How to Decrease the Immigration Backlog: Expand Representation and End Unnecessary Detention

This Note recommends federal policy reform and local implementation in order to decrease the immigration backlog and protect the rights of non-citizens in immigration proceedings. Although non-citizens hold many of the fundamental rights and freedoms enumerated in the Constitution, several core rights— including due process and the right to counsel—are not rigorously upheld in the context of immigration proceeding. By carefully regulating expanded access to representation and ending unnecessary immigration detention, the Executive Office of Immigration Review and Congress will ensure the swift administration of justice and protect non-citizens under the federal government’s jurisdiction

Comparative expression profiling and sequence characterization of ATP1A1 gene associated with heat tolerance in tropically adapted cattle

Climate change is an imminent threat to livestock production. One adaptation strategy is selection for heat tolerance. While it is established that the ATP1A1 gene and its product play an important role in the response to many stressors, there has been no attempt to characterize the sequence or to perform expression profiling of the gene in production animals. We undertook a field experiment to compare the expression profiles of ATP1A1 in heat-tolerant Vechur and Kasaragod cattle (Bos taurus indicus) with the profile of a heat-susceptible crossbreed (B. t. taurus × B. t. indicus). The cattle were exposed to heat stress while on pasture in the hot summer season. The environmental stress was quantified using the temperature humidity index (THI), while the heat tolerance of each breed was assessed using a heat tolerance coefficient (HTC). The ATP1A1 mRNA of Vechur cattle was amplified from cDNA and sequenced. The HTC varied significantly between the breeds and with time-of-day (p < 0.01). The breed–time-of-day interaction was also significant (p < 0.01). The relative expression of ATP1A1 differed between heat-tolerant and heat-susceptible breeds (p = 0.02). The expression of ATP1A1 at 08:00, 10:00 and 12:00, and the breed–time-of-day interaction, were not significant. The nucleotide sequence of Vechur ATP1A1 showed 99% homology with the B. t. taurus sequence. The protein sequence showed 98% homology with B. t. taurus cattle and with B. grunniens (yak) and 97.7% homology with Ovis aries (sheep). A molecular clock analysis revealed evidence of divergent adaptive evolution of the ATP1A1 gene favoring climate resilience in Vechur cattle. These findings further our knowledge of the relationship between the ATP1A1 gene and heat tolerance in phenotypically incongruent animals. We propose that ATP1A1 could be used in marker assisted selection (MAS) for heat tolerance

ECG Wavelet Analysis for the Detection of Gene Mutations in Patients with Brugada Syndrome

Abstract We applied wavelet transform (WT) Introduction The Brugada syndrome (BrS) is an inherited ion chanelopathy characterised by a typical electrocardiographic (ECG) pattern of J point and ST segment elevation in the right precordial leads and predisposition towards malignant ventricular arrhythmias Both depolarisation and repolarisation abnormalities contribute to the arrhythmia substrate and arrhythmia genesis in the BrS Wavelet analysis is a form of time-frequency transformation that has long been used in non-invasive electrocardiology for detection of characteristic ECG components, heart rate variability, analysis of ischaemic ST changes, ventricular repolarisation and others In this study, we hypothesised that continuous wavelet transform (WT) applied to the QRS and ST-T wave can help to identify carriers of SCN5A mutations among patients with the BrS. We analysed digital 15-lead ECGs previously recorded during positive diagnostic ajmaline test for BrS with simultaneous acquisition of the right precordial leads in both standard, as well as &quot;high&quot; electrode positions. Methods Study population and data acquisition The study population consisted of 26 patients (age 42.0±17.8 years, 13 men, 13 women, age 41.6±19.1 and 42.4±17.2, respectively, p=0.92 for men vs women) with suspected BrS who underwent diagnostic ajmaline test as part of their standard clinical management. All patients had either normal or non-diagnostic (i.e. not displaying type 1 Brugada ECG pattern) resting ECGs before the test. Details about this patient population have been partially described in previous publication

How to Decrease the Immigration Backlog: Expand Representation and End Unnecessary Detention

This Note recommends federal policy reform and local implementation in order to decrease the immigration backlog and protect the rights of non-citizens in immigration proceedings. Although non-citizens hold many of the fundamental rights and freedoms enumerated in the Constitution, several core rights— including due process and the right to counsel—are not rigorously upheld in the context of immigration proceeding. By carefully regulating expanded access to representation and ending unnecessary immigration detention, the Executive Office of Immigration Review and Congress will ensure the swift administration of justice and protect non-citizens under the federal government’s jurisdiction

Understanding the Risks of Diffusion of Cyanobacteria Toxins in Rivers, Lakes, and Potable Water

Blue-green algae, or cyanobacteria, may be prevalent in our rivers and tap water. These minuscule bacteria can grow swiftly and form blooms in warm, nutrient-rich water. Toxins produced by cyanobacteria can pollute rivers and streams and harm the liver and nervous system in humans. This review highlights the properties of 25 toxin types produced by 12 different cyanobacteria genera. The review also covered strategies for reducing and controlling cyanobacteria issues. These include using physical or chemical treatments, cutting back on fertilizer input, algal lawn scrubbers, and antagonistic microorganisms for biocontrol. Micro-, nano- and ultrafiltration techniques could be used for the removal of internal and extracellular cyanotoxins, in addition to powdered or granular activated carbon, ozonation, sedimentation, ultraviolet radiation, potassium permanganate, free chlorine, and pre-treatment oxidation techniques. The efficiency of treatment techniques for removing intracellular and extracellular cyanotoxins is also demonstrated. These approaches aim to lessen the risks of cyanobacterial blooms and associated toxins. Effective management of cyanobacteria in water systems depends on early detection and quick action. Cyanobacteria cells and their toxins can be detected using microscopy, molecular methods, chromatography, and spectroscopy. Understanding the causes of blooms and the many ways for their detection and elimination will help the management of this crucial environmental issue

Exploring the Potential of Natural Product-Based Nanomedicine for Maintaining Oral Health

Oral diseases pose a major threat to public health across the globe. Diseases such as dental caries, periodontitis, gingivitis, halitosis, and oral cancer affect people of all age groups. Moreover, unhealthy diet practices and the presence of comorbidities aggravate the problem even further. Traditional practices such as the use of miswak for oral hygiene and cloves for toothache have been used for a long time. The present review exhaustively explains the potential of natural products obtained from different sources for the prevention and treatment of dental diseases. Additionally, natural medicine has shown activity in preventing bacterial biofilm resistance and can be one of the major forerunners in the treatment of oral infections. However, in spite of the enormous potential, it is a less explored area due to many setbacks, such as unfavorable physicochemical and pharmacokinetic properties. Nanotechnology has led to many advances in the dental industry, with various applications ranging from maintenance to restoration. However, can nanotechnology help in enhancing the safety and efficacy of natural products? The present review discusses these issues in detail

Study of break-up fusion process from forward recoil range distribution measurement

540-543In the present work, the break-up fusion or incomplete fusion (ICF) process has been studied from the forward recoil range distribution measurement for 16O + 175Lu system at ≈ 96 MeV energy. The measured forward recoil range distributions are analyzed in the framework of code SRIM. The present analysis shows clearly the role of linear momentum transfer and also the break-up of projectile 16O into its fragments (12C + 4He and/or 8Be + 8Be). Any systematic trend is not observed with the target deformation parameter (β2) dependent study of ICF. It is observed that projectile structure also affects the ICF dynamics. The projectile α-Q-value is found to be a suitable parameter which explains effectively the observed projectile structure effect on ICF