12 research outputs found

    (A) study on the noise and reaction to noise of inpatient

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    ํ™˜๊ฒฝ๊ด€๋ฆฌํ•™๊ณผ/์„์‚ฌ[ํ•œ๊ธ€] ๋ณธ ์—ฐ๊ตฌ๋Š” ๊ตฐ ๋ณ‘์›์˜ ์†Œ์Œํ™˜๊ฒฝ์„ ํ‰๊ฐ€ํ•˜๊ณ , ์ž…์›ํ™˜์ž๊ฐ€ ์ž…์›๊ธฐ๊ฐ„ ๋™์•ˆ ๋ณ‘์‹ค์—์„œ ์ธ์ง€ํ•˜๋Š” ์†Œ์Œ์˜ ์š”์ธ ๋ฐ ์ •๋„์™€ ์ด์— ๋Œ€ํ•œ ์ƒ๋ฆฌ์ ยท์ •์„œ์  ๋ฐ˜์‘์„ ํŒŒ์•…ํ•˜์—ฌ ์ž…์›ํ™˜์ž๋“ค์—๊ฒŒ ๋ณด๋‹ค ๋‚˜์€ ๋ณ‘์›ํ™˜๊ฒฝ์„ ์ œ๊ณตํ•˜๊ธฐ ์œ„ํ•œ ๊ธฐ์ดˆ์ž๋ฃŒ๋ฅผ ๋งˆ๋ จํ•˜๊ณ ์ž ์ˆ˜ํ–‰ํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ ๋Œ€์ƒ์ž๋Š” ๊ตญ๊ตฐ 00๋ณ‘์›์— ์ž…์›ํ•ด ์žˆ๋Š” 634๋ช…์˜ ํ™˜์ž๋ฅผ ๋Œ€์ƒ์œผ๋กœ ์„ ์ •๊ธฐ์ค€์— ์˜๊ฑฐ ํ‘œ๋ณธ ์ถ”์ถœํ•˜์˜€์œผ๋ฉฐ, ์—ฐ๊ตฌ๋„๊ตฌ๋Š” ์ผ๋ฐ˜์  ํŠน์„ฑ 4๋ฌธํ•ญ, ์ž…์›๊ด€๋ จํŠน์„ฑ 12๋ฌธํ•ญ, ์†Œ์Œ์š”์ธ 23๋ฌธํ•ญ ๊ทธ๋ฆฌ๊ณ  ์†Œ์Œ๋ฐ˜์‘์—๋Š” ์ƒ๋ฆฌ์  ๋ฐ˜์‘ 17๋ฌธํ•ญ๊ณผ ์ •์„œ์  ๋ฐ˜์‘ 13๋ฌธํ•ญ์œผ๋กœ ์ด๋ฃจ์–ด์ง„ ์„ค๋ฌธ์ง€๋ฅผ ์‚ฌ์šฉํ•˜์˜€๋‹ค. ์ž๋ฃŒ์ˆ˜์ง‘ ๊ธฐ๊ฐ„์€ 1998๋…„ 12์›” 14์ผ๋ถ€ํ„ฐ 30์ผ๊นŒ์ง€ 17์ผ๊ฐ„ ์ด์—ˆ๋‹ค. ๋˜ํ•œ, ์†Œ์Œ๋„๋Š” ํ•œ๊ตญํ™˜๊ฒฝ๊ธฐ์ˆ ์—ฐ๊ตฌ์†Œ์— ์†Œ์Œ์ธก์ •์„ ์˜๋ขฐ, ์˜ค์ „, ์˜คํ›„, ์ €๋…์‹œ๊ฐ„์— ๊ฐ ๋ณ‘๋™๋ณ„๋กœ Intergrating Sound Level Meter, NL-04, RION Co., JAPAN์„ ์ด์šฉ 2๋ถ„๊ฐ„, 2ํšŒ ์ธก์ •ํ•˜์—ฌ ํ‰๊ท ์†Œ์Œ๋„๋ฅผ ๊ตฌํ•˜์˜€๋‹ค. ๋ณธ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™๋‹ค.1) ๋ณ‘์› ๋‚ด์—์„œ ๋ฐœ์ƒํ•œ ์†Œ์Œ์€ ์ €๋…์‹œ๊ฐ„์ด ํ‰๊ท  65.68ใˆ๋กœ ๊ฐ€์žฅ ๋†’์•˜์œผ๋ฉฐ, ์˜คํ›„์‹œ๊ฐ„์ด 56 .58ใˆ๋กœ ๊ฐ€์žฅ ๋‚ฎ์•˜๊ณ , ์†Œ์Œ ์š”์ธ์œผ๋กœ๋Š” ๋ƒ‰๋‚œ๋ฐฉ ๊ธฐ๊ตฌ์—์„œ ๋‚˜๋Š” ์†Œ๋ฆฌ(2.24), ๊ธฐ๊ตฌ ์šด๋ฐ˜ ์ฐจ ๋„๋Š” ์†Œ๋ฆฌ(1.91), ์ˆ˜์•ก๊ฑธ์ด ๋„๋Š” ์†Œ๋ฆฌ(1.81) ๋“ฑ์˜ ์ˆœ์œผ๋กœ ์กฐ์‚ฌ๋˜์—ˆ๋‹ค. ์ „๋ฐ˜์ ์œผ๋กœ๋Š” ์น˜๋ฃŒ ๊ธฐ๊ตฌ๋‚˜ ๋ณ‘์› ์„ค๋น„์— ์˜ํ•œ ์†Œ์Œ์„ ๊ฐ€์žฅ ์‹œ๋„๋Ÿฝ๊ฒŒ ๋Š๋ผ๋Š” ๋ฐ˜๋ฉด ๋ณ‘์›์ง์›์— ์˜ํ•œ ์†Œ์Œ์€ ๊ฐ€์žฅ ์•ฝํ•œ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. 