Lithographically fabricated optical cavities for refractive index sensing

Since the development of distributed Bragg gratings, high resolution lithography and etching have been applied towards the concentration of light. The most important application of lithographically fabricated microcavities has been for the spectral control over laser emission. Here we describe the opportunities that arise from further miniaturization of laser cavities by using high index contrast photonic crystal mirrors and annular Bragg reflectors. We have used these optical cavities, with mode volumes as small as 10^–17 l, to perform spectroscopic analysis and compare the mode volumes and sensitivities of these geometries

The memory space: Exploring future uses of Web 2.0 and mobile internet through design interventions.

The QuVis Quantum Mechanics Visualization project aims to address challenges of quantum mechanics instruction through the development of interactive simulations for the learning and teaching of quantum mechanics. In this article, we describe evaluation of simulations focusing on two-level systems developed as part of the Institute of Physics Quantum Physics resources. Simulations are research-based and have been iteratively refined using student feedback in individual observation sessions and in-class trials. We give evidence that these simulations are helping students learn quantum mechanics concepts at both the introductory and advanced undergraduate level, and that students perceive simulations to be beneficial to their learning.Comment: 15 pages, 5 figures, 1 table; accepted for publication in the American Journal of Physic

Large deviations and gradient flows

In recent work [1] we uncovered intriguing connections between Otto's characterisation of diffusion as entropic gradient flow [16] on one hand and large-deviation principles describing the microscopic picture (Brownian motion) on the other. In this paper, we sketch this connection, show how it generalises to a wider class of systems, and comment on consequences and implications. Specifically, we connect macroscopic gradient flows with large deviation principles, and point out the potential of a bigger picture emerging: we indicate that in some non- equilibrium situations, entropies and thermodynamic free energies can be derived via large deviation principles. The approach advocated here is different from the established hydrodynamic limit passage but extends a link that is well known in the equilibrium situation

Indoor environment quality and occupant productivity in the CH2 building

This paper presents a summary of the results from a post-occupancy evaluation study on indoor environment quality (lEO) and occupant health, wellbeing and productivity in the Council House 2 (CH2) building, which is owned and occupied by the City of Melbourne. This case study has highlighted that the productivity of office building occupants can potentially be enhanced through good building design, and provision of a high quality, healthy, comfortable and functional interior environment, that takes account of basic occupant needs.<br /

A gene regulatory network armature for T lymphocyte specification

Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process, we have used high-resolution analysis of regulatory gene expression trajectories from the beginning to the end of specification, tests of the short-term Notch dependence of these gene expression changes, and analyses of the effects of overexpression of two essential transcription factors, namely PU.1 and GATA-3. Quantitative expression measurements of >50 transcription factor and marker genes have been used to derive the principal components of regulatory change through which T cell precursors progress from primitive multipotency to T lineage commitment. Our analyses reveal separate contributions of Notch signaling, GATA-3 activity, and down-regulation of PU.1. Using BioTapestry (www.BioTapestry.org), the results have been assembled into a draft gene regulatory network for the specification of T cell precursors and the choice of T as opposed to myeloid/dendritic or mast-cell fates. This network also accommodates effects of E proteins and mutual repression circuits of Gfi1 against Egr-2 and of TCF-1 against PU.1 as proposed elsewhere, but requires additional functions that remain unidentified. Distinctive features of this network structure include the intense dose dependence of GATA-3 effects, the gene-specific modulation of PU.1 activity based on Notch activity, the lack of direct opposition between PU.1 and GATA-3, and the need for a distinct, late-acting repressive function or functions to extinguish stem and progenitor-derived regulatory gene expression

TSGL A Thread Safe Graphics Library for Visualizing Parallelism

AbstractMulticore processors are now the standard CPU architecture, and multithreaded parallel programs are needed to take full advantage of such CPUs. New tools are needed to help students learn how to design and build such parallel programs. In this paper, we present the thread-safe graphics library (TSGL), a new C++11 library that allows different threads to draw to a shared Canvas, which is updated in approximate real-time. Using TSGL, instructors and students can create visualizations that illustrate multithreaded behavior. We present three multithreaded applications that illustrate the use of TSGL to help students see and understand how an application is using parallelism to speed up its computation

Fundamental approach for optoelectronic and microfluidic integration for miniaturizing spectroscopic devices

We have described an approach for miniaturizing spectroscopic devices by using the advantages presented by elastomeric based microfluidics and semiconductor detectors/emitters. Elastomers allow for both absorption and fluorescent spectroscopy in the visible range to be conducted on small volumes of solution and allow for easy integration with existing detectors such as CMOS imagers, CCD imagers, and silicon photodiodes. Results of some basic experiments are presented to demonstrate the effectiveness of the system. In addition, several ideas for emission sources are also discussed with their relevance yet to be determined