Towards a Business Process Complexity Analysis Framework Based on Textual Data and Event Logs

Being an established discipline, Business Process Management (BPM) confronts various challenges related to digitization and rapid penetration of technologies into business processes (BPs). As a result, both generated and used data, such as textual data and event logs, grow exponentially, complicating the decision-making. Event logs are typically used to analyze BPs from several perspectives, including complexity. Recent approaches to BP complexity analyses focus on BP models and event logs, limiting the consideration of textual data. Hence, we propose a BP complexity analysis framework combining textual data and event logs. The framework has been conceptualized based on the IT Service Management (ITSM) case study of an international telecom provider and further developed in the IT department of an academic institution. The latter has also been used to investigate the value of the framework. Our preliminary findings show that the framework can enable comprehensive process redesign and improvements

Learning Languages without Grammar

This article presents how natural approach is effective in teaching or learning language using this Natural Approach learners will be able to elicit the language like small children are learning their mother tongue in their family. Many language teachers of English, Turkish and Arabic insist on the structure of the language, they claimed that it should be firstly taught the grammar then the learner will be able to learn and use it. This paper examines Stephen Krashen, and Tracy David Terrell’s The Natural Approach .Whereas well-given examples of Communicative Approach that, was developed by Robert Langs MD, in the early 1970's.The results show that learners should get input in the current language. By using and practicing the input, language learners will get improvement. The work presented here was profound implications for future studies of language learning and may help solve the problem of practicing foreign language. DOI: 10.5901/jesr.2014.v4n2p3

Clopidogrel responsiveness in chronic kidney disease patients with acute coronary syndrome

Objective: Cardiovascular diseases are the leading cause of death in patients with chronic kidney disease (CKD). There is conflicting evidence about effect of CKD on clopidogrel responsiveness. We aimed to evaluate the clopidogrel responsiveness in CKD patients with acute coronary syndrome (ACS). Methods: A total of 101 patients; 55 with moderate to severe CKD and 46 with normal renal function or mild CKD, hospitalized with ACS were included in our study. Multiplate test was used to determine clopidogrel responsiveness. Platelet aggregation results were presented as aggregation unit (AU)*min and values over 470 AU*min were accepted as clopidogrel low responders. Results: The 101 patients (mean age 64.76±8.67 years; 61 [60.4%] male) were grouped into the two study groups as follows: group 1; 55 patients with eGFR<60 ml/min/1.73 m2 and group 2; 46 patients with eGFR>60 ml/min/1.73 m2. 35 patients (34.7%) of the study population were found to have low response to clopidogrel (16 [34.8%] patients in group 1 and 18 [33.3%] patients in group 2, p=0.879) . There was no significant difference between group 1 and 2 for Multiplate test results (414.67±281.21 vs 421.56±316.19 AU*min, p=0.909). Clopidogrel low responsiveness were independently related to Multiplate test results of aspirin responsiveness (OR=1.004, CI 1.002–1.007, p=0.001) and hemoglobin (OR=0.727, CI 0.571–0.925, p=0.010). Multiplate results were also independently related to Multiplate test results of aspirin responsiveness (β=0.402, p<0.0001) and hemoglobin (β=-0.251, p=0.007). Conclusion: Platelet response to clopidogrel does not differ between patients with eGFR < 60 ml/min/1.73 m2 and eGFR>60 ml/min/1.73 m2