2) ์†Œ์Œ์— ๋Œ€ํ•ด ์ธ์ง€ํ•˜๋Š” ์ •๋„๋Š” ๊ฐ€๋” ์žˆ์Œ์ด 55.3%๋กœ ๊ฐ€์žฅ ๋†’์•˜๊ณ , ์‘๋‹ตํ™˜์ž 75.4%๊ฐ€ ์†Œ์Œ์„ ์ธ์ง€ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. ๊ทธ๋ฆฌ๊ณ  ์ž…์› ๊ด€๋ จํŠน์„ฑ์— ๋”ฐ๋ผ ๊ณผ๊ฑฐ ์ž…์›๊ฒฝํ—˜์ด ์žˆ๋Š” ๋Œ€์ƒ์ž๊ฐ€ 28.5% ์ด์—ˆ์œผ๋ฉฐ, ๊ณผ๊ฑฐ ์ž…์› ๊ธฐ๊ฐ„์€ 8์ฃผ ์ด์ƒ์ด 43.2%๋กœ ์†Œ์Œ์ธ์ง€ ์ •๋„๊ฐ€ ๊ฐ€์žฅ ๋†’์•˜๋‹ค. 3) ๊ตฐ ๋ณ‘์› ์ž…์› ํ™˜์ž์˜ ์†Œ์Œ์— ๋Œ€ํ•œ ๋ฐ˜์‘์—์„œ ์ƒ๋ฆฌ์  ๋ฐ˜์‘์€ ๋ง์†Œ๋ฆฌ๋ฅผ ์•Œ์•„๋“ค์„ ์ˆ˜ ์—†๋‹ค(1.41), ๊นœ์ง ๋†€๋ž€๋‹ค(1.39), ๊ธด์žฅํ•˜๊ฒŒ ๋œ๋‹ค(1.39) ๋“ฑ์˜ ์ˆœ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ์œผ๋‚˜, ์ „๋ฐ˜์ ์ธ ์ƒ๋ฆฌ์  ๋ฐ˜์‘์€ 4์  ๊ธฐ์ค€์œผ๋กœ ๋ณผ ๋•Œ 1.26์ ์œผ๋กœ ๊ทธ๋ฆฌ ๋†’์ง€ ์•Š์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. ํ•œํŽธ, ์ •์„œ์  ๋ฐ˜์‘์œผ๋กœ๋Š” ์งœ์ฆ๋‚œ๋‹ค(2.0), ์ˆ˜๋ฉด์ด ๋ฐฉํ•ด๋œ๋‹ค(1.95), ์‹ ๊ฒฝ์ด ๊ฑฐ์Šฌ๋ฆฐ๋‹ค(1.95) ๋“ฑ์˜ ์ˆœ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. ์ „๋ฐ˜์ ์ธ ์ •์„œ์  ๋ฐ˜์‘์€ 4์  ๊ธฐ์ค€ ํ‰๊ท  1.77์ ์œผ๋กœ, ์ƒ๋ฆฌ์  ๋ฐ˜์‘๋ณด๋‹ค๋Š” ๋†’์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. 4) ๋Œ€์ƒ์ž์˜ ์ผ๋ฐ˜์  ํŠน์„ฑ์— ๋”ฐ๋ฅธ ์†Œ์Œ ์š”์ธ ์ •๋„๋Š” ํ•™๋ ฅ์— ๋”ฐ๋ผ์„œ ๋Œ€ํ•™์ด์ƒ์ธ ์ง‘๋‹จ์ด ์†Œ์Œ์„ ๋†’๊ฒŒ ์ธ์ง€ํ•˜์˜€์œผ๋ฉฐ(p-value<0.01), ๊ณ„๊ธ‰์— ๋”ฐ๋ผ์„œ๋Š” ์žฅ๊ต์ง‘๋‹จ์—์„œ ๋†’๊ฒŒ ์ธ์ง€ํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. ๋˜ํ•œ, ์ž…์›๊ด€๋ จํŠน์„ฑ์— ๋”ฐ๋ผ์„œ ์ž…์›๊ธฐ๊ฐ„์ด 8์ฃผ ์ด์ƒ์ธ ์ง‘๋‹จ๊ณผ ์†Œํ™”๊ธฐ ๋‚ด๊ณผ ๊ฐ€ ๊ฐ€์žฅ ๋†’์•˜๊ณ , ์†Œ์Œ ์ธ์ง€๋„๊ฐ€ ๋†’์„ ์ˆ˜๋ก, ๊ณผ๊ฑฐ ์ž…์› ๊ธฐ๊ฐ„์ด ๊ธธ์ˆ˜๋ก ๋†’์€ ๊ฒƒ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค. 5) ๋Œ€์ƒ์ž์˜ ์ผ๋ฐ˜์  ํŠน์„ฑ์— ๋”ฐ๋ฅธ ์ƒ๋ฆฌ์  ๋ฐ˜์‘์—๋Š” ์œ ์˜ํ•œ ์ฐจ์ด๊ฐ€ ์—†์—ˆ์œผ๋‚˜, ๋Œ€์ƒ์ž์˜ ์ž…์›๊ด€๋ จ ํŠน์„ฑ์— ๋”ฐ๋ฅธ ์ƒ๋ฆฌ์  ๋ฐ˜์‘์€ ์ž…์›๊ธฐ๊ฐ„์ด 8์ฃผ ์ด์ƒ์ธ ์ง‘๋‹จ์ด ๊ฐ€์žฅ ๋†’๊ฒŒ ๋‚˜ํƒ€๋‚ฌ์œผ๋ฉฐ(p-value<0.01), ์™ธ๊ณผ๊ณ„ ๋ณด๋‹ค ๋‚ด๊ณผ๊ณ„ ์ง‘๋‹จ์ด ์ƒ๋ฆฌ์  ๋ฐ˜์‘์ด ๋†’๊ฒŒ ๋‚˜ํƒ€๋‚ฌ์œผ๋ฉฐ(p-value<0.05), ์„ธ๋ถ€์ž…์›๊ณผ๋กœ๋Š” ํ‰๋ถ€์™ธ๊ณผ, ์†Œํ™”๊ธฐ๋‚ด๊ณผ, ์ˆœํ™˜๊ธฐ๋‚ด๊ณผ ๋“ฑ์˜ ์ˆœ์œผ๋กœ ๋‚˜ํƒ€๋‚ฌ๋‹ค(p-value<0.001). ๊ทธ๋ฆฌ๊ณ  ์ •์„œ์  ๋ฐ˜์‘์€ ํ•™๋ ฅ์ด ๋Œ€ํ•™์ธ ์ง‘๋‹จ์ด ๋†’๊ณ (p-value<0.01), ์ž…์›๊ธฐ๊ฐ„ 8์ฃผ์ธ ์ง‘๋‹จ(p-value<0.05), ์„ธ๋ถ€ ์ž…์›๊ณผ๋กœ๋Š” ์†Œํ™”๊ธฐ ๋‚ด๊ณผ, ์†Œ์Œ์ธ์ง€๋„๊ฐ€ ๋†’์€ ์ง‘๋‹จ์—์„œ ์ •์„œ์  ๋ฐ˜์‘์ด ๋†’๊ฒŒ ๋‚˜ํƒ€๋‚ฌ๋‹ค(p-value<0.01). 6) ๋ณธ ์—ฐ๊ตฌ๊ฒฐ๊ณผ ์ผ๋ฐ˜์ ์œผ๋กœ ์†Œ์Œ์ธ์ง€๋„๊ฐ€ ๋†’์€ ํ™˜์ž์˜ ๊ฒฝ์šฐ ์†Œ์Œ์— ๋Œ€ํ•œ ๋ฐ˜์‘(์ •์„œ์ , ์ƒ๋ฆฌ์ ) ์ •๋„๊ฐ€ ๋†’์•˜์œผ๋ฉฐ, ๋‘ ๋ฐ˜์‘๊ฐ„์—๋Š” ๋†’์€ ์ƒ๊ด€๊ด€๊ณ„๋ฅผ ๋ณด์˜€๋‹ค. 7) ์ž…์›ํ™˜์ž์˜ ์†Œ์Œ์— ๋Œ€ํ•œ ์ƒ๋ฆฌ์  ๋ฐ˜์‘์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š” ์š”์ธ์œผ๋กœ๋Š” ์ˆ˜์ˆ  ์—ฌ๋ถ€(p-value<0.05), ์†Œ์Œ์ธ์ง€๋„(p-value<0.0001), ๊ณผ๊ฑฐ ์ž…์› ๊ฒฝํ—˜(p-value<0.05), ์ž…์› ๊ธฐ๊ฐ„(p-value<0.05),์ด ์œ ์˜ํ•˜๊ฒŒ ๋‚˜ํƒ€๋‚ฌ์œผ๋ฉฐ, ์ •์„œ์  ๋ฐ˜์‘์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š” ์ฃผ์š” ๋ณ€์ธ์œผ๋กœ๋Š” ์†Œ์Œ์ธ์ง€๋„(p-value<0.0001)๊ฐ€ ๋†’๊ฒŒ ๋‚˜ํƒ€๋‚ฌ๋‹ค. ์ด์ƒ์˜ ๊ฒฐ๊ณผ๋ฅผ ๋ณผ ๋•Œ ๊ตฐ ๋ณ‘์› ํ™˜๊ฒฝ ๋‚ด ์†Œ์Œ์€ ์ผ๋ฐ˜ ๋ณ‘์›๊ณผ ์œ ์‚ฌํ•œ ์ˆ˜์ค€์ด์—ˆ์œผ๋ฉฐ, ์ •๋„๋Š” ์‹ฌํ•˜์ง€ ์•Š์•˜์ง€๋งŒ, ์ž…์›ํ™˜์ž๊ฐ€ ๊ด‘๋ฒ”์œ„ํ•˜๊ฒŒ ์ธ์ง€ํ•˜๊ณ  ์žˆ์—ˆ์œผ๋ฉฐ, ๋ƒ‰๋‚œ๋ฐฉ ๊ธฐ๊ตฌ์—์„œ ๋‚˜๋Š” ์†Œ๋ฆฌ๋ฅผ ๊ฐ€์žฅ ํฐ ์†Œ์Œ์š”์ธ์œผ๋กœ ์ธ์ง€ํ•˜๊ณ  ์žˆ์—ˆ๋‹ค. ๋˜ํ•œ ์†Œํ™”๊ธฐ๋‚ด๊ณผ, ํ‰๋ถ€์™ธ๊ณผ ๋“ฑ์—์„œ ๋†’๊ฒŒ ์ธ์ง€๋˜์–ด ์ด์— ๋Œ€ํ•œ ์†Œ์Œ๊ฐ์†Œ ๋Œ€์ฑ…์ด ๊ณ ๋ ค๋˜์–ด์•ผ ํ•œ๋‹ค. ๋˜ํ•œ ๊ฒฝํ™˜์ž์˜ ๋น„์œจ์ด ๋†’์€ ๊ตฐ ๋ณ‘์›์—์„œ๋Š” ์†Œ์Œ์š”์ธ์— ๋Œ€ํ•œ ์ธ์ง€์ •๋„๊ฐ€ ์‹ฌํ•˜์ง€ ์•Š๋‹ค๊ณ  ๊ฐ„๊ณผํ•  ๊ฒƒ์ด ์•„๋‹ˆ๋ผ, ์ด ์—ฐ๊ตฌ์˜ ๋Œ€์ƒ์—์„œ ์ œ์™ธ๋œ ๊ฑฐ๋™ ๋ถˆ๊ฐ€ํ•œ ํ™˜์ž๋“ค์—๊ฒŒ ํ™˜๊ฒฝ์š”์ธ์œผ๋กœ์„œ์˜ ์†Œ์Œ์˜ ์‹ฌ๊ฐ์„ฑ์„ ๊นจ๋‹ซ๊ณ  ๋ณด๋‹ค ๋‚˜์€ ๋ณ‘์›ํ™˜๊ฒฝ์„ ์ œ๊ณตํ•˜๋„๋ก ํ•˜๋Š” ๊ฒƒ์ด ๊ฐ„ํ˜ธ์žฅ๊ต์˜ ์ž„๋ฌด๋ผ ํ•˜๊ฒ ๋‹ค. [์˜๋ฌธ] This descriptive-correlational study was conducted to examine if there was a relationship between noise level and subjective reaction to noise of inpatient. The purpose of this study was to provide a basic data for comfort of patient hospitalized. The participants were 634 patients who were hospitalized in a korea military hospital and data was collected over a period of 17 days from the 14th of December to 30th of December, 1998. Hospital patients' subjective responses to noise were evaluated with a self-reported questionnaire. Statistical analysis of the data include percentage, t- test, ANOVA, correlation, stepwise multiple regression. The results are summarized as follows; 1) The mean score of noise level was 1.26. Among noise factors reported by the subjects, that which ranked highest was "Noise of cooling-heating equipment system"(2.24). Next were "Noise from dragging"(1.81). 