MEFV gene testing may guide physicians for early diagnosis of familial Mediterranean fever

IntroductionFamilial Mediterranean fever (FMF) is characterized by recurrent attacks of polyserositis. Even though clinical assessment is accepted to be the most important factor in the diagnosis of FMF, some diagnostic procedures may help the physician. In this study, we aimed to compare the number of diagnostic procedures performed and number of physician referrals in early diagnosed and late diagnosed cases. Furthermore, we assessed which diagnostic approaches would affect the decision-making of physicians in the early diagnosed patients

Gastrointestinal stromal tümörün multidisipliner tedavisinde cerrahinin yeri:

The role of surgery in multidisciplinary approach to gastrointestinal stromal tumors: A case reportNeşet Köksal1, Mehmet Ali Uzun1, Mehmet Aliustaoğlu2, Gamze Kılıçoğlu31S.B. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, 2. Genel Cerrahi Kliniği, İstanbul, Türkiye2S.B. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Tıbbi Onkoloji, İstanbul, Türkiye3S.B. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Radyoloji Kliniği, İstanbul, TürkiyeAbstractAlthough rare among tumors involving the gastrointestinal system, gastrointestinal stromal tumors are the most frequent mesenchymal tumors. Recommended treatment regimens need to be updated as the multidisciplinary approach to both diagnosis and treatment of the tumor gains importance. Surgery still holds place as the most important constituent of multidisciplinary in current algorythms and ongoing studies. Specific features of the surgical procedures and their combinations with other modalities are currently controversial issues. This study aims to discuss the role of surgery within such an approach, featuring a 62 year-old male patient having a gastrointestinal stromal tumor.Keywords:&nbsp;Gastrointestinal stromal tumor, surgical treatment, imatinib</p

The Injuries to Oral Cavity During The Year of 1996 in Istanbul, Turkey

&nbsp;The Injuries to Oral Cavity During The Year of 1996 in Istanbul,Turkey&nbsp;</div

The Effect of C-erbB-2 Expression on Clinical-Pathological Prognostic Factors and Survival Ratios in Urothelial Tumors

Introduction: Overexpression and the amplification of proto-oncogenic c-erythroblastic oncogene B (c-erbB-2) (HER-2/neu) encode transmembrane growth factor glycoprotein and are a part of the type I receptor tyrosine-protein kinase. It is known to play a role in the treatment of breast and stomach carcinomas. C-erbB-2 overexpression and amplification in urothelial carcinomas have also been demonstrated in many studies. However, possible treatment options and prognostic values are still not sufficiently defined. This study aims to determine the overexpression rate of c-erbB-2 in urothelial carcinomas. In ad dition, we sought to determine if there was a relationship between c-erbB-2 overexpression and clinical-pathological prog nostic factors, such as histological grade, pathological stage, lymph node and distant organ metastasis, and survival time. Methods: C-erbB2 overexpression was examined using an immunohistochemical method performed on paraffin block samples of patients diagnosed with primary bladder urothelial carcinoma (n=41). The relationship of the data obtained after this examination with classical clinical-pathological prognostic factors, such as histological grade, pathological stage, regional lymph node metastasis, distant organ metastasis, and survival, was investigated. The obtained data were evaluated statistically. The alpha significance value was 0.05. Results: C-erbB-2 overexpression was positive in 9.75% (4/41) of the cases. c-erbB-2-positive tumors were all found to be at a high level. One patient was in stage T2, one stage T3, and two in stage T4. Three positive cases had lymph node metastasis; one patient did not have lymph node metastasis. Remote organ metastasis was not observed in any positive cases, and all positive cases were reported to survive. The fact that 75% (3/4) of the positive cases were lymph node metastasis may contribute to the literature. Discussion and Conclusion: Standardized laboratory methods should be used and studied in large series, including more patients representing various races to evaluate c-erbB-2 overexpression and amplification status in urothelial tumors as a treatment option with prognostic value

A Rare Cause of Acute Renal Failure: Leriche Syndrome

A Rare Cause of Acute Renal Failure: Leriche SyndromeAkut Böbrek Yetmezliginin Nadir Bir Sebebi: Leriche SendromuSeydahmet Akın 1, Sinan Kazan 1, Bilge Kalkan 2, Mehmet Aliustaoğlu 1&nbsp;ABSTRACTLeriche Syndrome is characterized with occ-lusive atherom plaques at aortic bifurcation obs-tructing iliac arteries. Renal arteries are involvedin only 10% of patients. Renal artery involvementmay be a rare cause of renal impairment. We reporta Leriche sydrome case presenting with acute renalfailure.Key Words: atherosclerosis, Leriche syndrome, Re-nal insufficiency.&nbsp;</div