Studies on the infection of freshwater crabs by Paragonimus metacercariae in Yunxiao county, Fujian

目的调查云霄县淡水蟹种类及其感染并殖吸虫囊蚴的情况。方法选取不同地理方位为调查点,捕捉各调查点的淡水溪蟹进行分类和并殖吸虫囊蚴的检查。结果全县共调查6个乡(镇)20个村,共捕捉230只蟹,查出漳州华溪蟹(n=136)、漳浦束腰蟹(n=63)和闽溪蟹(待定种)(n=31)3种;检出感染并殖吸虫蟹15只,阳性检出率为6.6%(15/230),蟹的感染指数为0.11,对福建华溪蟹和中华束腰蟹种类及分布作了修正。结论云霄县并殖吸虫宿主淡水溪蟹有3种,蟹感染并殖吸虫呈下降趋势,但仍为中度并殖吸虫疫源地。Objective To study the distribution of freshwater crabs and their infection by Paragonimus in Yunxiao county, Fujian.Methods Freshwater crabs were collected and identified.The crabs were then dissected and examined for the presence of Paragonimus metacercariae.Results Six tons of crabs from 20 villages (Yunxiao county) were collected.Three species of crabs were found , namely Sinopotamon zhangzhouense, Somanniathelphusa zhangpuensis and Minpotamon spp.The infection rate was 6.6% (15/230) for the Paragonimus, and the index of crab infection was 0.11.Species of freshwater crabs and its geographic distribution were revised for Sinopotamon fukienense and Somanniathelphusa sinensis.Conclusion Freshwater crabs are the intermediate hosts of Paragonimus in the Yunxiao county.科技部自然资源平台项目(2005DKA21104

In vitro study of cholesterol succinyl chitosan anchored liposomes as a carrier for epirubicin

背景:多糖"锚定"脂质体在抗肿瘤药物、蛋白以及基因的传输领域有着极其重要的理论及应用价值,国外已有较多机构在进行相关的研究。目的:通过"锚定"的方式制备胆甾醇琥珀酰基壳聚糖锚定脂质体,并以表阿霉素作为模型药物,考察其对包载药物体外释放性质的影响。设计、时间及地点:体外实验,于2006-09/2008-05在天津市生物医学材料重点实验室完成。材料:以壳聚糖为原料,合成胆甾醇琥珀酰基壳聚糖,并采用胶体滴定法测定其胆甾醇基取代度。方法:采用pH梯度法制备表阿霉素脂质体,然后通过共孵育的方法合成了取代度为2.80%,5.58%和8.00%的载药胆甾醇琥珀酰基壳聚糖锚定脂质体。主要观察指标:荧光分光光度计检测药物浓度;透射电镜观察脂质体形态;亚微米粒度及电位分析仪检测脂质体的粒径大小、分布和电位;动态透析法考察包载药物表阿霉素在胆甾醇琥珀酰基壳聚糖锚定脂质体中的体外释放特征。结果:胆甾醇琥珀酰基壳聚糖锚定脂质体为规则球状形态,呈现典型的核壳结构,粒径为245.4~279.7nm,zeta电位为+21.09~+25.48mV;和载药脂质体及壳聚糖包衣脂质体相比,CHCS锚定脂质体能明显延缓表阿霉素的体外释放,在胆甾醇基取... 【英文摘要】 BACKGROUND: Polysaccharides anchored liposomes play an extremely important role in the fields of antitumor drug, protein and gene transmission. Related research is also present abroad. OBJECTIVE: To prepare cholesterol succinyl chitosan (CHCS) anchored liposomes, and to investigate the effect of CHCS anchored liposomes on the release property in vitro of loading drugs taking epirubicin as a model drug. DESIGN, TIME AND SETTING: A study in vitro was performed in the Key Laboratory of Biomedical Materials o

Can Internal Control Restrain Cost Stickiness Theoretical Analysis and Empirical Evidence from the Perspective of Information Theory

在充分梳理国内外有关成本费用粘性研究文献的基础上,建立了一个基于信息的研究框架,发现成本费用粘性来源于企业内外部信息的不对称和不完备,并由此说明内部控制能够抑制成本费用粘性。在此基础上建立计量模型,利用2007-2011年我国A股上市公司的财务数据和厦门大学研制的内部控制指数,实证检验了内部控制质量对成本费用粘性的影响。实证研究发现,内部控制质量越好的公司,成本费用粘性越低;在控制收入变动幅度或区别成本费用变动方向后,上述结果仍然稳健。进一步通过对内部控制五要素分项指数的检验,发现除风险评估指标外,其他高质量的分项指标对成本费用粘性都有显著抑制作用。On the basis of the fully combed domestic and overseas research literatures related to cost stickiness, this paper sets up a research framework based on information to conduct the study.The results show that cost stickiness is derived from dissymmetry and deficiency of corporate internal and external information, and thus it shows that internal control can inhibit cost stickiness.Then it sets up an econometric model based on this and makes use of the financial data of China's A-share listed companies during 2007-2011 and the internal control index developed by Xiamen University to empirically test the influence of internal control on cost stickiness.The results reveal that the better the quality of internal control of one company, the lower the cost stickiness will be.After controlling the range of income changes or distinguishing the direction of cost changes, the above-mentioned result is still solid.Through further test of each index of the five elements?of?internal control?respectively, it is found that except the risk assessment index, the other high quality elements of internal control all have a significant?inhibitory effect on?cost stickiness.国家自然科学基金重点项目“信息生态环境与企业内部控制有效性问题研究”(71332008); 教育部人文社科研究基金青年项目“产权保护规则与居民财产性收入研究:基于法经济学视角”(14YJCZH078); 山东省社科规划重大委托项目“金融产业优化与区域发展管理协同创新研究”的子课题“外资金融规制评价体系研究”(14AWTJ01-6