Preparation, and electrochemical performance of three-dimensional porous Sn-based Alloy Anode Materials for Lithium Ion Batteries

目前商品化的锂离子电池负极主要采用石墨材料。但是石墨负极材料的理论质量比容量（372mAh.g-1）不高，已不能满足不断出现的新的电子产品的要求。科学工作者在对炭材料不断进行改性以提高其容量的同时，也在寻找炭的替代品。Sn金属由于具有较高的理论容量和合适的充放电平台(0.4~0.6VvsLi+/Li)成为研究的重点。然而锡在嵌脱锂过程中体积发生重大的变化(360%)，充放电过程中容易脱落和坍塌，造成容量的剧烈衰减。本论文在Sn电极中引入非活性金属、改善电极集流体形貌、在电解液中加入添加剂三个方面入手，着力于提高Sn基合金电极的充放电性能，并且用电化学阻抗方法研究Sn基合金电极嵌脱锂的动力学过程...Nowadays, carbonaceous materials are key anodes for commercial lithium ion batteries, but they can not meet the needs of new electronic devices owing to its low energy density (372 mAh.g-1). Researchers are trying to modify carbon materials to improve their capacity, as well as searching for new carbon alternatives. Sn based metals become research hot for its high theoretical capacity and suitable...学位：理学硕士院系专业：化学化工学院化学系_物理化学(含化学物理)学号：2052006115199

双金属Zn-Fe金属有机框架的制备及其丙酮气敏特性研究

采用溶剂热法制备了双金属Zn-Fe金属有机框架结构(Zn-Fe MOF),利用扫描电子显微镜(SEM)、透射电子显微镜(TEM)和X射线衍射仪(XRD)对其微观形貌和晶相进行表征分析。结果表明:制备的双金属Zn-Fe MOF为纳米球结构,其直径约为150 nm。同时,制备了基于双金属Zn-Fe MOF材料的气体传感器件,研究了其对丙酮的气敏特性。测试结果表明:基于双金属Zn-Fe MOF的气体传感器对丙酮的最佳工作温度为210℃。在最佳工作温度下,对浓度为1×10-6的丙酮气体响应可达到2,响应/恢复时间分别为6 s/13 s,且具有较好的重复性和长期稳定性。最后,对基于双金属Zn-Fe MOF气体传感器的气敏机理进行了讨论。国家自然科学基金项目(51205274);;山西省人才专项项目(2016[36]);;山西省自然基金项目(2016[39]);;山西省高校科技创新研究项目(2016[37]);;山西省归国留学择优项目([2014]95);;山西省归国留学基金项目(2013-035);;山西省科技重大专项项目(20121101004);;山西省高等学校特色重点学科建设项目(晋教财[2012]45号

XBRL与会计业务流程再造研究

Xbrl与会计业务流程再造是当今会计信息化研究领域的两个热点问题,Xbrl在提高会计信息提供效率、丰富会计报告内容、减少手工会计信息输入等方面与会计业务流程再造存在内在一致性,结合Xbrl研究会计业务流程对于深化会计业务流程再造理论与实践研究有着重要的意义。本文在回顾Xbrl与会计业务流程再造相关文献的基础上,分析了Xbrl与会计业务流程再造的互动关系及其应用困境,最终提出了在会计业务流程中应用Xbrl的基本思路。教育部人文社会科学重点研究基地重大项目(06JJD630019)资

基本养老保险全国统筹面临的挑战及其应对

基本养老保险全国统筹是建设更加公正的养老保险制度的客观需要。随着人口老龄化程度的加深、跨省人口流动规模的日益扩大,基本养老保险基金出现省际间不平衡问题,这就要加快基本养老保险基金的全国统筹,推动基本养老保险制度可持续的平稳运行。但是,基本养老保险全国统筹面临着建设使命、统筹任务、收支平衡以及信息技术支撑等众多因素的挑战。这就要扎实推进养老保险制度的整合建设,加强对基本养老保险全国统筹的监管,解决养老保险基金收支不平衡问题,为基本养老保险全国统筹扫清制度障碍、筹资障碍以及技术障碍,推进基本养老保险全国统筹目标的实现。教育部哲学社会科学研究重大课题攻关项目“新时代提高保障和改善民生水平研究”(18JZD043)阶段性成

Effects of starvation on biochemical compositions and digestive enzyme activities of spotted babylon, Babylonia areolata juveniles

