Association of nitrosative and oxidative stress in young type 2 diabetic patients

Background: Nitric oxide levels play an important role in the pathogenesis of endothelial dysfunction in type 2 diabetes mellitus (DM). Aim of the study was to assess the association between serum nitric oxide levels (NOx), Oxidant load (FOX2) and total antioxidant status (FRAP) with fasting blood sugar (FBS)  in type 2 diabetic patients.Methods: Serum concentration NOx was measured by Griess method in seventy six type 2 diabetic patients with age & sex matched (aged 45-65yrs) controls. Serum total oxidant load was estimated by Ferrous oxidation product in xylenol orange version 2 (FOX2), total antioxidant status by ferric reducing capacity of serum (FRAP) .FBS was estimated by commercial kits adapted to autoanalyser.Results: Significant difference was observed in serum NO level between patients and controls (78.6+ 8.6 vs. 37.59+ 4.19μmol/L: p<0.000). Significantly high FOX 2 levels (12.4+ 2.6μmol/L vs. 4.33+ 1.7 μmol/L) and lower FRAPS level was observed in patients as compared to controls (61.37+31.64 μmol/L vs. 226.46+ 15.23 μmol/L).Conclusions: Hyperglycemia leads to nitrosative stress (increase NO level) and oxidative stress by increasing total oxidant load (FOX2), decreasing antioxidant capacity (FRAP)

Differential Occurrence of Cuticular Wax and Its Role in Leaf Physiological Mechanisms of Three Edible Aroids of Northeast India

The localization of cuticular wax (CW) on the leaf epidermis and its interaction with the physiological mechanisms of three edible aroids, Alocasia, Colocasia, and Xanthosoma, were assessed. CW in the leaf tissues was visualized using scanning electron microscopy, which was higher in Colocasia (10.61 mg·dm−2) and Xanthosoma (11.36 mg·dm−2) than in Alocasia (1.36 mg·dm−2). Colocasia CW exhibited superhydrophobic properties with a higher static contact angle (CA) (>150◦) than Xanthosoma (99.0◦) and Alocasia (128.7◦). The higher CW in Colocasia and Xanthosoma resulted in better leaf chlorophyll stability, moisture retention ability, and cellular membrane integrity compared to Alocasia. CW acted as a protecting barrier against deleterious solar radiation in terms of sun protection factor (SPF). The glossy appearance of wax crystals in the Alocasia leaf cuticles resulted in higher SPF. Overall, Colocasia CW highly influenced the qualitative and protective mechanisms of the leaf. Our study sheds light on the pivotal role of CW in the physiological properties of aroid leaves, which would be useful for the selection of wax-rich plants for augmenting future breeding strategies. The information would also be useful for further exploration of the industrial potential of superhydrophobic wax crystals obtained from edible aroids.Fil: Pieniazek, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. ICAR Research Complex for North Eastern Hill Region; IndiaFil: Dasgupta, Madhumita. ICAR Research Complex for North Eastern Hill Region; IndiaFil: Messina, Valeria Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; ArgentinaFil: Devi, Mayengbam Premi. ICAR Research Complex for North Eastern Hill Region; IndiaFil: Devi, Yumnam Indrani. ICAR Research Complex for North Eastern Hill Region; IndiaFil: Mohanty, Sansuta. ICAR-Indian Institute of Horticultural Research; IndiaFil: Singh, Satyapriya. ICAR-Indian Institute of Horticultural Research; IndiaFil: Sahoo, Bibhuti Bhusan. Odisha University of Agriculture and Technology; IndiaFil: Nongdam, Potshangbam. Manipur University; IndiaFil: Acharya, Gobinda Chandra. ICAR-Indian Institute of Horticultural Research; IndiaFil: Sahoo, Manas Ranjan. ICAR-Indian Institute of Horticultural Research; India. ICAR Research Complex for North Eastern Hill Region; Indi

Spatial Cognitive Implications of Teleporting Through Virtual Environments

Teleporting is a popular interface to allow virtual reality users to explore environments that are larger than the available walking space. When teleporting, the user positions a marker in the virtual environment and is instantly transported without any self-motion cues. Five experiments were designed to evaluate the spatial cognitive consequences of teleporting and to identify environmental cues that could mitigate those costs. Participants performed a triangle completion task by traversing 2 outbound path legs before pointing to the unmarked path origin. Locomotion was accomplished via walking or 2 common implementations of the teleporting interface distinguished by the concordance between movement of the body and movement through the virtual environment. In the partially concordant teleporting interface, participants teleported to translate (change position) but turned the body to rotate. In the discordant teleporting interface, participants teleported to translate and rotate. Across all 5 experiments, discordant teleporting produced larger errors than partially concordant teleporting which produced larger errors than walking, reflecting the importance of translational and rotational self-motion cues. Furthermore, geometric boundaries (room walls or a fence) were necessary to mitigate the spatial cognitive costs associated with teleporting, and landmarks were helpful only in the context of a geometric boundary

