Unprocessed Meat Consumption and Incident Cardiovascular Diseases in Korean Adults: The Korean Genome and Epidemiology Study (KoGES)

Meat consumption has been shown to be associated with cardiovascular disease (CVD) risk in Western societies; however, epidemiological data are limited on the Korean population. Therefore, we examined the associations between unprocessed meat consumption and CVD incidence in Korea. Data were derived from the Ansung-Ansan cohort (2001-2012), including 9370 adults (40-69 years) without CVD or cancer at baseline. Total unprocessed meat consumption was estimated as the sum of unprocessed red meat (beef, pork, and organ meat) and poultry consumption. In the fully adjusted Cox regression model, the relative risks of CVD across increasing quintiles of total unprocessed meat intake were 1.0 (reference), 0.72 (95% confidence interval (CI): 0.55, 0.95), 0.57 (95% CI: 0.42, 0.78), 0.69 (95% CI: 0.51, 0.95), and 0.69 (95% CI: 0.48, 0.97), but no significant linear trend was detected (p for trend = 0.14). Frequent poultry consumption was significantly associated with a decreased CVD risk; this association showed a dose-response relationship (p for trend = 0.04). This study showed that a moderate intake of total unprocessed meat was inversely associated with CVD risk. A significant inverse association between poultry consumption and incident CVD was observed in Korean adults, requiring further confirmation in other populations.ope

Extensive Hemorrhage after Ultrasound-guided Fine Needle Asporation Biopsy of Thtroid Nodules in a Patient with Long-term Aspirin Therapy

Ultrasound-guided fine needle aspiration biopsy (USFNA) is a very useful procedure for the diagnosis and management of thyroid diseases. It is very safe procedure and complications have been rarely reported. We experienced a case of an extensive hemorrhage after USFNA of the thyroid nodule in a patient undergoing long-term aspirin therapy. We emphasize that it is very important to obtain a patient history carefully before performing a USFNA.ope

The Effects of C. lacerata on Insulin Resistance in Type 2 Diabetes Patients

Background: Several experimental studies have suggested beneficial effects of Ceriporia lacerata on glucose metabolism. However, there has been no human study assessing the effects of C. lacerata on glucose metabolism. Therefore, we investigated whether C. lacerata improves glucose control and insulin resistance in type 2 diabetes patients. Methods: Ninety patients diagnosed with type 2 diabetes (T2DM) for more than 6 months were enrolled. Subjects were randomly divided into placebo (n = 45) or C. lacerata (n = 45) groups and then assigned to take placebo or C. lacerata capsules (500 mg/capsule) for a 12-week intervention period. Biochemical markers, including fasting glucose, 2-hour postprandial plasma glucose, and lipid profile levels, as well as insulin, c-peptide, and Hba1c, were measured. Furthermore, insulin sensitivity indices, such as HOMA-IR, HOMA-beta, and QUICKI, were assessed before and after the 12-week administration. Results: Eighty-four patients completed the study. There were no significant differences in fasting, postprandial glucose, HbA1c, or lipid parameters. HOMA-IR and QUICKI indices were improved at week 12 in the C. lacerata group, especially in subjects with HOMA-IR of 1.8 or more (p < 0.05). Fasting, postprandial c-peptide, and insulin levels decreased at week 12 in the C. lacerata group (p < 0.05). These significant differences were not observed in the placebo group. Conclusion: Twelve-week administration of C. lacerata in T2DM patients resulted in significant improvement in insulin resistance, especially in those with lower insulin sensitivity. A larger population study with a longer follow-up period and an effort to elucidate the mechanism is warranted to further assess the effects of C. lacerata on T2DM patients.ope

(A) study of the relationship between self-care compliance, perceived self-efficacy, and health locus of control in NIDDM patie

