79 research outputs found
"An effective two dimensionality" cases bring a new hope to the Kaluza-Klein[like] theories
One step towards realistic Kaluza-Klein[like] theories and a loop hole
through the Witten's "no-go theorem" is presented for cases which we call an
effective two dimensionality cases: In the equations of motion following
from the action with the linear curvature leave spin connections and zweibeins
undetermined. We present the case of a spinor in compactified on a
formally infinite disc with the zweibein which makes a disc curved on an almost
and with the spin connection field which allows on such a sphere only one
massless normalizable spinor state of a particular charge, which couples the
spinor chirally to the corresponding Kaluza-Klein gauge field. We assume no
external gauge fields. The masslessness of a spinor is achieved by the choice
of a spin connection field (which breaks parity), the zweibein and the
normalizability condition for spinor states, which guarantee a discrete
spectrum forming the complete basis. We discuss the meaning of the hole, which
manifests the noncompactness of the space.Comment: 26 pages, 1 figure, an addition which helps to clarify the
assumptions and their consequences (the discreteness of spectrum, the
massless solution of one handedness,..
On the origin of families of quarks and leptons - predictions for four families
The approach unifying all the internal degrees of freedom--proposed by one of
us--is offering a new way of understanding families of quarks and leptons: A
part of the starting Lagrange density in d(=1+13), which includes two kinds of
spin connection fields--the gauge fields of two types of Clifford algebra
objects--transforms the right handed quarks and leptons into the left handed
ones manifesting in d=1+3 the Yukawa couplings of the Standard model. We study
the influence of the way of breaking symmetries on the Yukawa couplings and
estimate properties of the fourth family--the quark masses and the mixing
matrix, investigating the possibility that the fourth family of quarks and
leptons appears at low enough energies to be observable with the new generation
of accelerators.Comment: 31 pages,revte
Construction and refinement of preference ordered decision classes
Preference learning methods are commonly used in multicriteria analysis. The working principle of these methods is similar to classical machine learning techniques. A common issue to both machine learning and preference learning methods is the difficulty of the definition of decision classes and the assignment of objects to these classes, especially for large datasets. This paper proposes two procedures permitting to automatize the construction of decision classes. It also proposes two simple refinement procedures, that rely on the 80-20 principle, permitting to map the output of the construction procedures into a manageable set of decision classes. The proposed construction procedures rely on the most elementary preference relation, namely dominance relation, which avoids the need for additional information or distance/(di)similarity functions, as with most of existing clustering methods. Furthermore, the simplicity of the 80-20 principle on which the refinement procedures are based, make them very adequate to large datasets. Proposed procedures are illustrated and validated using real-world datasets
Puzzles of Dark Matter - More Light on Dark Atoms?
Positive results of dark matter searches in experiments DAMA/NaI and
DAMA/LIBRA confronted with results of other groups can imply nontrivial
particle physics solutions for cosmological dark matter. Stable particles with
charge -2, bound with primordial helium in O-helium "atoms" (OHe), represent a
specific nuclear-interacting form of dark matter. Slowed down in the
terrestrial matter, OHe is elusive for direct methods of underground Dark
matter detection using its nuclear recoil. However, low energy binding of OHe
with sodium nuclei can lead to annual variations of energy release from OHe
radiative capture in the interval of energy 2-4 keV in DAMA/NaI and DAMA/LIBRA
experiments. At nuclear parameters, reproducing DAMA results, the energy
release predicted for detectors with chemical content other than NaI differ in
the most cases from the one in DAMA detector. Moreover there is no bound
systems of OHe with light and heavy nuclei, so that there is no radiative
capture of OHe in detectors with xenon or helium content. Due to dipole Coulomb
barrier, transitions to more energetic levels of Na+OHe system with much higher
energy release are suppressed in the correspondence with the results of DAMA
experiments. The proposed explanation inevitably leads to prediction of
abundance of anomalous Na, corresponding to the signal, observed by DAMA.Comment: Contribution to Proceedings of XIII Bled Workshop "What Comes beyond
the Standard Model?
Evaluation of the dual mTOR / PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models
We are grateful to Wyeth/Pfizer (ONC-EU-150) and to the Scottish Funding Council (SRDG HR07005) for support of this study.This study investigated the antitumour effects of two dual mTOR/PI3K inhibitors, gedatolisib (WYE-129587/PKI-587/PF-05212384) and PF-04691502 against a panel of six human patient derived ovarian cancer xenograft models. Both dual mTOR/PI3K inhibitors demonstrated antitumour activity against all xenografts tested. The compounds produced tumour stasis during the treatment period and upon cessation of treatment, tumours re-grew. In several models, there was an initial rapid reduction of tumour volume over the first week of treatment before tumour stasis. No toxicity was observed during treatment. Biomarker studies were conducted in two xenograft models; phospho-S6 (Ser235/236) expression (as a readout of mTOR activity) was reduced over the treatment period in the responding xenograft but expression increased to control (no treatment) levels on cessation of treatment. Phospho-AKT (Ser473) expression (as a readout of PI3K) was inhibited by both drugs but less markedly so than phospho-S6 expression. Initial tumour volume reduction on treatment and regrowth rate after treatment cessation was associated with phospho-S6/total S6 expression ratio. Both drugs produced apoptosis but minimally influenced markers of proliferation (Ki67, phospho-histone H3). These results indicate that mTOR/PI3K inhibition can produce broad spectrum tumour growth stasis in ovarian cancer xenograft models during continuous chronic treatment and this is associated with apoptosis.Publisher PDFPeer reviewe
Enhanced Microwave Absorption Properties of Intrinsically Core/shell Structured La0.6Sr0.4MnO3Nanoparticles
The intrinsically core/shell structured La0.6Sr0.4MnO3nanoparticles with amorphous shells and ferromagnetic cores have been prepared. The magnetic, dielectric and microwave absorption properties are investigated in the frequency range from 1 to 12 GHz. An optimal reflection loss of −41.1 dB is reached at 8.2 GHz with a matching thickness of 2.2 mm, the bandwidth with a reflection loss less than −10 dB is obtained in the 5.5–11.3 GHz range for absorber thicknesses of 1.5–2.5 mm. The excellent microwave absorption properties are a consequence of the better electromagnetic matching due to the existence of the protective amorphous shells, the ferromagnetic cores, as well as the particular core/shell microstructure. As a result, the La0.6Sr0.4MnO3nanoparticles with amorphous shells and ferromagnetic cores may become attractive candidates for the new types of electromagnetic wave absorption materials
In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
- …