On the effect of buoyancy on lateral migration of bubbles in turbulent flows insights from Direct Numerical Simulations

International audienceBubble migration is a key concern in turbulent bubbly flows as it dramatically affects momentum and mass transfers between phases. Its prediction in steam-water conditions relevant to PWR applications is difficult to assess because experiments are often conducted with air/water flows that present substantially different properties. The effect of the deformability of bubbles on the lift force has been extensively studied experimentally, or numerically, and characterized based on the Eotvos and Reynolds numbers. Nonetheless, the effect of buoyancy is not well understood. The strength of gravity and the resultant enhancement of turbulence can have a significant impact on bubble migration in the cross-flow direction.In this work, we propose to use Direct Numerical Simulations (DNS) of turbulent bubbly flows to better understand the dominant physical mechanisms at play and cover ranges of conditions difficult to access experimentally. DNS offers a rich insight into the underlying physical phenomena and allows us to control the relative importance of different sub-physics. Starting from the flow conditions studied by Lu and Tryggvason [1], we perform four DNS of bubbly flows at a slightly higher Reynolds friction number, covering deformable and almost-spherical bubbles in weakly-buoyant or buoyant conditions. Separate effects of the Eotvos number and of an increasing gravitational force are assessed. Mean quantities, Reynolds stresses and higher-order statistics are computed to analyze the effect of bubbles on liquid turbulence levels, which influences the wall-normal void fraction profile. New insights on the way bubbles alters liquid turbulence levels and influence the lateral migration of bubbles are presented. Further experimental and numerical studies are required to support and extend this analysis

The importance of the commons in the context of intellectual property

CITATION: Van Der Walt, A.J. & Du Bois, M. 2013. The importance of the commons in the context of intellectual property. Stellenbosch Law Review = Stellenbosch Regstydskrif 24(1):31-54.The original publication is available at https://journals.co.za/content/journal/ju_slrThe intellectual commons or public domain is an important part of intellectual property law scholarship. In this regard it is necessary to examine the origins of the commons, what exactly the intellectual commons is and how the notion of the intellectual commons may be further developed. Especially in the United States of America there are concerns that the intellectual commons is currently being enclosed by extending intellectual property protection to areas of intellectual activity that were previously excluded from propertisation; and by extending intellectual property protection of existing rights. It may be argued that some intellectual products should remain in the commons or revert back to the commons in order to ensure that enough remains so that new intellectual products may be developed based on these existing products. However, there must also be enough of a property-right based incentive in order to ensure continued investment in the creation of new intellectual products. The important question is then, how may these two interests be balanced? This article examines the issues related to the commons in order to provide a framework which future revisions to intellectual property legislation may use as a point of departure to ensure that South African legislation does not encroach on the intellectual commons unduly. Examples from copyright law, patent law and traditional knowledge are used to demonstrate how the intellectual commons and intellectual property statutes interact.Publishers versio

Effect of xylopic acid on alloxan-induced diabetic neuropathy in rats

Background: Neuropathic pain is a very disturbing condition commonly found in diabetic patients. This study investigated xylopic acid (XA), the major constituent of Xylopia aethiopica in diabetic neuropathy as well as established possible toxicity of the compound on some selected tissues.Methods: Diabetes was induced in six groups of male rats with 120 mg/kg alloxan monohydrate. Diabetes was confirmed as a blood glucose level >15 mmol/dl. Neuropathic pain was confirmed on day three post-diabetes induction and treatment with 10 mg/kg, 30 mg/kg or 100 mg/kg xylopic acid, 10 mg/kg glibenclamide, 10 mg/kg morphine, and 10 ml/kg normal saline were initiated and continued for the next 15 days. The effects of the treatments on cold allodynia (cold water at 4°C) and thermal hyperalgesia (hot water at 55 ± 1°C) were evaluated within the duration of treatments. Histology of the liver and kidney, as well as haematological, serum biochemical, and semen analyses, were done after the fifteenth day of the experiment.Results: Xylopic acid produced significant anti-hyperglycaemic and analgesic effects in the cold allodynia and thermal hyperalgesia tests. Sperm motility, viability and count were significantly restored at 10 mg/kg XA as compared higher doses and negative control. The outcome of haematological analysis revealed a protective effect of XA although histological damage liver and kidney due to alloxan treatment was observable.Conclusions: Xylopic acid ameliorates diabetic neuropathy in rats and does not exert detrimental effects at low doses

Life Cycle of Multi Technology Machine Tools – Modularization and Integral Design

AbstractFor reasons of high flexibility but still maximum productivity, machine tools integrating various production technologies have recently received particular attention. Combining and integrating multiple manufacturing techniques into one single system in early stages of the product emergence process is challenging. To keep the effort for implementation to a minimum, an initiation already in the concept phase is being actively pursued. Design guidelines are currently investigated based on the examination of different technology combinations.This approach focuses on systematic conceptual design for such hybrid machine technologies. Product architectures are used to describe the modularity and create a specific delimitation for standardization. Reference product architectures for Multi Technology Machine Tools (MTMT) carry high potential for saving expenses in product development. The main emphasis is on technology and system integration. A technological similarity assessment of the single processes involved forms the basis of this approach to assure potential for synergies. Monetary aspects in early stages of product development are considered. Based on the analysis a generic system model is connected with general product architectures for MTMT.The method introduced is validated by a Multi-Technology Machining Centre with two simultaneously usable workspaces integrating a milling spindle and two laser processing units. The research undertaken is part of the Cluster of Excellence “Integrative Production Technology for High-Wage Countries” and has been funded by German Research Foundation (DFG)

Femorodistal venous bypass evaluated with intravascular ultrasound

Objective:To evaluate the feasibility of intravascular ultrasound imaging during femorodistal venous bypass procedures to assess qualitative and quantitative parameters of the greater saphenous vein and to detect potential causes for (re)stenosis and/or occlusion.Methods:Intravascular ultrasound data obtained from 15 patients were reviewed and compared with angiographic data.Results:Intravascular ultrasound enabled differentiation between normal and thickened vein wall. Venous side-branches could be located. Intact valves could be differentiated from valves disrupted by valve cutting. Patent anastomoses could be distinguished from anastomoses with some degree of obstruction. Intravascular ultrasound imaging of the inflow and outflow tracts revealed obstructive lesions, not evidenced angiographically. Quantitative analysis revealed that the median normal vein wall thickness (tunica intima and tunica media) was 0.25 mm (range 0.17–0.40 mm). The distinct vein wall thickening encountered in three patients measured 0.82, 0.95 and 1.06 mm, respectively, and was associated with narrowing in two patients. In five of 15 patients intravascular ultrasound findings altered surgical management.Conclusion:Intravascular ultrasound is able to assess qualitative and quantitative parameters of the venous bypass and has the potential to influence surgical management based on morphologic and quantitative data

Chemical profile and in vivo toxicity evaluation of unripe Citrus aurantifolia essential oil

Citrus aurantifolia (Christm.) Swingle (syn. C. MEDICA var. ACIDA Brandis) (family: Rutaceae) essential oil is one of the cheapest oils found in local markets. Although, it is generally accepted as non-toxic to vital organs and cells, majority of people are cynical about it usage. Herein, the present study reports the chemical composition and in vivo oral toxicity study of unripe C. aurantifolia essential oil found in Ghana. The toxicity of C. aurantifolia essential oil extract was investigated via oral administration using two methods: The acute toxicity single dose study (SDS) and the repeated dose method. The oil exhibited no acute toxicity but in the sub-chronic studies, the effects was dose and time-dependent. Chemical profile investigation of the oil showed 9 constituent of phytochemicals (Germacrene isomers (61.2%), Pineen (14%), Linalool dimmer (2.9%), Bornane (11%), Citral (2.9%), Anethole (1.5%), Anisole (1.1%), Safrole (0.3%) and Demitol (0.6%)). Histopathological studies revealed conditions such as necrosis, edema and inflammatory reaction in the liver, spleen and kidneys. Marginal upsurge of biochemical parameters above normal and elevated levels of lymphocytes (35.20–46.40 g/dL) demonstrated mild toxicity among the 100 mg/kg and 500 mg/kg dose groups at the sub-chronic stage. Low levels of hemoglobin (13.60 to 12.70 g/dL), MCV (34.20–24.0 fL), MCH (40.20–36.40 g/dL) along with high levels of liver enzymes confirmed the mild toxicity of the oil at sub-chronic stage. These results demonstrate that, despite consideration of lime essential oil as safe, it can have mild hematotoxic, nephrotoxic and hepatotoxic effects