간호학교육/석사[한글] 국민경제의 성장과 생활양식의 서구화로 인해 당뇨병이 최근 폭발적으로 늘어나 근자에는 유병율이 3∼5%에 이르고 있고 당뇨병으로 인한 사망이 늘어나고 있으며 당뇨병은 만성대사성 질환으로 조절이 가능하지만 완치되지 않으므로 평생 자가간호 이행을 계속해야 하나 대다수의 환자들이 자가간호를 제대로 이행하지 않아 질병이 악화되는 경우를 많이 볼 수 있다. 이에 본 연구는 인슐린 비의존성 당뇨환자가 지각하고 있는 자기효능정도와 건강통제위, 자가간호 이행정도를 파악하고 이들 개념간의 관계를 제시하여 이를 통해 인슐린 비의존성 당뇨환자의 자가간호 이행에 영향을 주는 요인을 파악하고 환자의 자가간호 이행능력을 향상시키고 지속시키는 간호중재방안의 마련을 위한 기초자료를 제시하고자 시도한 서술적 상관관계연구이다. 연구대상은 서울시내 일개 대학부속병원 당뇨병쎈타를 통해 통원치료를 받고있는 인슐런 비의존성 당뇨환자들 중에서 임의표출한 80명이었고 구조화된 설문지를 통하여 자료를 수집하였으며 자료수집 기간은 1997년 5월 6일부터 5월31일까지였다. 본 연구에 사용된 도구는 백경신이 개발한 것을 수정 보완한 5점척도의 20문항으로 구성된 당뇨병관리 자기효능도구와 Wallston 등이 개발한 5점척도의 18문항으로 구성된 다차원건강롱제위척도, 박오장이 개발한 당뇨환자 이행행위측정도구를 사용하였다. 자료의 분석은 빈도와 백분율, 평균 표준편차, Pearson상관계수, t-test와ANOVA, 단계별 다중회귀분석을 이용하였다. 본 연구의 결과는 다음과 같다. 1, 인슐린 비의존성 당뇨환자의 자가간호 이행정도는 평균평점 54.90점(범위15-75점)으로 나왔고, 대상자가 지각하는 당뇨병관리 자기효능은 평균평점 69.84점(범위20-100점)으로 나왔으며, 건강통제위에서 내적통제위의 평균평점이24.70점(범위6-30점), 우연통제위 평균평점이 15.84점(범위6-30점), 영향력있는 타인통제위 평점이 22.60점(범위6-30점)으로 나타났다. 2. 가설 검정 제 1 가설 : "자기효능에 대한 지각이 높을수록 자가간호 이행정도가 높을 것이다." 는 지지되었다( r=.7155, p<.001). 제 2 가설 : "내적통제위점수가 높을수록 자가간호 이행정도가 높을 것이다. "는 지지되었다( r: .3532, p< .01). 제 3 가설 : "우연통제위점수가 낮을수록 자가간호 이행정도가 높을 것이다. "도 지지되었다( r: -.2852, p<.01), 제 4 가설 : "타인의존퉁제위점수가 높올수록 자가간호 이행정도가 높을 것이다. " 도 지지되었다( r: .4052, p<.001), 3. 당뇨병관리 자기효능과 관련있는 일반적 특성은 입원경험 (t=-2.06, p=.04)으로 입원경험이 있는 군이 없는 군보다 자기효능을 높게 인지하는 것으로 나타났다. 내적통제위와 관련있는 일반적 특성은 나이(F=3.77, p=.00), 질병이환기간(F=5.63, p=.00)이었고 우 연통제위와 관련있는 변수는 직업유무(t=-2.86,p=.00), 교육정도(F=9.29, p=.00), 자가혈당측정기유무(t=-2.07, p=.04), 처방된 당뇨식이열량에 대한 인지여부( t=-3.07, p=.00)였으며, 타인의존통제위와 관련있는 변수는 나이(F=5.85, p=.00), 직업유무(t=-3.07, p=.00), 현재치료방법(F=4.69, p=.01)이었다. 그리고 자가간호이행과 관련있는 일반적 특성은 입원경험(t=-2.74, p=.00), 합병증유무(t=-2,09, p=.04), 자가혈당측정기유무(t=4.23, p=.00), 처방된 당뇨식이열략에 대한 인지여부( t=2.58, p=.01)였다. 4. 자가간호 이행에 영향을 주는 요인을 단계별 다중회귀 분석한 결과 당뇨병관리 자기효능이 51,20%의 설명력을 나타냈다. 결론적으로 인슐린 비의존성 당뇨환자의 자가간호이행을 증진시키기 위해서는 자기효능의 조정이 가장 중요함을 알 수 있다. 핵심되는 말 인슐린 비의존성 당뇨병, 자기효능, 건강통제위, 자가간호이행. [영문] The purpose of this study was to examine the relationship between self-care compliance and self-efficacy and between self-care compliance and health locus of control in 80 NIDDM patients in terms of internal locus of control, chance locus of control, and powerful others locus of control. This study was a descriptive correlation study. The subjects for this study were obtained using a convenient sampling technique, and were 80 NIDDM outpatients who were enrolled in the Diabetic Center of a University Hospital in Seoul. The tool for this study was a structured questionnaire using the Diabetes Management Self-Efficacy Instrument developed by Kyung Shin Paek(1997), the Multidimension Health Locus of Control scale developed by Wallston, Wallston & Devellis(1978), and the Diabetic Patients' Behavior Compliance Scale developed by Oh Jang Park(1984). The data was collected from May 6th to 31, 1997 and The Descriptive statistics, Pearson Correlation Coefficients, t-test, ANOVA, and Stepwise Multiple Regression were utilized to analyze the data. The results were as flows: 1. Study results indicated that the mean score of self-care compliance was 54.90 (range from 15 to 75) and perceived self-efficacy was69.84(range from 20 to 100). On the locus of control scale, the mean score of internal locus of control was 24.70 and chance locus of control was 15.84, while powerful others locus of control was 22.60 out of maximum range of 6-30, respectively. 2. This study found that the subjects' self-care compliance was positively related to their perceived self-efficacy (r=,7155, p<.001), internal health locus of control (r=.3522, p<.01), and powerful others health locus of control (r=.4052, p<.001), while it was negatively related to chance health locus of control (r=-,2852, p<.01). 3. Among the independent variables, perceived self-efficacy, powerful others health locus of control and self-blood sugar test with glucometer were the explanatory variables of the subjects' self-care compliance. The self-efficacy variable explained 51.20% of the self-care compliance scores. 4. Analysis of the demographic characteristics found that the subjects' perceived self-efficacy was influenced by their experiences of the hospitalization due to their illness (t=-2.06, p<.05); that internal health locus of control was influenced by the subjects' age (F=3.77, p<.05) and the periods after diabetic diagnosis (F=5.03, p<.05), that chance locus of control was influenced by their occupational status (t=-2.86, p<.05), educational level (F=9.29, p<.05), self-blood sugar test with glucometer (t=-2.07, p<.05), and acknowledgement of prescribed calories in diabetic diet(t=5.85, 7<.05) The powerful others locus of control was influenced by the subjects' age (F=5.85, p<.05), occupational status (t=-3.07,p<.05), and control method that they used (F=4.69, p<.05). Study of the findings implied that self-efficacy was the most powerful explanatory variable of the patients' self-care compliance. Therefore, nursing interventions directed toward increasing patients' perceived self-efficacy are required.restrictio