2) The mean score of reaction level to noise was physiological reaction 1.26 and emotional reaction level 1.77. Among physiological reaction to noise reported by the subjects, that which ranked highest was "to disturb hearing"(1.41), "frightening"(1.39), "get tension"(1.39). Among emotional reaction to noise reported by the subject, that which ranked highest was "nervous"(2.0). Next were "to disturb sleep"(1.95), and "to irritate nerve"(1.95). 3) The relationship between perceived noise level of inpatient and reaction to noise was statistically significant(p-value<0.001). The relationship between the level of perceived-noise of inpatient and physiological reaction to noise was statistically significant(p-value<0.001). The relationship between perceived noise level of inpatient and emotional reaction to noise was statistically significant(p-value<0.001). 4) There were significant differences between physiological reaction level to noise, operation Yes or No(p-value<0.05), perception to noise(p-value<0.001), admission periods(p-value<0.05). 5) There were significant differences between emotional reaction level to noise, perception to noise(p-value<0.001).restrictio

    (A) Clinical and serological study of hemolytic diseases of newborn

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    ์˜ํ•™๊ณผ/์„์‚ฌ[ํ•œ๊ธ€] 1944๋…„ Halbrecht์— ์˜ํ•ด ํ˜ˆ์•กํ˜• ๋ถ€์ ํ•ฉ์œผ๋กœ ์ธํ•œ ์‹ ์ƒ์•„์šฉํ˜ˆ์„ฑ ์งˆํ™˜์ด ๋ณด๊ณ ๋œ ์ด๋ž˜ ๋งŽ์€ ์—ฐ๊ตฌ๊ฐ€ ๋˜์–ด์™”๋‹ค. ๋‹คํ–‰ํžˆ ์šฐ๋ฆฌ๋‚˜๋ผ์—๋Š” Rh์Œ์„ฑ์ด ๋“œ๋ฌผ์–ด Rh๋ถ€์ ํ•ฉ์œผ๋กœ ์ธํ•œ ์‹ ์ƒ์•„ ์šฉํ˜ˆ์„ฑ ์งˆํ™˜์€ ๋“œ๋ฌด๋‚˜ ABO๋ถ€์ ํ•ฉ์œผ๋กœ ์ธํ•œ ๋ฐœ๋ณ‘์€ ๋น„๊ต์  ํ”ํ•œ ์ค‘์ฆ ํ™ฉ๋‹ฌ์˜ ์›์ธ์ด ๋˜๊ณ  ์žˆ ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ํŠนํžˆ ABO ๋ถ€์ ํ•ฉ์ฆ์—์„œ๋Š” Coombs๊ฒ€์‚ฌ๊ฐ€ ์Œ์„ฑ์„ ๋ณด์ด๋Š” ๊ฒฝ์šฐ๊ฐ€ ๋งŽ์•„ ํ˜ˆ์ฒญํ•™์  ์ง„๋‹จ์ด ๋ฌธ์ œ๋˜๊ณ  ์žˆ๋‹ค. ์ด์— ์ €์ž๋Š” ์ตœ๊ทผ 5๋…„๊ฐ„ ์—ฐ์„ธ๋Œ€ํ•™๊ต ๋ถ€์†๋ณ‘์›์—์„œ ์ถœ์ƒํ•˜๊ฑฐ๋‚˜ ๋™๊ธฐ๊ฐ„์ค‘ ์›์™ธ์—์„œ ์ถœ์ƒํ•˜์—ฌ ์ž„์ƒ ๋ฐ ๊ฒ€์‚ฌ์†Œ๊ฒฌ์„ ํ† ๋Œ€๋กœ ์‹ ์ƒ์•„์šฉํ˜ˆ์„ฑ ์งˆํ™˜์œผ๋กœ ์ง„๋‹จ๋œ 70์˜ˆ๋ฅผ ๋Œ€์ƒ์œผ๋กœ ๋ฐœ์ƒ๋นˆ๋„, ํ˜ˆ์•กํ˜•, ์ถœ์‚ฐ์ˆœ์„œ์™€ ๊ฐ€์กฑ๋ ฅ, ํ™ฉ๋‹ฌ์ถœํ˜„์‹œ๊ธฐ, ํ˜ˆ์ƒ‰์†Œ์น˜ ๋ฐ ๋นŒ๋ฆฌ๋ฃจ๋นˆ์น˜, Coombs๊ฒ€์‚ฌ ์–‘์„ฑ์œจ์„ ์กฐ์‚ฌํ•˜์—ฌ ๋ถ„์„ ๊ฒ€ํ† ํ•˜์—ฌ ๋ณด์•˜์œผ๋ฉฐ ์•„์šธ๋Ÿฌ 0ํ˜• ์‚ฐ๋ชจ36์˜ˆ๋ฅผ ๋Œ€์ƒ์œผ๋กœ ๋ฉด์—ญํ•ญ์ฒด์˜ ๊ฒ€์ถœ์„ ์‹œ๋„ํ•˜์—ฌ ๋‹ค์Œ๊ณผ ๊ฐ™์€ ๊ฒฐ๊ณผ๋ฅผ ์–ป์—ˆ๋‹ค. 1. ์‹ ์ƒ์•„ ์šฉํ˜ˆ์„ฑ์งˆํ™˜ 70์˜ˆ์ค‘ ABO๋ถ€์ ํ•ฉ์ฆ์ด 57์˜ˆ, Rh๋ถ€์ ํ•ฉ์ฆ์ด 13์˜ˆ ์ด์—ˆ๋‹ค. 2. ABO๋ถ€์ ํ•ฉ์ฆ์˜ Aํ˜•๊ณผ Bํ˜•๊ฐ„์˜ ์‹ฌ๋„(Severity)์˜ ์ฐจ์ด๋Š” ์—†์—ˆ๋‹ค. 3. ABO๋ถ€์ ํ•ฉ์ฆ์€ ์ฒซ์ฉจ ์•„๊ธฐ์˜ ๊ฒฝ์šฐ๊ฐ€ 47.8%, ๋‘˜์งธ, ์…‹์งธ ์•„๊ธฐ์˜ ๊ฒฝ์šฐ๊ฐ€ 52.2%์ด์—ˆ์œผ๋ฉฐ 50.0%์—์„œ ๊ฐ€์กฑ๋ ฅ์ด ์–‘์„ฑ์ด์—ˆ๋‹ค. Rh๋ถ€์ ํ•ฉ์ฆ์€ ์ฒซ์ฉจ ์•„๊ธฐ์˜ ๊ฒฝ์šฐ๊ฐ€ 46%์ด์—ˆ์œผ๋‚˜ ์ด๋“ค ๋ชจ๋‘ ์‚ฐ๋ชจ๊ฐ€ 1ํšŒ ์ด์ƒ์˜ ์ธ๊ณต์œ ์‚ฐ ๊ฒฝํ—˜์ด ์žˆ์—ˆ๋‹ค. 4. ํ™ฉ๋‹ฌ์˜ ์ถœํ˜„์‹œ๊ธฐ๋Š” ABO ๋ถ€์ ํ•ฉ์ฆ์˜ ๊ฒฝ์šฐ์—๋Š” ์ƒํ›„ 2โˆผ3์ผ์— ๋‚˜ํƒ€๋‚œ ์˜ˆ๊ฐ€ ๊ฐ€์žฅ ๋งŽ์•˜์œผ๋ฉฐ. Rh๋ถ€์ ํ•ฉ์ฆ์€ 24์‹œ๊ฐ„ ์ด๋‚ด์— ๋‚˜ํƒ€๋‚œ ์˜ˆ๊ฐ€ ๊ฐ€์žฅ ๋งŽ์•˜๋‹ค. 5. ABO๋ถ€์ ํ•ฉ์ฆ 57์˜ˆ์ค‘ 31์˜ˆ์—์„œ 1ํšŒ ์ด์ƒ ๊ตํ•œ์ˆ˜ํ˜ˆ์„ ๋ฐ›์•˜์œผ๋ฉฐ, Rh๋ถ€์ ํ•ฉ์ฆ์˜ ๊ฒฝ์šฐ์—๋Š” 