Exploring Current Practice of Using Technology to Support Collaborative Argumentation in Science Classrooms

The purpose of this qualitative study was to explore how middle school science teachers enact the practice of using technology to support collaborative argumentation in their science classroom. This study employed qualitative case study and drew on data sources of interviews and observations. This study identified two themes. Six teachers regarded scientific argumentation as an important science practice, but five of them integrated this practice into their science class without formally introducing it. All teachers integrated different forms of technology to engage students in scientific argumentation. In this study, the findings suggested there is a need to provide professional development for teachers to learn about scientific argumentation. The findings can be used as a basis for the design and development of professional development training experiences for in-servic

Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress

Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction. We now provide scientific support for its alternative use in the management of priapism, a clinical disorder of prolonged and uncontrolled penile erection. Sildenafil administered continuously to sickle cell mice, which show a priapism phenotype, reverses oxidative/nitrosative stress effects in the penis, mainly via reversion of uncoupled endothelial nitric oxide synthase to the functional coupled state of the enzyme, which in turn corrects aberrant signaling and function of the nitric oxide/cyclic GMP/protein kinase G/phosphodiesterase type 5 cascade. Priapism tendencies in these mice are reverted partially toward normal neurostimulated erection frequencies and durations after sildenafil treatment in association with normalized cyclic GMP concentration, protein kinase G activity and phosphodiesterase type 5 activity in the penis. Thus, sildenafil exerts pleiotropic effects in the penis that extend to diverse erection disorders. © 2013 Bivalacqua et al

A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies

Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies

Measurement of branching fraction and direct CP asymmetry in charmless B+ → K+K−π + decays at Belle

We report a study of the charmless hadronic decay of the charged B meson to the three-body final state K+K−π+. The results are based on a data sample that contains 772×106  B¯B pairs collected at the Υ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e− collider. The measured inclusive branching fraction and direct CP asymmetry are (5.38±0.40±0.35)×10−6 and −0.170±0.073±0.017, respectively, where the first uncertainties are statistical and the second are systematic. The K+K− invariant mass distribution of the signal candidates shows an excess in the region below 1.5  GeV/c2, which is consistent with the previous studies from BABAR and LHCb. In addition, strong evidence of a large direct CP asymmetry is found in the low K+K− invariant-mass region

Effects of Recombinant Human Bone Morphogenetic Proteinâ 2 on Vertical Bone Augmentation in a Canine Model

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141765/1/jper0896.pd

Feasibility study of achieving reliable electricity supply using hybrid power system for rural primary schools in Iraq: a case study with umm qasr primary school

Electrical power is considered as a significant part of contemporary life, and an essential element for development. Fossil fuels have been utilized since the beginning of the twentieth century for electricity generation. However, fossil fuels depletion at the escalating pace as well as their formidable negative implications upon ecosystem contributed to increasing interest in harnessing renewable energy sources for producing electric power to meet the growing demand worldwide. In Iraq, the electrical supply is not sufficient to supply 12 hours a day of electricity. Many rural areas, particularly their schools are suffering from the electricity shortage such as Umm Qasr Primary School that located 20 km away from the city centre of Karbala city in the middle of Iraq. In order to overcome this issue, this paper proposes a hybrid system which relies on renewable resources and the local grid to electrify Umm Qasr Primary School. Various combinations of energy resources have been analysed by using HOMER software to estimate an optimum hybrid system. The analysis illustrates that the optimal configuration of the projected system is composed of 22.4 kW PV modules, 59 batteries, and 5738kWh purchased from the local grid which has reduced the net present cost(NPC)from US$163791 the current situation to US$60,420 for the proposed system. The simulation findings also demonstrate that detrimental emissions have been reduced significantly

Possible Quantum Spin Liquid States on the Triangular and Kagome Lattices

The frustrated spin-one-half Heisenberg model on triangualr and Kagome Lattices is mapped onto a single specis of fermion carrying statistical flux. The corresponding Chern-Simons gauge theory is analyzed at the Gaussian level and found to be massive. This provides a new motivation for the spin-liquid Kalmeyer-Laughlin wave function. Good overlap of this wave function with the numerical ground state is found for small clusters.Comment: 13 pages, revtex. IUCM-920