In Vitro Cytotoxic Effects of Some Covid-19 Drugs on Lung Cancer Cells

DergiPark: 901480trkjnatCancer, which is the second most common cause of death after cardiovascular diseases, is one of the most important health problems of today. Discovery of effective treatments and drugs are important in cancer treatment. The COVID-19 epidemic, which broke out in Wuhan province of China in December 2019 and is considered as a pandemic worldwide, affected millions of people. The SARS-CoV-2 virus, which causes this epidemic, affects the lungs, heart, brain, kidneys, gastrointestinal system, ovaries and testicles and various drugs are used in the treatment. In this study, we aimed to determine the cytotoxic effect of favipiravir, dornase alfa and ivermectin, which are drugs used in the treatment of COVID-19, on human lung cancer cell line (A549). Favipiravir, dornase alfa and ivermectin concentrations were prepared in doubly increasing doses (0.5-64 µg/mL). The prepared concentrations were tested on human A549 cells. After 24 hours of incubation, the cytotoxic effects of the drugs on cancer cells were detected by the MTT (3-(4,5-dimethylthiazol-2-yl)-diphenyl tetrazolium bromide) method. The results were given as % viability. It was determined that favipiravir, dornase alfa and ivermectin significantly decreased the cell viability in lung cancer cell line with increasing application doses (p lt;0.05). Kalp damar hastalıklarından sonra ikinci ölüm nedeni olan kanser, günümüzün en önemli sağlık sorunlarından biridir. Etkili tedavilerin ve yeni ilaçların keşfedilmesi kanser tedavisinde önem arz etmektedir. Aralık 2019'da Çin'in Wuhan eyaletinde patlak veren ve dünya çapında bir salgın olarak kabul edilen COVID-19 salgını milyonlarca insanı etkilemektedir. Bu salgına neden olan SARS-CoV-2 virüsü başta akciğerleri olmak üzere kalbi, beyni, böbrekleri, gastrointestinal sistemi, yumurtalık ve testisleri etkilemekte ve tedavisinde çeşitli ilaçlar kullanılmaktadır. Bu çalışmada, COVID-19 tedavisinde kullanılan ilaçlar olan favipiravir, dornaz alfa ve ivermektinin insan akciğer kanseri hücre hattı (A549) üzerindeki sitotoksik etkisinin belirlenmesi amaçlanmıştır. Çalışmada favipiravir, dornaz alfa ve ivermektin ilaçlarının konsantrasyonları iki kat artan dozlarda (0,5-64 µg/mL) hazırlandı. Hazırlanan konsantrasyonlar, insan A549 hücreleri üzerine uygulandı. 24 saatlik inkübasyondan sonra, ilaçların hücre hatları üzerindeki sitotoksik etkileri, MTT (3-(4,5-dimetiltiyazol-2-il)-difenil tetrazolyum bromür) yöntemi ile tespit edildi. Sonuçlar % canlılık olarak verildi. Artan doza bağlı olarak favipiravir, dornaz alfa ve ivermektinin akciğer kanseri hücre dizisinde hücre canlılığını önemli ölçüde azalttığı belirlendi (p lt;0.05)

Cambrian-Eocene pre-rift, pulsed rift, passive margin and emplacement processes along the northern margin of the Southern Neotethys: evidence from the Antalya Complex in the Alanya Window (S Turkey)

Sedimentary rocks in the Alanya Window document pulsed Permian-Triassic rifting in a proximal basin setting, adjacent to the Tauride continental unit (Geyik Dağ). Late Cambrian-Early Ordovician clastic sediments accumulated along the north margin of Gondwana on a variable shallow-marine shelf. Above an unconformity related to rift-shoulder uplift, Late Permian facies document shallow-marine to evaporitic environments during regional tectonic subsidence (first main rift pulse). Above a second unconformity (both extension and sea-level controlled), Early Triassic carbonates and mudrocks accumulated on an unstable, gently subsiding shelf. Mudrocks, sandstones and lithoclastic debris-flows, derived from the underlying succession, accumulated during the Middle Triassic (Anisian-early Ladinian), implying strong tectonic subsidence and flank uplift (second main rift pulse). Radiolarian mudstones accumulated during late Middle Triassic-early Late Triassic in a well-oxidised, organically productive, but relatively quiescent, deep-water basin above the carbonate compensation depth (CCD). Thick (100s m) lithoclastic sandstone turbidites (commonly plant-rich) and localised debris-flows accumulated during the Late Triassic (Carnian), together with detached blocks of underlying lithologies (third main rift pulse, with regional uplift). Alkaline basaltic sills were intruded locally. Final continental break-up to create the Southern Neotethys took place regionally during the Late Triassic (Carnian). Latest Triassic-Late Cretaceous deposition records passive margin subsidence. Variable low-grade metamorphism and two-stage tectonic emplacement (southwards(?) then northwards) took place during latest Cretaceous and Eocene, respectively. The tectonic-sedimentary development of the Antalya Complex provides insights into rift/continental break-up processes that differ from the recently well-documented Alpine-North Atlantic region.Publisher PDFPeer reviewe

Congenital Diarrhea and Cholestatic Liver Disease: Phenotypic Spectrum Associated with MYO5B Mutations