13์˜ˆ์ค‘ 3์˜ˆ๋งŒ์ด ๊ตํ™˜์ˆ˜ํ˜ˆ์„ ๋ฐ›์•˜๋‹ค. 6. AB0๋ถ€์ ํ•ฉ์ฆ๊ณผ Rh๋ถ€์ ํ•ฉ์ฆ ์‚ฌ์ด์— ์ตœ๊ณ  ๋นŒ๋ฆฌ๋ฃจ๋นˆ์น˜์˜ ๋ฒ”์œ„๋Š” ์„œ๋กœ ๋น„์ˆซํ•˜์˜€์œผ๋‚˜, ์ตœ์ € ํ˜ˆ์ƒ‰์†Œ ์น˜๋ฅผ ๋ณด์ด๋Š” ์˜ˆ(10gm/dl์ดํ•˜)๋Š” Rh๋ถ€์ ํ•ฉ์ฆ์ชฝ์ด ๋‹ค์†Œ ๋งŽ์•˜๋‹ค. 7. ์ง์ ‘ COOmbs ์–‘์„ฑ์œจ์€ ABO๋ถ€์ ํ•ฉ์ฆ์˜ ๊ฒฝ์šฐ 2.2%, Rh๋ถ€์ ํ•ฉ์ฆ์˜ ๊ฒฝ์šฐ 36.3%์ด์—ˆ๋‹ค. 8. Oํ˜• ์‚ฐ๋ชจ์˜ ํ˜ˆ์ฒญ๋‚ด ๋ฉด์—ญํ•ญ์ฒด์˜ ๊ฒ€์ถœ์œจ์€ ํ•ญ์ฒดA(Anti-A)์˜ ๊ฒฝ์šฐ 72%, ํ•ญ์ฒดB(Anti-B)์˜ ๊ฒฝ์šฐ 53%์ด์—ˆ๋‹ค. ์ด์ƒ์„ ์ข…ํ•ฉํ•˜์—ฌ ๋ณผ ๋•Œ, ํ˜ˆ์•กํ˜• ๋ถ€์ ํ•ฉ์œผ๋กœ ์ธํ•œ ์‹ ์ƒ์•„ ์šฉํ˜ˆ์„ฑ ์งˆํ™˜์€ ์šฐ๋ฆฌ๋‚˜๋ผ์—์„œ๋Š” ์ค‘์š”ํ•œ ์งˆํ™˜์œผ๋กœ ๊ฐ„์ฃผ๋˜์–ด์•ผ ํ• ๊ฒƒ์ด๋ฉฐ, ํŠนํžˆ ABO๋ถ€์ ํ•ฉ์— ์ธํ•œ ๊ฒฝ์šฐ๊ฐ€ ๋Œ€๋ถ€๋ถ„์ธ ๋ฐ”, ์ด์˜ ์กฐ๊ธฐ์ง„๋‹จ๊ณผ ์น˜๋ฃŒ๋ฅผ ์œ„ํ•˜์—ฌ๋Š” ์‚ฐ์ „๊ด€๋ฆฌ์— ํ˜ˆ์•กํ˜• ๊ฒ€์‚ฌ๋ฅผ ๋ฐ˜๋“œ์‹œ ํฌํ•จ์‹œํ‚ฌ ๊ฒƒ๊ณผ ํŠนํžˆ Oํ˜•์ด๋‚˜ Rh์Œ์„ฑ ์–ด๋จธ๋‹ˆ์˜ ๊ฒฝ์šฐ์—๋Š” ether์— ์˜ํ•œ elution๋ฒ•์„ ํฌํ•จํ•œ ์—ฌ๋Ÿฌ๊ฐ€์ง€ ํ•ญ์ฒด๊ฒ€์ƒ‰์ด ๊ฐ•๊ตฌ๋˜์–ด์•ผํ•œ๋‹ค๊ณ  ์‚ฌ๋ฃŒ๋œ๋‹ค. [์˜๋ฌธ] Hemolytic disease in newborn (HDN) due to ABO or Rh incompatibility is first reported by Halbrecht (1944) and is a serious problem in the neonate. Fortunately we have very Rh incompatible HDN, because few people are Rhneg. But HDN due to ABO incompatibility is one of the most common causes of severe hemolytic jaundice in Korea. Also the Coombs test is frequently negative in ABO incompatibility. We analyzed 70 infants who were diagnosed as HDN in Severance Hospital, Seoul, Korea from March, 1976 to February, 1981 by means of clinical and laboratory baes. We also detected the immune antibody from O type 36 pregnant women. The results are as follows : 1. ABO incompatible HDN is 57 cases(81.4%) and Rh incompatible HDN is 13 cases(18.6%). 2. There is no significant difference in severity between A group and B group in ABO incompatible HDN. 3. The first born occupy 47.8% of ABO incompatible HDN, one-half having positive family history. Forty-six percent are first born in Rh incompatible HDN but the mother had wxperienced abortion more than one time. 4. The onset of jaundice is most common at 2-3 days after birth in ABO incompatible HDN and 24 Hours in Rh incompatibles. 5. Thirty one cases received exchange transfusion more than one time in ABO incompatibles but only 3 cases received exchange transfusion in Rh incompatibles. 6. The maximum bilirubin value is similar in both types of incompatibles but the number who have minimum hemoglobin (less than 10 gm/dl) value is more in Rh incompatible. 7. Direct Cooms test positive rate is 2.2% in ABO incompatibles and 36.3% in Rh incompatibles. 8. The immune antibody is found to be 72% in anti-A and 53% in anti-B in O type pregnant women. In conclusion, severe hemolytic jaundice, due to blood type incompatibility, is one of the most serious diseases and needs proper treatment, prenatal care and prevention. So there needs to be more sensitive immunoserologic methods such as ether elution Coombs test and diagnosted application to detect the immune antibody from the mother's serum.restrictio
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