가계의 경제적 불안과 소비행동

학위논문(석사)--서울대학교 대학원 :소비자학과,1999.Maste

Association between sugar-sweetened beverage consumption and incident hypertension in Korean adults: a prospective study

PurposeEpidemiological information on the association between sugar-sweetened beverage (SSB) consumption and the risk for hypertension (HTN) in Koreans is very limited. We tested the hypothesis that increased SSB consumption is related to a higher risk of HTN among middle-aged Korean adults in a Korean community-based cohort.MethodsFrom participants of the cohort from 2001 to 2010, we selected 5775 subjects without HTN, diabetes, cardiovascular disease, and cancer and who had no information on dietary assessment at baseline. To assess the relationship between SSB consumption and HTN, we estimated hazard ratios (HRs) and 95% confidence intervals using Cox regression analysis. In addition, stratified analysis by body mass index (BMI) was conducted.ResultsDuring the follow-up, we identified 1175 cases of incident HTN. The adjusted HR of HTN for the highest quartile of SSB consumption was 1.21 compared to the lowest quartile. Furthermore, higher consumption of SSB was significantly associated with increased incidence of HTN in subjects with BMI25kg/m(2), whereas there was no significant association among subjects with BMI<25kg/m(2).ConclusionsThe results of this study suggest that SSB consumption was associated with an increased risk of HTN, particularly among obese participants.restrictio

The association between dietary cholesterol intake and subclinical atherosclerosis in Korean adults: The Kangbuk Samsung Health Study

