FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ANTIEPILEPTIC DRUG

Objective:  The objective of the present study was to prepare and evaluate the mouth dissolving tablet of lacosamide using super disintegrants like Guar Gum, and other excipients like microcrystalline cellulose and mannitol in different concentrations by direct compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for epilepsy patients. Methods: The mouth dissolving tablets were prepared by a single punch machine using a powder blend of super disintegrants and lacosamide. Post-compression parameters like hardness, weight variation, friability, in-vitro dispersion, drug content uniformity, and in-vitro drug release studies were carried out for all formulations. Results: All formulations results were within official limits. Fast disintegration time obtained between 35sec. and 128 sec, was within the official limit. Different drug release kinetic models were applied for selecting batches for stability studies. These showed that there was no significant change in residual drug content in mouth dissolving tablets. Conclusion: By the in-vitro disintegration, it is concluded that formulation prepared by Guar Gum (10%) showed faster disintegration time than that of MCC. This indicates that the use of super disintegrants increases the release of drug from the formulation. Therefore, it can be concluded that such mouth dissolving tablets are suitable delivery systems for lacosamide.                                               Peer Review History: Received 30 November 2019;   Revised 15 December; Accepted 4 January, Available online 15 January 2020 Academic Editor: Dr. Ali Abdullah Al-yahawi, Al-Razi university, Department of Pharmacy, Yemen, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 3.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Iman Muhammad Higazy, National Research Center, Egypt, [email protected] Dr. Mohamed Salama, Modern University for Technology & Information, Egypt, [email protected]  Similar Articles: FAST DISSOLVING DRUG DELIVERY SYSTEMS: FORMULATION, PREPARATION TECHNIQUES AND EVALUATION FAST DISSOLVING TABLETS: A PROMISING APPROACH FOR DRUG DELIVERY DEVELOPMENT AND EVALUATION OF FAST DISSOLVING THIN FILMS OF ARIPIPRAZOL

Formulation and Characterization of Mouth Dissolving Tablet of Antiepileptic Drug using Natural Superdisintegrants

MDTs is regarding as a good candidates for the patients with persistent nausea, who are traveling, or who have little or no access to water.  The objective of present research work was to prepare and evaluate the mouth dissolving tablet of Lacosamide using Super disintegrants like Guar Gum, and other excipients like Microcrystalline Cellulose and Mannitol in different concentrations by Direct Compression method. Lacosamide has been shown to be an effective antiepileptic agent appropriate for the epilepsy patients. Effect of different formulation variables i.e. amount of polymer and type of polymer was studied on release profile and other characteristics. The mouth dissolving tablets were prepared by single punch machine using powder blend of superdisintegrant and Lacosamide. Post-compression parameters like Hardness, weight variation, friability, In-Vitro dispersion, Drug content uniformity and In-vitro drug release studies were carried out for all the formulation. All the Formulations gave the result within the official limits. The prepared mouth dissolving tablet shows the properties of fast disintegration time (28 sec to 47 sec) within official limit.  By the in-vitro disintegration, it is concluded that formulation F2 prepared by Guar Gum (10%) showed the fast disintegration time than the MCC. Therefore, it may be concluded that mouth dissolving tablet was suitable choice for delivery system of Lacosamide. Keywords: Lacosamide, Mouth dissolving tablets, Superdisintegrants, Guargum, microcrystalline cellulose, Direct compression method, Antiepileptic drug

PHYTOCHEMICALS IN THE TREATMENT OF ARTHRITIS: CURRENT KNOWLEDGE

The objective of the present review is to evaluate the therapeutic potential of phytochemicals against arthritis, which is asymptomatic disorder of chronic joint inflammation followed by swelling and pain. Here, we discussed about the anti-arthritic activity of many phytomolecules such as Norisoboldine, Berberine, Triptolide, Hesperidin Hesperidin, Madecassocide, Hydroxy napthoquinone, Ginsenoside, Cryptotanshinone, Kirenol, Thymoquinone, Chlorogenic acid, Curcumin, Bromelain, Andrographolide and Allicin. These compounds are able to control inflammatory responses, proinflammatory cytokines, osteoclast differentiation and to prevent bone erosion in the joints. In this article, we reviewed anti-arthritic activities of phytichemicals from 2011-2019, using various scientific websites like PubMed, Google Scholar, Science Direct etc. Till date clinical trials conducted with anti-arthritic phytomolecules are very less. Hence, more clinical trials are needed to bring plant molecules as safe and effective anti-arthritic drugs in the market, either alone or in combination with other anti-arthritic agents

Overview of formulation & evaluation of fast dissolving tablet: A promising tablet dosage form

The science of drug delivery has been increasingly innovative and quick evolving with ever-increasing demand in the current scientific scenario. Fast dissolving tablet (FDT) is one of those forms of an advanced and special drug delivery system that is rapidly gaining a lot of attention in the rapid dissolution technology research sector. Fast dissolving tablets appear as one of the common and widely accepted dosage types, particularly for paediatric patients due to incomplete muscle and nervous system development and a form of geriatric patients with Parkinson's disease or hand shivering. The most popular administrative path for different medications has drawbacks such as first-pass metabolism, psychotic patients, bedridden and Uncollaborative patients, is the oral delivery type and oral path FDTs disintegrate or quickly dissolve in the saliva without requiring water. Within few seconds, FDT will dissolve within saliva for approximately 60 seconds and these comprises will dissolve even faste

Validation process of EDTA for infusion/ injection with ceftriaxone and sulbactam

The validation of the manufacturing process to produce ceftriaxone/ sulbactam with EDTA1.5 g/ vial powder for solution for injection/ infusion. Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell- wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in the formation of defective cell walls and cell death. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds the enzyme and does not allow it to interact with the antibiotic. The validation confirms that each stage of the manufacturing process is in control and will consistently produce a product of acceptable quality, as defined by the specifications of product. It is planned that operating variables and control parameters of processes shall be studied and documented. The associated critical product attributes and characteristics shall also be studied. Process validation of ceftriaxone/ sulbactam 1.5g/ vial powder for solution for injection. Process for manufacture of ceftriaxone/ sulbactam 1.5g/ vials powder for solution for injection/ infusion is said to be in state of control. Hence this product can be manufactured by using this process without modifying any parameter