The influence of lay concepts and causal theories on definitions of mental illness and social outcomes

Lay concepts and causal attribution theories enable lay people to make sense of their social situations, more specifically, their encounters with those suffering from mental disorders by providing informational frameworks and explanations upon which to interpret their circumstances. Thus, lay concepts and causal theories about mental illness play a role in beliefs and behaviors toward those individuals. The current study surveyed 113 undergraduate students to investigate relations between knowledge of mental illness as well as causal attributions and explicit stigma associated with depression and schizophrenia, such as perceived dangerousness and desire for social distance. Scores for schizophrenia and depression were significantly correlated with one another on multiple variables, which led to the development of composite variables for knowledge, causality, familiarity, perceived, dangerousness, social distance, and benevolence. Several hierarchical regressions were performed to analyze the relationships between the variables. Knowledge and causality for mental illness were significantly correlated (r(112)=.28, p= .002). Higher scores of familiarity and knowledge were both associated with lower scores of perceived dangerousness. Gender significantly predicted social distance and benevolence, such that females reported lower values on both measures. The results of this study may have important potential implications in the area of educational reform. Insight regarding perceptions of depression and schizophrenia can be utilized in informing the public about these illnesses in a way that reduces the stigma of depression and schizophrenia to facilitate social acceptance of people with mental illnesses and of them seeking treatment

Resummation of Threshold, Low- and High-Energy Expansions for Heavy-Quark Correlators

With the help of the Mellin-Barnes transform, we show how to simultaneously resum the expansion of a heavy-quark correlator around q^2=0 (low-energy), q^2= 4 m^2 (threshold, where m is the quark mass) and q^2=-\infty (high-energy) in a systematic way. We exemplify the method for the perturbative vector correlator at O(alpha_s^2) and O(alpha_s^3). We show that the coefficients, Omega(n), of the Taylor expansion of the vacuum polarization function in terms of the conformal variable \omega admit, for large n, an expansion in powers of 1/n (up to logarithms of n) that we can calculate exactly. This large-n expansion has a sign-alternating component given by the logarithms of the OPE, and a fixed-sign component given by the logarithms of the threshold expansion in the external momentum q^2.Comment: 27 pages, 8 figures. We fix typos in Eqs. (18), (27), (55) and (56). Results unchange

Proper Eighth-Order Vacuum-Polarization Function and its Contribution to the Tenth-Order Lepton g-2

This paper reports the Feynman-parametric representation of the vacuum-polarization function consisting of 105 Feynman diagrams of the eighth order, and its contribution to the gauge-invariant set called Set I(i) of the tenth-order lepton anomalous magnetic moment. Numerical evaluation of this set is carried out using FORTRAN codes generated by an automatic code generation system gencodevpN developed specifically for this purpose. The contribution of diagrams containing electron loop to the electron g-2 is 0.017 47 (11) (alpha/pi)^5. The contribution of diagrams containing muon loop is 0.000 001 67 (3) (alpha/pi)^5. The contribution of tau-lepton loop is negligible at present. The sum of all these terms is 0.017 47 (11) (alpha/pi)^5. The contribution of diagrams containing electron loop to the muon g-2 is 0.087 1 (59) (alpha/pi)^5. That of tau-lepton loop is 0.000 237 (1) (alpha/pi)^5. The total contribution to a_mu, the sum of these terms and the mass-independent term, is 0.104 8 (59) (alpha/pi)^5.Comment: 48 pages, 6 figures. References are correcte

Vaccines : A rapidly evolving technology - Are the hurdles being addressed?