Myosin Vb (MYO5B) is a motor protein that facilitates protein trafficking and recycling in polarized cells by RAB11- and RAB8-dependent mechanisms. Biallelic MYO5B mutations are identified in the majority of patients with microvillus inclusion disease (MVID). MVID is an intractable diarrhea of infantile onset with characteristic histopathologic findings that requires life-long parenteral nutrition or intestinal transplantation. A large number of such patients eventually develop cholestatic liver disease. Bi-allelic MYO5B mutations are also identified in a subset of patients with predominant early-onset cholestatic liver disease. We present here the compilation of 114 patients with disease-causing MYO5B genotypes, including 44 novel patients as well as 35 novel MYO5B mutations, and an analysis of MYO5B mutations with regard to functional consequences. Our data support the concept that (1) a complete lack of MYO5B protein or early MYO5B truncation causes predominant intestinal disease (MYO5B-MVID), (2) the expression of full-length mutant MYO5B proteins with residual function causes predominant cholestatic liver disease (MYO5B-PFIC), and (3) the expression of mutant MYO5B proteins without residual function causes both intestinal and hepatic disease (MYO5B-MIXED). Genotype-phenotype data are deposited in the existing open MYO5B database in order to improve disease diagnosis, prognosis, and genetic counseling.This research was funded by Jubiläumsfonds der Österreichischen Nationalbank, grant no.16678 (to A.R.J.), grant no. 18019 (to G.-F.V.) and Tiroler Wissenschaftsfonds, grant No. 0404/2386 (toG.-F.V.).info:eu-repo/semantics/publishedVersio

Congenital Diarrhea and Cholestatic Liver Disease: Phenotypic Spectrum Associated with MYO5B Mutations.

Myosin Vb (MYO5B) is a motor protein that facilitates protein trafficking and recycling in polarized cells by RAB11- and RAB8-dependent mechanisms. Biallelic MYO5B mutations are identified in the majority of patients with microvillus inclusion disease (MVID). MVID is an intractable diarrhea of infantile onset with characteristic histopathologic findings that requires life-long parenteral nutrition or intestinal transplantation. A large number of such patients eventually develop cholestatic liver disease. Bi-allelic MYO5B mutations are also identified in a subset of patients with predominant early-onset cholestatic liver disease. We present here the compilation of 114 patients with disease-causing MYO5B genotypes, including 44 novel patients as well as 35 novel MYO5B mutations, and an analysis of MYO5B mutations with regard to functional consequences. Our data support the concept that (1) a complete lack of MYO5B protein or early MYO5B truncation causes predominant intestinal disease (MYO5B-MVID), (2) the expression of full-length mutant MYO5B proteins with residual function causes predominant cholestatic liver disease (MYO5B-PFIC), and (3) the expression of mutant MYO5B proteins without residual function causes both intestinal and hepatic disease (MYO5B-MIXED). Genotype-phenotype data are deposited in the existing open MYO5B database in order to improve disease diagnosis, prognosis, and genetic counseling

A Cross-Organizational Process Mining Framework

Groups of people collaborate within organizations to deliver value to their customers. To establish such collaborations, which can lead to valuable outcomes for customers, a set of coordinated activities, events, and decision points are orchestrated in business processes. However, due to the diverse contexts of organizations, the meaning of terms used in business processes often differ from one organization to another. Moreover, the way a business process is executed may differ across organizations, in some branches of the same organization, or for certain products or services offered to customers, or even across organizational units. Those differences, furthermore, affect both the performance of business processes and the relevance of performance indicators used for measuring that performance. Therefore, when such points are not taken into account, efforts to enable organizations to learn from each other for performance improvement can lead to three main issues, namely unfairness, inaccuracy, and inadequacy. The aforementioned issues inspire the work in this thesis. In particular, the thesis focuses on providing relevant insights for organizations to improve their performance by learning from each other. With the theoretical Cross-Organizational Process Mining Framework that we developed, that learning becomes possible for organizations. The main contributions of this thesis are five approaches. The approach for automatically deriving Key Performance Indicators (KPIs) from Ontological Enterprise Models deals with the unfairness issue. Inaccuracy is the main focus of the approach for predicting relevant KPIs for organizations. Identifying the perspectives that can be adequate for organizations to learn from each other is the main focus of the two other approaches: the approach for the automated generation of engaging dashboards and the approach for interactive process performance dashboard generation. The last approach is devoted to building process benchmarks for performance improvement such that organizations can benefit from each others' best practices. Each approach is applied in a real-life setting to show its usefulness and practical value. Overall, the work presented in this thesis provides important contributions to perform cross-organizational process mining in a fair, accurate, and adequate fashion