Background: The Scientific Report of the Dietary Guidelines Advisory Committee (2015) concluded that restriction of dietary cholesterol is unnecessary in most adults for the prevention of cardiovascular disease. Objective: We aimed to assess the risk for subclinical atherosclerosis according to coronary artery calcium score (CACS), based on dietary cholesterol intake in apparently healthy Korean adults. Methods: This was a cross-sectional study performed in 30,068 participants (mean age 40.8 years; 84.5% men) in a health screening program in Korea. The data were collected from 2001 to 2013 and analyzed in 2015. Total energy intake and dietary cholesterol intake were assessed with a food frequency questionnaire. The participants were stratified according to quartile of dietary cholesterol intake. CACS was measured by multi-detector computed tomography. Lipid profiles were measured, and the participants were divided into 6 groups according to low-density lipoprotein cholesterol (LDL-C) level: <70, 70 to 99, 100 to 129, 130 to 159, 160 to 189, and ≥190 mg/dL. Results: The presence of coronary artery calcification was defined as CACS>0. Dietary cholesterol intake did not correlate with mean value of serum LDL-C level. For both genders, the odds ratio for coronary artery calcification was not significantly greater with greater amounts of dietary cholesterol (as assessed by quartile). The risk for coronary artery calcification was not higher in subjects with LDL-C 70-129 mg/dL compared with those with LDL-C < 70 mg/dL; however, the risk was significantly greater in subjects with LDL-C ≥ 130 mg/dL compared with those with LDL-C < 70 mg/dL. Conclusions: Dietary cholesterol intake did not have an association with LDL-C level or with risk for coronary artery calcification in apparently healthy Korean adults. The results have to be translated with consideration of limitation of population-based studies.restrictio

백서 뇌허혈 모델에서 HB1.F3 신경줄기세포의 나트륨옥소 공동수송체 리포터 유전자 영상

Thesis(doctors) --서울대학교 대학원 :협동과정(종양생물학전공),2009.2.Docto

Fibroepithelial tumors diagnosed on breast core biopsy : clinical and sonographic findings which can predict phyllodes tumor

의학과/석사유방의 핵생검에서 진단된 세포충실성섬유상피병변(fibroepithelial lesion with cellular stroma)의 수술 후의 진단 결과와 엽상종양을 예측하는데 도움이 되는 임상적 혹은 영상학적 인자가 있는지를 알아보고자 하였다.초음파유도하핵생검에서 세포충실성섬유상피병변으로 진단되고 수술을 시행하여 최종병리가 확인된 55명을 대상으로 하였다. 병변의 수술 결과에 따라 엽상종양과 엽상종양이 아닌 병변의 두 부류로 나눈 후 각각의 임상과 영상소견을 후향적으로 비교, 분석하였다. 또한 의사결정 나무모형을 이용해 엽상 종양을 예측하는데 유의한 변수들을 조합하여 분석하였다.수술로 확진된 55명의 55예의 병변 중 엽상 종양은 22예(40%), 엽상종양이 아닌 예가 33예(섬유선종 30예(54.6%), 섬유낭종변화 1예(1.8%), 선증 1예(1.8%), 섬유선증증식 1예(1.8%))였다. 엽상종양 22예의 평균 크기는 32.2 ± 14.07mm (12~55mm)였고 22명의 환자들의 평균나이는 43.5 ± 11.60세(18~69세)였으며 엽상종양이 아닌 종양 33예의 평균 크기는 22.4 ± 13.64mm (12~55mm), 33명의 평균 나이는 36.5 ± 10.25세(19~62세)로 크기와 나이 모두 통계적으로 유의한 차이를 보였다(p=0.0078, p=0.0207). 초음파 소견 중에서는 틈새(cleft)가 통계적으로 유의한 차이를 보여 엽상종양에서 더 흔하게 관찰되었다(n=14 (70%)/n=6 (30%), p=0.0016).유방의 수술 전 핵생검에서 진단된 세포충실성섬유상피병변 중 병변의 크기, 환자의 나이, 초음파 소견에서 틈새의 유무를 고려하면 엽상종양을 예측할 수 있으며 틈새가 있으면서 크기가 39mm이상인 모형과 크기가 33.5mm 미만이지만 환자의 나이가 38세 이상이고 초음파 검사의 최종범주가 범주 4에 해당하는 모형이 엽상종양을 가장 잘 예측할 수 있었다.restrictio