AbstractVaccination usually works in infectious disease, why not in Cancer? Differences in the potency of microbial and cancer antigens, poor initiation of an immune response due to inadequate expression of tumour associated antigens, weak antigens or tolerance induction and local immune suppression were considered. There is a big difference between a therapeutic and a prophylactic vaccine.The opinion of the expert group was that an improved therapeutic efficacy can hardly be expected by further variation of types of vaccines, schedules, routes of administration and adjuvants alone. A major hurdle for developing therapeutic cancer vaccines is the need to effectively monitor the immune response and to be able to use this in an adaptive trial approach.End-points of assessment should be different from standard treatments as complete response or partial responses are usually low, unless combined with other therapies.In order to focus resources to overcome the hurdles of enhancing the therapeutic efficacy of cancer vaccines the Cancer Vaccine Clinical Trial Working Group, representing academia and the pharmaceutical and biotechnology industries has in a consensus process defined 'A clinical development paradigm for cancer vaccines and related biologics'

A systematic review on heart-rate recovery to monitor changes in training status in athletes

Heart-rate recovery (HRR) has been proposed as a marker of autonomic function and training status in athletes. The authors performed a systematic review of studies that examined HRR after training. Five cross-sectional studies and 8 studies investigating changes over time (longitudinal) met our criteria. Three out of 5 crosssectional studies observed a faster HRR in trained compared with untrained subjects, while 2 articles showed no change as a result of training. Most longitudinal studies observed a corresponding increase in HRR and power output (training status). Although confounding factors such as age, ambient temperature, and the intensity and duration of the exercise period preceding HRR make it difficult to compare these studies, the available studies indicated that HRR was related to training status. Therefore, the authors conclude that HRR has the potential to become a valuable tool to monitor changes in training status in athletes and less well-trained subjects, but more studies and better standardization are required to match this potential

The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae, an Emerging Threat to Health-Care Facilities, and the Impact of the Centers for Disease Control and Prevention Toolkit.

Carbapenem-resistant Enterobacteriaceae (CRE), a group of pathogens resistant to most antibiotics and associated with high mortality, are a rising emerging public health threat. Current approaches to infection control and prevention have not been adequate to prevent spread. An important but unproven approach is to have hospitals in a region coordinate surveillance and infection control measures. Using our Regional Healthcare Ecosystem Analyst (RHEA) simulation model and detailed Orange County, California, patient-level data on adult inpatient hospital and nursing home admissions (2011-2012), we simulated the spread of CRE throughout Orange County health-care facilities under 3 scenarios: no specific control measures, facility-level infection control efforts (uncoordinated control measures), and a coordinated regional effort. Aggressive uncoordinated and coordinated approaches were highly similar, averting 2,976 and 2,789 CRE transmission events, respectively (72.2% and 77.0% of transmission events), by year 5. With moderate control measures, coordinated regional control resulted in 21.3% more averted cases (n = 408) than did uncoordinated control at year 5. Our model suggests that without increased infection control approaches, CRE would become endemic in nearly all Orange County health-care facilities within 10 years. While implementing the interventions in the Centers for Disease Control and Prevention's CRE toolkit would not completely stop the spread of CRE, it would cut its spread substantially, by half

The large N limit of M2-branes on Lens spaces

We study the matrix model for N M2-branes wrapping a Lens space L(p,1) = S^3/Z_p. This arises from localization of the partition function of the ABJM theory, and has some novel features compared with the case of a three-sphere, including a sum over flat connections and a potential that depends non-trivially on p. We study the matrix model both numerically and analytically in the large N limit, finding that a certain family of p flat connections give an equal dominant contribution. At large N we find the same eigenvalue distribution for all p, and show that the free energy is simply 1/p times the free energy on a three-sphere, in agreement with gravity dual expectations.Comment: 28 pages, 4 figure

Steinberg modules and Donkin pairs

We prove that in positive characteristic a module with good filtration for a group of type E6 restricts to a module with good filtration for a subgroup of type F4. (Recall that a filtration of a module for a semisimple algebraic group is called good if its layers are dual Weyl modules.) Our result confirms a conjecture of Brundan for one more case. The method relies on the canonical Frobenius splittings of Mathieu. Next we settle the remaining cases, in characteristic not 2, with a computer-aided variation on the old method of Donkin.Comment: 16 pages; proof of Brundan's conjecture adde