7 research outputs found
Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited.
Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. Eligible patients were ≥ 20 years old, had bone metastases secondary to breast, lung or prostate cancer, or bone lesions associated with multiple myeloma, and had received radiation to bone between 1 July 2004 and 1 July 2009. HRU data were extracted from hospital patient charts from 3.5 months before the index SRE (radiation to bone preceded by a SRE-free period of ≥ 6.5 months) until 3 months after the last SRE that the patient experienced during the study period.
Results: In total, 482 patients were included. The number of inpatient stays increased from baseline by a mean of 0.52 (standard deviation [SD] 1.17) stays per radiation to bone event and the duration of stays increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD 7.46) procedures.
Conclusion: HRU increased following radiation to bone across all countries studied. Agents that prevent severe pain and delay the need for radiation have the potential to reduce the burden imposed on healthcare resources and patients
Pathologic fracture and healthcare resource utilisation: A retrospective study in eight European countries
Background Skeletal-related events (SREs; pathologic fracture [PF], spinal cord compression and radiation or surgery to bone) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems. In this study, the healthcare resource utilisation (HRU) associated with PFs in patients with bone metastases or lesions secondary to solid tumours or multiple myeloma was estimated in eight European countries. Methods Eligible patients were identified in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. HRU data were extracted from hospital charts from 3.5 months before the index PF (defined as a PF preceded by a 6.5-month period without a SRE) until 3 months after the last SRE during the study period. Changes from baseline in the number and duration of inpatient stays, number of outpatient visits and number of procedures provided were recorded. Results Overall, 118 patients with PFs of long bones (those longer than they are wide, e.g. the femur) and 241 patients with PFs of other bones were included. Overall, HRU was greater in patients with long bone PFs than in those with PFs of other bones. A higher proportion of patients with long bone PFs had multiple SREs (79.7%), and more of their SREs were considered to be linked (73.4%) compared with patients with PFs of other bones (51.0% and 47.2%, respectively). Conclusion The increased number and duration of inpatient stays for PFs of long bones compared with those for PFs of other bones may be due in part to the requirement for complicated and lengthy rehabilitation in patients with long bone PFs. Implementing strategies to delay or reduce the number of PFs experienced by patients with bone metastases or lesions may therefore reduce the associated HRU and patient burden.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
A retrospective study in eight European countries
Background Skeletal-related events (SREs; pathologic fracture [PF], spinal cord compression and radiation or surgery to bone) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems. In this study, the healthcare resource utilisation (HRU) associated with PFs in patients with bone metastases or lesions secondary to solid tumours or multiple myeloma was estimated in eight European countries. Methods Eligible patients were identified in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. HRU data were extracted from hospital charts from 3.5 months before the index PF (defined as a PF preceded by a 6.5-month period without a SRE) until 3 months after the last SRE during the study period. Changes from baseline in the number and duration of inpatient stays, number of outpatient visits and number of procedures provided were recorded. Results Overall, 118 patients with PFs of long bones (those longer than they are wide, e.g. the femur) and 241 patients with PFs of other bones were included. Overall, HRU was greater in patients with long bone PFs than in those with PFs of other bones. A higher proportion of patients with long bone PFs had multiple SREs (79.7%), and more of their SREs were considered to be linked (73.4%) compared with patients with PFs of other bones (51.0% and 47.2%, respectively). Conclusion The increased number and duration of inpatient stays for PFs of long bones compared with those for PFs of other bones may be due in part to the requirement for complicated and lengthy rehabilitation in patients with long bone PFs. Implementing strategies to delay or reduce the number of PFs experienced by patients with bone metastases or lesions may therefore reduce the associated HRU and patient burden.publishersversionpublishe
Pathologic fracture and healthcare resource utilisation: A retrospective study in eight European countries
Background: Skeletal-related events (SREs; pathologic fracture [PF],
spinal cord compression and radiation or surgery to bone) are common
complications of bone metastases or bone lesions and can impose a
considerable burden on patients and healthcare systems. In this study,
the healthcare resource utilisation (HRU) associated with PFs in
patients with bone metastases or lesions secondary to solid tumours or
multiple myeloma was estimated in eight European countries.
Methods: Eligible patients were identified in Austria, the Czech
Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. HRU
data were extracted from hospital charts from 3.5 months before the
index PF (defined as a PF preceded by a 6.5-month period without a SRE)
until 3 months after the last SRE during the study period. Changes from
baseline in the number and duration of inpatient stays, number of
outpatient visits and number of procedures provided were recorded.
