7,634 research outputs found
Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells. In order to differentiate between the direct effects of FSH on spermatogenesis and those mediated indirectly through androgen action we have crossed hypogonadal (hpg) mice which lack gonadotrophins with mice lacking androgen receptors (AR) either ubiquitously (ARKO) or specifically on the Sertoli cells (SCARKO). These hpg.ARKO and hpg.SCARKO mice were treated with recombinant FSH for 7 days and testicular morphology and cell numbers assessed. In untreated hpg and hpg.SCARKO mice germ cell development was limited and did not progress beyond the pachytene stage. In hpg.ARKO mice testes were smaller with fewer Sertoli cells and germ cells compared to hpg mice. Treatment with FSH had no effect on Sertoli cell number but significantly increased germ cell numbers in all groups. In hpg mice FSH increased numbers of spermatogonia and spermatocytes and induced round spermatid formation. In hpg.SCARKO and hpg.ARKO mice, in contrast, only spermatogonial and spermatocyte numbers were increased with no formation of spermatids. Leydig cell numbers were increased by FSH in hpg and hpg.SCARKO mice but not in hpg.ARKO mice. Results show that in rodents 1) FSH acts to stimulate spermatogenesis through an increase in spermatogonial number and subsequent entry of these cells into meiosis, 2) FSH has no direct effect on the completion of meiosis and 3) FSH effects on Leydig cell number are mediated through interstitial ARs
Meta-stable SUSY Breaking Model in Supergravity
We analyze a supersymmetry (SUSY) breaking model proposed by Intriligator,
Seiberg and Shih in a supergravity (SUGRA) framework. This is a simple and
natural setup which demands neither extra superpotential interactions nor an
additional gauge symmetry. In the SUGRA setup, the U(1)R symmetry is explicitly
broken by the constant term in the superpotential, and pseudo-moduli field
naturally takes non-zero vacuum expectation value through a vanishing
cosmological constant condition. Sfermions tend to be heavier than gauginos,
and the strong-coupling scale is determined once a ratio of sfermion to gaugino
masses is fixed.Comment: 13 page
Solitonic supersymmetry restoration
Q-balls are a possible feature of any model with a conserved, global U(1)
symmetry and no massless, charged scalars. It is shown that for a broad class
of models of metastable supersymmetry breaking they are extremely influential
on the vacuum lifetime and make seemingly viable vacua catastrophically short
lived. A net charge asymmetry is not required as there is often a significant
range of parameter space where statistical fluctuations alone are sufficient.
This effect is examined for two supersymmetry breaking scenarios. It is found
that models of minimal gauge mediation (which necessarily have a messenger
number U(1)) undergo a rapid, supersymmetry restoring phase transition unless
the messenger mass is greater than 10^8 GeV. Similarly the ISS model, in the
context of direct mediation, quickly decays unless the perturbative
superpotential coupling is greater than the Standard Model gauge couplings.Comment: 17 pages, 3 figures, minor comments added, accepted for publication
in JHE
Fermion Masses and Mixing in Four and More Dimensions
We give an overview of recent progress in the study of fermion mass and
flavor mixing phenomena. Mass matrix ansatze are considered within the SM and
SUSY GUTs where some predictive frameworks based on SU(5) and SO(10) are
reviewed. We describe a variety of schemes to construct quark mass matrices in
extra dimensions focusing on four major classes: models with the SM residing on
3-brane, models with universal extra dimensions, models with split fermions and
models with warped extra dimensions. We outline how realistic patterns of quark
mass matrices could be derived from orbifold models in heterotic superstring
theory. Finally, we address the fermion mass problem in intersecting D-branes
scenarios, and present models with D6-branes able to give a good quantitatively
description of quark masses and mixing. The role of flavor/CP violation problem
as a probe of new physics is emphasized.Comment: a review based on seminars presented by S.K. in different places, 34
pages, late
Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4+ Foxp3+ regulatory T cells
Recently, we demonstrated elevated numbers of CD4(+) Foxp3(+) regulatory T (Treg) cells in Plasmodium yoelii‐infected mice contributing to the regulation of anti‐malarial immune response. However, it remains unclear whether this increase in Treg cells is due to thymus‐derived Treg cell expansion or induction of Treg cells in the periphery. Here, we show that the frequency of Foxp3(+) Treg cells expressing neuropilin‐1 (Nrp‐1) decreased at early time‐points during P. yoelii infection, whereas percentages of Helios(+) Foxp3(+) Treg cells remained unchanged. Both Foxp3(+) Nrp‐1(+) and Foxp3(+) Nrp‐1(−) Treg cells from P. yoelii‐infected mice exhibited a similar T‐cell receptor Vβ chain usage and methylation pattern in the Treg‐specific demethylation region within the foxp3 locus. Strikingly, we did not observe induction of Foxp3 expression in Foxp3(−) T cells adoptively transferred to P. yoelii‐infected mice. Hence, our results suggest that P. yoelii infection triggered expansion of naturally occurring Treg cells rather than de novo induction of Foxp3(+) Treg cells
Meta-Stable Brane Configuration with Orientifold 6 Plane
We present the intersecting brane configuration of type IIA string theory
corresponding to the meta-stable nonsupersymmetric vacua in four dimensional
N=1 supersymmetric SU(N_c) gauge theory with a symmetric flavor, a conjugate
symmetric flavor and fundamental flavors. By studying the previously known
supersymmetric M5-brane curve, the M-theory lift for this type IIA brane
configuration, which consists of NS5-branes, D4-branes, D6-branes and an
orientifold 6-plane, is analyzed.Comment: 21 pp, 3 colored figures; stability arguments added in page 11 and
12, a typo in figure 3 corrected, and to appear in JHE
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