11 research outputs found
Effects of Perturbation Training on Balance, Walking, and Lumbar Stabilization in Patients with Multiple Sclerosis: A Pilot Study
Objective: To investigate the effect of perturbation training (PT) on balance, walking, and lumbar stabilization in patients with multiple sclerosis.
Methods: Ten patients were given manual PT twice a week for 6 weeks. Romberg (RT), Sharpened Romberg (SR), and single leg stance test (SLST) were performed for static balance. Dynamic balance was assessed with functional reach test (FRT), lateral reach test [dominant (LRT-D) and non-dominant (LFR-ND)], and four square step test (FSST). The Falls Efficacy Scale International (FES-I) was used to evaluate the fear of falling. Timed up and go (TUG) test and pressure biofeedback stabilization were used to assess the functional mobility and lumbar stabilization.
Results: The results of SR and SLST were significantly increased after the treatment (p0.05). Significant differences were found in the values of FRT and LRT-ND. The results of LRT-D and FSST were not changed with the treatment. The fear of falling decreased after the treatment but was not statistically significant (p>0.05). After the treatment, the TUG duration improved in participants (p=0.01). No difference was found in the PBS duration between the pre and post-treatment (p>0.05).
Conclusion: This study revealed that manual PT without computerized systems in the clinic may improve static and dynamic balance, walking, and fear of falling. Additionally, the effect of PT on lumbar stabilization in MS was not determined in our study. Major conclusions were limited by the small sample size; however, the observed results may contribute to designing future trials
Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study
Background and Objectives: This study is designed to understand the
pathophysiology of one of the most serious health problems, chronic
tension-type headache (CTTH). Two polymorphic sites in serotonin
transporter protein gene attracted much interest. These are: the
variable number of tandem repeats (VNTR) and 5′-flanking promoter
region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR
polymorphisms were investigated in 126 CTTH patients and 138 healthy
control subjects. The patients were being treated with amitripytyline
or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR)
method was used to investigate the polymorphisms in the serotonin
transporter protein gene. Results: There were no statistically
significant results based on the 5-HTTLPR gene alleles, however, STin
2.12/12 genotype and STin 2.12 allele were seen to predominate the
control group. In order to investigate the combined effect of the two
polymorphic loci on the 5-HTT gene expression, samples were separated
into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed
statistically significant frequency in the CTTH group than in the
control group. No significant differences were noticed between the
5-HTTLPR and VNTR haplotype groups and success in treatment.
Conclusion: It is possible to make reliable comparisons and hypothesis
about the homozygous and/or heterozygous presence of S and STin 12/10
alleles which may be in interaction with CTTH. On the other hand, the
presence of homozygous L and STin12 alleles may play a protective role
against CTTH. It is also possible that heterogeneity among diseases
showing the same clinical research will require a lot of effort for
individual identification
The COVID-19 from Neurological Overview
Elmali, Ayse Deniz/0000-0001-6380-9550; Afsar, Nazire/0000-0001-8123-8560; Sahin, Sevki/0000-0003-2016-9965;WOS: 000556540500002[No abstract available
Investigation of the Rho-kinase 2 gene Thr431Asn polymorphism in migraine
Background: Migraine has a complex etiology determined by genetic and environmental factors, but the molecular mechanisms and genetics of this disease have not yet been fully clarified. Aim: This case/control study was designed to analyze the genotype distributions and allele frequencies for the Rho-kinase 2 (ROCK2) gene Thr431Asn polymorphism among the migraine patients. Materials and Methods: A total of 155 migraine patients and 155 healthy age and sex matched controls were included in this study. Genomic deoxyribonucleic acid from migraine patients and controls was analyzed by real-time polymerase chain reaction. Results: Neither genotype distributions nor the allele frequencies for the Thr431Asn polymorphism showed a significant difference between the groups. In addition, there were no marked differences in genotype and allele frequencies for the migraine without aura and migraine with aura subgroups when compared with control group. Conclusion: This is the first study to show that the ROCK2 gene Thr431Asn polymorphism is not a risk factor for the migraine in the Turkish population