Knock Down of Heat Shock Protein 27 (HspB1) Induces Degradation of Several Putative Client Proteins

Hsp27 belongs to the heat shock protein family and displays chaperone properties in stress conditions by holding unfolded polypeptides, hence avoiding their inclination to aggregate. Hsp27 is often referenced as an anti-cancer therapeutic target, but apart from its well-described ability to interfere with different stresses and apoptotic processes, its role in non-stressed conditions is still not well defined. In the present study we report that three polypeptides (histone deacetylase HDAC6, transcription factor STAT2 and procaspase-3) were degraded in human cancerous cells displaying genetically decreased levels of Hsp27. In addition, these proteins interacted with Hsp27 complexes of different native size. Altogether, these findings suggest that HDAC6, STAT2 and procaspase-3 are client proteins of Hsp27. Hence, in non stressed cancerous cells, the structural organization of Hsp27 appears to be a key parameter in the regulation by this chaperone of the level of specific polypeptides through client-chaperone type of interactions

Firsts lysidinyl- and lysidinium-triphosphines Pd(II) complexes

International audienceThe preparation of first lysidinyl-triphosphine ligand (named Triphosline) is described in three steps which are first a Michael type addition of imidazolidine (or lysidine) to diethylvinylphosphonate, second a phosphonate reduction with LiAlH4 and third an anti-Markovnikov radical addition of the primary phosphine to diphenylvinylphosphine. The Triphosline behaves as a tridentate P-coordinating ligand in palladium(II) complexes. The dangling lysidine function is then cleanly and totally alkylated by methyl iodide to lead to a new kind of lysidinium-triphosphine complexes. Subsequent anion exchange with TlPF6 affords the first example of a chloride free lysidinium-triphosphine palladium complex which has been fully characterized by spectroscopic and analytical methods

Education du chien d'assistance aux personnes handicapées (rôles et compétences de l'éducateur canin : application à l'ANECAH)

LYON1-BU Santé (693882101) / SudocSudocFranceF

L-Rose: a model simulating organ expansion of individual plants within a bush rose crop

poster abstract. avec actesEds. Risto Sievänen, Eero Nikinmaa, Christophe Godin, Anna Lintunen , Pekka NygrenA model has been developed to simulate the dynamics of expansion of the individual organs ofbush rose primary shoots. This model is designed to provide a tool calibrated on experimental data toinvestigate plant response to phylloclimate, especially light

En busca del Clásico temprano: la temporada 2015 del Proyecto Naachtun (2015-2018) Peten

International audienc

Una mirada hacia Naachtun después de cinco años de investigación (Proyecto Naachtun 2010-2014)

International audience"In 2014 ended the Naachtun Proyect’s first phase of investigations. During five years, it focused mainly on the characterization of the site social, political, and economic organization during the period of apogee of this regional major Center, that is the Late and Terminal Classic periods, during which Naachtun’s population reached its peak. In this paper, we will emphasize the main results in terms of knowledge of Naachtun’s history, giving priority to the most recent progress and discoveries of the 2014 field season, in the archaeological as well as in the paleo-environmental fields." (source éditeur)Voir le site de l'association Tikal pour lire le document en ligne ou télécharger le document

La temporada 2017 del Proyecto Naachtun (2015-2018)

International audienc

La temporada 2013 del Proyecto Naachtun: primeros resultados

International audience"The 2013 season of Proyecto Naachtun marks a gradual shift in the research issues about time periods and aspects less understood at the date. This paper will focus on the early classic period, when the site has been set, and will deal with the results of the different operations developed both in the monumental core and the periphery. Particular attention will be given to the late classic elite residences, especially in the Group B. Finally, in 2013, the first results of the epigraphic works will be given, to explain the political history and relate archaeology and inscriptions. Finally, we will try to offer a complete view of the results obtained both in the field and in laboratory." (source éditeur)Voir le site de l'association Tikal pour lire le document en ligne ou télécharger le document