Results: Overall, 118 patients with PFs of long bones (those longer than
they are wide, e.g. the femur) and 241 patients with PFs of other bones
were included. Overall, HRU was greater in patients with long bone PFs
than in those with PFs of other bones. A higher proportion of patients
with long bone PFs had multiple SREs (79.7%), and more of their SREs
were considered to be linked (73.4%) compared with patients with PFs of
other bones (51.0% and 47.2%, respectively).
Conclusion: The increased number and duration of inpatient stays for PFs
of long bones compared with those for PFs of other bones may be due in
part to the requirement for complicated and lengthy rehabilitation in
patients with long bone PFs. Implementing strategies to delay or reduce
the number of PFs experienced by patients with bone metastases or
lesions may therefore reduce the associated HRU and patient burden
Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
Background: Bone metastases and lytic lesions due to multiple myeloma
are common in advanced cancer and can lead to debilitating complications
(skeletal-related events [SREs]), including requirement for radiation
to bone. Despite the high frequency of radiation to bone in patients
with metastatic bone disease, our knowledge of associated healthcare
resource utilization (HRU) is limited.
Methods: This retrospective study estimated HRU following radiation to
bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal,
Sweden and Switzerland. Eligible patients were >= 20 years old, had bone
metastases secondary to breast, lung or prostate cancer, or bone lesions
associated with multiple myeloma, and had received radiation to bone
between 1 July 2004 and 1 July 2009. HRU data were extracted from
hospital patient charts from 3.5 months before the index SRE (radiation
to bone preceded by a SRE-free period of >= 6.5 months) until 3 months
after the last SRE that the patient experienced during the study period.
Results: In total, 482 patients were included. The number of inpatient
stays increased from baseline by a mean of 0.52 (standard deviation
[SD] 1.17) stays per radiation to bone event and the duration of stays
increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased
by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD
7.46) procedures.
Conclusion: HRU increased following radiation to bone across all
countries studied. Agents that prevent severe pain and delay the need
for radiation have the potential to reduce the burden imposed on
healthcare resources and patients
Health resource utilization associated with skeletal-related events: results from a retrospective European study
BACKGROUND Bone complications, also known as skeletal-related events (SREs), are common in patients with bone metastases secondary to advanced cancers. OBJECTIVE To provide a detailed estimate of the health resource utilization (HRU) burden associated with SREs across eight European countries. METHODS Eligible patients from centers in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone metastases or lesions secondary to breast cancer, prostate, or lung cancer or multiple myeloma who had experienced at least one SRE (defined as radiation to bone, long-bone pathologic fracture, other bone pathologic fracture, surgery to bone or spinal cord compression) were entered into this study. HRU data were extracted retrospectively from the patients' charts from 3.5 months before the index SRE until 3 months after the index SRE (defined as an SRE preceded by an SRE-free period of at least 6.5 months). RESULTS Overall, the mean number of inpatient stays per SRE increased from baseline by approximately 0.5-1.5 stays, with increases in the total duration of inpatient stays of approximately 6-37 days per event. All SREs were associated with substantial increases from baseline in the frequency of procedures and the number of outpatient and day-care visits. CONCLUSIONS SREs are associated with substantial HRU owing to considerable increases in the number and duration of inpatient stays, and in the number of procedures, outpatient visits, and day-care visits. These data collectively provide a valuable summary of the real-world SRE burden on European healthcare systems
Health resource utilization associated with skeletal-related events: results from a retrospective European study
Background Bone complications, also known as skeletal-related events
(SREs), are common in patients with bone metastases secondary to
advanced cancers.
Objective To provide a detailed estimate of the health resource
utilization (HRU) burden associated with SREs across eight European
countries.
Methods Eligible patients from centers in Austria, the Czech Republic,
Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone
metastases or lesions secondary to breast cancer, prostate, or lung
cancer or multiple myeloma who had experienced at least one SRE (defined
as radiation to bone, long-bone pathologic fracture, other bone
pathologic fracture, surgery to bone or spinal cord compression) were
entered into this study. HRU data were extracted retrospectively from
the patients' charts from 3.5 months before the index SRE until 3 months
after the index SRE (defined as an SRE preceded by an SRE-free period of
at least 6.5 months).
Results Overall, the mean number of inpatient stays per SRE increased
from baseline by approximately 0.5-1.5 stays, with increases in the
total duration of inpatient stays of approximately 6-37 days per event.
All SREs were associated with substantial increases from baseline in the
frequency of procedures and the number of outpatient and day-care
visits.
Conclusions SREs are associated with substantial HRU owing to
considerable increases in the number and duration of inpatient stays,
and in the number of procedures, outpatient visits, and day-care visits.
These data collectively provide a valuable summary of the real-world SRE
burden on European healthcare systems