Pre-Service Mathematics Teacher’s Argumentation Skills

The study was conducted with pre-service Math teachers in a teacher preparation programs to explore their argumentation skills. Data were collected via a problem to express their argumentative skills with various types of approaches. Finally, they evaluated problem for its appropriateness.</p

Optimization of electricity and hydrogen production with hybrid renewable energy systems

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GIS-based optimal site selection for the solar-powered hydrogen fuel charge stations

Energy consumption which is the most critical input in daily life is increasing constantly because of the growth of the world population and development of the devices. The transportation industry which is responsible for almost half of all worldwide emissions is switching to innovative devices run on renewable energy. Renewable-powered charging stations are important for reducing the environmental impact of vehicles. The objective of the study was to determine the best hydrogen charge station locations and rates which are supplied by coupled solar power plants. The GIS-based assessment was carried out with proper data from data sources such as Copernicus Land Monitoring (CLC 2018), and Global Solar Atlas (GSA). For the determination of suitable regions for solar power plants, eight sub-criteria were assessed under technical (C1), accessibility (C2), and environmental (C3) main criteria. Afterward, the obtained result map layer and suitability of the six determined water bodies, located in the study region, were investigated by assuming the buffer zone value. Results showed that the study area had suitable regions of 38.1&nbsp;km2&nbsp;indicating that %22.4 of it was convenient for the solar power plant investments. While Cihanbeyli Lake does not have the highest suitable region, the biggest suitable area inside the buffer zone of lakes was determined as the Ağcaşayar Dam. The maximum annual solar production level is obtained as 1,919 MWh/year in the Ağcaşayar Dam, with a hydrogen production of 34,933 tons/year. Consequently, the Ağcaşayar Dam is the best suitable destination for a hydrogen fuel station in Kayseri.</p

Long-Term Follow-Up Outcomes of 19 Patients with Osteogenesis Imperfecta Type XI and Bruck Syndrome Type I Caused by FKBP10 Variants

Osteogenesis imperfecta type XI (OI-XI) and Bruck syndrome type I (BS1) are two rare disorders caused by biallelic variants in the FKBP10, characterized by early-onset bone fractures and progressive skeletal deformities. The patients with OI-XI, also co-segregated with autosomal-recessive epidermolysis bullosa simplex caused by KRT14 variant, have been reported. In this study, the follow-up clinical features of the patients with OI-XI and BS1 phenotypes due to biallelic FKBP10 variants are compared. The aim of this study is to investigate the follow-up findings of OI-XI and BS1 phenotypes in patients with the FKBP10 variants. A total of 19 children, ten males and nine females, from 16 unrelated families were included in the study. FKBP10 variants were investigated by next-generation sequencing (NGS) based panel gene test or Sanger sequencing. Seventeen patients were followed between 1.5 and 16.8 years, and the last follow-up age was between 2 and 24.6 years (median 10.7 years). They received intravenous bisphosphonate infusions once every 3 months in follow-up period. We identified four different biallelic FKBP10 variants, two of which are novel (c.890_897dup TGATGGAC, p.Gly300Ter and c.1256 + 1G > A) in 16 families. Five of these patients also had findings of epidermolysis bullosa simplex, and the same biallelic c.612T > A (p.Tyr204Ter) variant in KRT14, as well as FKBP10, were identified. Twelve patients were diagnosed with OI-XI; whereas, seven were diagnosed with BS1. The BS1 phenotype was late-onset and the annual fracture number was lower. After bisphosphonate treatment, bone mineral densitometry Z score at L1-L4 increased (p = 0.005) and the number of annual fractures decreased (p = 0.036) in patients with OI-XI. However, no significant effect of bisphosphonate treatment was found on these values in BS1 patients. Despite the treatment, the rate of scoliosis and long bone deformity had increased in both groups at the last examination; and, only two patients could take a few steps with the aid of a walker, while others were not ambulatory, and they used wheelchairs for mobility. We identified two novel variants in FKBP10. Families originating from the same geographic region and having the same variant suggest founder effects. Although the number of fractures decreased with bisphosphonate treatment, none of our patients were able to walk during the follow-up. This study is valuable in terms of showing the follow-up findings of patients with FKBP10 variants for the first time