the diaphragm and analyze their embryological basis. Moreover, we describe their prenatal imaging findings with emphasis on MR studies, discuss their differential diagnosis and evaluate the limits of imaging methods in predicting postnatal outcome