15 research outputs found

    Extraction and Screening of Biofilm producing Bacterial isolates in Short-and Long-term Catheters

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    Biofilm is defined as microbial-derived sessile communities enclosed with extra polymeric substances and characterized by cells that are irreversibly attached to a surface. Biofilm bacteria are a serious threat to public health as biofilm formation of bacteria in indwelling medical devices especially in urinary catheters causes persistent infections resistant to treatment with antimicrobial agents. The present study focused to screen the biofilm-producing bacteria from the indwelling urinary catheters.  Both short-term and long-term urinary catheters were collected from the catheterized patients admitted in the national and a private hospital. Bacterial population removed from the catheters were tested for biofilm production by widely used three methods such as Tube method, Congo Red Agar method, and Tissue Culture Plate method. In this preliminary screening, the major biofilm producer identified in the present study is E.Coli in all types of catheters.  Further, biofilm-producing bacteria were predominantly detected in long-term catheters than short-term catheters. In addition, the identification of more than one bacterial strain in long-term catheters revealed that bacterial diversity increases with the duration of catheterization. The results of the present study revealed that long-term urinary catheters have the potential for survival and diverse biofilm-producing bacteria

    ArrayExpress update—an archive of microarray and high-throughput sequencing-based functional genomics experiments

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    The ArrayExpress Archive (http://www.ebi.ac.uk/arrayexpress) is one of the three international public repositories of functional genomics data supporting publications. It includes data generated by sequencing or array-based technologies. Data are submitted by users and imported directly from the NCBI Gene Expression Omnibus. The ArrayExpress Archive is closely integrated with the Gene Expression Atlas and the sequence databases at the European Bioinformatics Institute. Advanced queries provided via ontology enabled interfaces include queries based on technology and sample attributes such as disease, cell types and anatomy

    An information technology (it) approach in developing a solution to a local environmental problem

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    Solid waste (mis)management is one of the most serious local environmental problems in Sri Lanka (Figure 1). It has become a big threat to public health, the beautiful environment and a burden to the national economy

    Case Reports Acute renal failure following multiple wasp bites

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    (Key words: wasp bites, acute renal failure

    BESTCOMP: expert system for Sri Lankan solid waste composting

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    A user friendly expert system, BESTCOMP was developed for better management of solid waste composting by local authorities in Sri Lanka. BESTCOMP expert system mainly focussed on the behaviour of the physical, chemical and biological process in composting. The intention had been to provide distant users with scientific and techno-economic information using modern tools but at a much lower cost. This research has put very strong emphasis on allowing the user to browse around the knowledge that has being extracted from books, published research articles, reports, audio, video, Internet, case studies and the domain experts who involved in solid waste management activities, so the user can get an accurate and a real feel for the solid waste management subject

    Development of an expert system for better management of solid waste composting by pradeshiya sabhas in Sri Lanka

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    The increasing population and the ever-changing life style of the public have begun to add to the growing solid waste problem in Sri Lanka. As a solution, Local Authorities, NGOs, researchers and environmentalists have implemented several composting projects. Unfortunately, most of these projects are either abandoned or operating under poor conditions due to social, economic and technical problems encountered and none of options have solved the solid waste management problem itself. A key issue that is highlighted is the lack of qualified personnel (experts) to advise and assist Local Authorities to adopt the best solid waste management practices. Decision Support Systems and Expert Systems are favourable tools to overcome these problems. Therefore by capturing past mistakes, weak points and considering past experience, a user friendly Expert System called BESTCOMP was developed for better management of solid waste composting by Pradeshiya Sabhas in Sri Lanka. This research mainly focused on the behaviour of the physical, chemical and biological process in composting. The model is geared towards decision making as well as providing required expertise to solid waste composting hierarchy

    ArrayExpress update—from an archive of functional genomics experiments to the atlas of gene expression

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    Original article can be found at: http://nar.oxfordjournals.org/ Copyright the Author(s) DOI: 10.1093/nar/gkn889 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/UK/)which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.ArrayExpress http://www.ebi.ac.uk/arrayexpress consists of three components: the ArrayExpress Repository—a public archive of functional genomics experiments and supporting data, the ArrayExpress Warehouse—a database of gene expression profiles and other bio-measurements and the ArrayExpress Atlas—a new summary database and meta-analytical tool of ranked gene expression across multiple experiments and different biological conditions. The Repository contains data from over 6000 experiments comprising approximately 200 000 assays, and the database doubles in size every 15 months. The majority of the data are array based, but other data types are included, most recently—ultra high-throughput sequencing transcriptomics and epigenetic data. The Warehouse and Atlas allow users to query for differentially expressed genes by gene names and properties, experimental conditions and sample properties, or a combination of both. In this update, we describe the ArrayExpress developments over the last two years.Peer reviewe
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