Comparative study of antimicrobial prescribing pattern between Nepal and Pakistan

Objective The purpose of this cross-sectional study conducted in different private and public sector hospitals of the major cities of Nepal and Pakistan was to compare and evaluate the antibiotic prescribing patterns. Methodology &nbsp;The data was collected based on prescriptions received from different hospitals of Lahore, Pakistan and Kathmandu, Nepal without much interaction with the patients. Results Out of a total of 272 patients, 111 (40.8%) patients from Nepal and 161 (59.19%) patients from Pakistan were prescribed with 447 antibiotics. In both countries, out of total antibiotics prescribed, 42.30% were 3rd generation cephalosporins. Also, in Pakistan and Nepal, out of all the indications, 49.2% of the antibiotics were given in medical prophylaxis. Conclusion &nbsp;In Pakistan, the antimicrobial prescription rate is comparatively higher than Nepal, and in both countries, there is a need of proper implementation of antibiotic prescribing guidelines for the prescription of antibiotics and the administration of antibiotics in medical prophylaxis

NT-proBNP changes in patients with ascites during large volume paracentesis

N-terminal probrain natriuretic peptide (NT-proBNP) is a hormone involved in the regulation of cardiovascular homeostasis. Changes in serum NT-proBNP during large volume paracentesis (LVP) in patients with ascites have never before been examined. Aims. To determine if significant changes in serum NT-proBNP occur in patients undergoing LVP and the associated clinical correlates in patients with cirrhosis. Method. A total of 45 patients with ascites were prospectively recruited. Serum NTproBNP, biochemistry, and haemodynamics were determined at baseline and at key time points during and after paracentesis. Results. 34 patients were analysed; 19 had ascites due to cirrhosis and 15 from malignancy. In those with cirrhosis, NT-proBNP decreased by 77.3 pg/mL at 2 L of drainage and 94.3 pg/mL at the end of paracentesis, compared with an increase of 10.5 pg/mL and 77.2 pg/mL in cancer patients at the same time points ( = 0.05 and = 0.03). Only congestive cardiac failure (CCF) was an independent predictor of significant NT-proBNP changes at the end of drainage in cirrhotic patients ( < 0.01). There were no significant changes in haemodynamics or renal biochemistry for either group. Conclusion. Significant reductions in serum NTproBNP during LVP occur in patients with cirrhosis but notmalignancy, and only comorbid CCF appeared to predict such changes

Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)

The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the India-based Neutrino Observatory (INO) is designed to study the atmospheric neutrinos and antineutrinos separately over a wide range of energies and path lengths. The primary focus of this experiment is to explore the Earth matter effects by observing the energy and zenith angle dependence of the atmospheric neutrinos in the multi-GeV range. This study will be crucial to address some of the outstanding issues in neutrino oscillation physics, including the fundamental issue of neutrino mass hierarchy. In this document, we present the physics potential of the detector as obtained from realistic detector simulations. We describe the simulation framework, the neutrino interactions in the detector, and the expected response of the detector to particles traversing it. The ICAL detector can determine the energy and direction of the muons to a high precision, and in addition, its sensitivity to multi-GeV hadrons increases its physics reach substantially. Its charge identification capability, and hence its ability to distinguish neutrinos from antineutrinos, makes it an efficient detector for determining the neutrino mass hierarchy. In this report, we outline the analyses carried out for the determination of neutrino mass hierarchy and precision measurements of atmospheric neutrino mixing parameters at ICAL, and give the expected physics reach of the detector with 10 years of runtime. We also explore the potential of ICAL for probing new physics scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration, Contents identical with the version published in Pramana - J. Physic

Computational Support for Game Masters of Tabletop Roleplaying Games

In tabletop roleplaying games (TTRPGs), game masters (GMs) facilitate shared story creation using improvisational techniques that let them anticipate and respond to what players want to see in the world. In order to examine the process by which GMs co-create such player-driven narratives, we conduct interviews with GMs about their process preparing for and running TTRPG campaigns. We qualitatively code these interviews in order to synthesize a list of techniques GMs use to move the story forward even when players behave unexpectedly. We then perform a second round of interviews, looking at how GMs would run a specific scenario (\textit{Lost Mine of Phandelver}) and using this as a common baseline for understanding GMing techniques. We also provide GMs with a limited prototype of a digital tool for GMs and use this in our interviews to evaluate what GMs might want to see in a computational assistant. We compare our interview findings to online advice for running \textit{Lost Mine} in order to see if these techniques were shared across a wider sample of GMs. Based on these interviews and analysis, we provide some speculative directions for further designs of computational tools for GMs, such as creating better tools for information visualization and generative content