Clinical Experience with Adjunctive Lacosamide in Adult Patients with Focal Seizures

Objectives: The aim of this study was to report first clinical experience in Turkey using lacosamide (LCM) as adjunctive therapy in patients with focal onset seizure

The Relationship Between Carotid Intima-media Thickness and Homosystein in Ischemic Stroke

Objective: The vast majority of ischemic strokes occur due to atherosclerosis. Although the precise mechanism is unknown, high homocysteine (HM) levels are considered to play a role in the development of atherosclerosis. In this study, the relationship between high HM and carotid intima-media thickness (CIMT), as an early predictor of atherosclerosis, is evaluated in patients with ischemic stroke

Epilepsy due to Intracranial Surgery: 15 Years of Experience

Objectives: Epidemiological studies have shown increased incidence of epilepsy in cases of brain trauma, central nervous system infection, cerebrovascular disease (CVD), and brain tumors. Etiology of epilepsy varies according to age. In the etiology of partial and secondarily generalized partial seizures in adult patients, CVD is the most common cause of acute, symptomatic seizures. Frequency of seizures is estimated to be 15%-20% after cranial operations. In this study, characteristics of patients undergoing cranial surgery were investigated retrospectively

Effects of Lacosamide in Cerebral Tuberculoma-Induced Nonconvulsive Status Epilepticus: Case Report

Nonconvulsive status epilepticus (NCSE) is characterized by unexplained changes in behavior and mental status accompanied with continuous seizure activity seen on electroencephalography (EEG). Treatment is similar to treatment of status epilepticus. Lacosamide is one of the newer antiepileptic drugs (AEDs) that slow inactivation of voltage-dependent sodium channels. It has high oral bioavailability, is low protein binding and is primarily metabolized by the liver enzyme CYP2C19. Central nervous system (CNS) tuberculosis may present with signs of parenchymal lesions instead of meningitis. Presently described is a patient who was diagnosed as CNS tuberculosis a year ago with nonconvulsive status epilepticus. Status could be not be controlled with levetiracetam; however, use of lacosamide successfully resolved nonconvulsive status epilepticus

Evaluation of Autonomic Function in Patients with Obstructive Sleep Apnea Syndrome

Objective: Obstructive Sleep Apnea syndrome (OSAS) is a condition in which ever-repeating obstruction of upper airway during the sleep. In the present study, we aimed to evaluate the autonomic nervous system function in patients with moderate to severe OSAS. Materials an