通过室内试验测定方斑东风螺bAbylOnIA ArEOlATA在饥饿120d过程中体内生化组成、能值及消化系统主要消化酶活力的连续变化。结果表明,随着饥饿时间延长,螺体的水分与灰分含量逐渐上升,而蛋白质、脂肪及糖原含量和能值均呈下降趋势。胃、肠道与肝胰脏中脂肪酶总活力在饥饿10d时较对照组略有上升,随后呈下降趋势;淀粉酶总活力和蛋白酶总活力均随饥饿时间延长而降低。饥饿70d时,脂肪酶、淀粉酶、蛋白酶分别降为对照的70.12%、63.66%、42.79%,脂肪酶与淀粉酶总活力在70—90d时迅速下降;各酶活力在90—120d均降至较低的水平。结果进一步显示,幼螺在饥饿前期主要消耗脂肪与糖原供能,70d后加大对贮备蛋白质的动用量,而后期(90—120d)则以利用蛋白质为主;各消化酶活性在饥饿90d前快速下降,之后呈恒定状态。饥饿时螺体含水量可作为预测其营养状态的指标。An experiment was conducted to determine the effects of starvation on biochemical compositions,energy values and activities of protease,lipase and amylase of the digestive system of Babylonia areolata juveniles during a period of 120 days.The results indicated that water and ash contents in the whole soft body increased gradually,while the contents of protein,lipid and glycogen,as well as the energy values,decreased greatly during starvation.The total lipase activity obtained from stomach,intestine and hepatopancreas was higher than that from the control when the snails were deprived for 10 days;it decreased markedly during starvation,and the total activities of amylase and protease reduced gradually with prolonged starvation period.The relative activity percentages were 70.12% and 63.66% for lipase and amylase when compared to the control after being starved for 70 days,whereas the responding value was 42.79% for protease.The activities of lipase and amylase showed a marked decrease from the 70th to the 90th day;they remained stable relatively thereafter.In conclusion,the lipid and glycogen contents were mobilized greatly during early growth period,while the protein was metabolized when the snails were starved longer than 70 days and served as the predominant energy source 90 days later.The total digestive enzyme activities of all three kinds maintained at lower level from the 90th to 120th day after a rapid decrease,and the water content could be used as an effective marker to estimate the nutrient status of the snails during starvation period.现代农业产业技术体系建设专项资金(nycytx-47);科技部农业科技成果转化(03EFN213500133

福建省流动人口门诊需求行为及影响因素分析

目的通过对福建省流动人口的门诊医疗需求、门诊医疗服务利用现状及其影响因素的分析,为提高流动人口的健康水平,促进基本公共卫生服务均等化提供参考依据。方法基于2017年全国流动人口动态监测调查数据福建省资料,利用STATA 12.0软件进行统计分析。结果 2016年5—2017年5月,福建省6 999名流动人口调查对象患病后的就诊率为61.92%(2 492/4 025),选择在本地个体诊所就诊的比例最大、为23.85%(960/4 025);相对于家庭月收入≤5 000元的人群,5 001～10 000元(P=0.011)和> 10 000元(P=0.009)的人群患病后就诊的可能性更大;新型农村合作医疗保险的参加情况为是否就诊(P <0.001)和就诊地点选择(P=0.004)的双重影响因素,而参加城镇医疗保险的流动人口可能存在过度利用的情况(P=0.030)。结论流动人口门诊医疗服务利用不充分,家庭月收入、医疗保险的参加以及受教育程度是门诊服务利用的重要制约因素。厦门大学繁荣哲学社会科学项目成果(0220–Y07200);;\n厦门市2017年流动人口动态检测项目(K8218001

Electrodeposition and Lithium Storage Performance of Amorphous Fe-P Alloy Electrodes

应用电沉积技术制备了fE-P合金电极材料。采用X射线衍射(Xrd)和扫描电子显微镜(SEM)分析了该合金材料的相结构和表面形貌。Xrd分析结果表明电沉积的fE-P合金具有非晶态结构。电化学性能测试表明:平面结构的fE-P合金电极首次放电(脱锂)容量达542MAH.g-1,首次循环的库仑效率为60%;50周循环之后放电容量为366MAH.g-1。用非原位的Xrd和SEM对电极的充放电机理进行了初步研究,结果表明,首次充电(嵌锂)过程中形成lI3P相,电极表面生成纳米棒结构铁-磷合金,它能有效缓解锂嵌入/脱出时引起的合金结构变化,抑制合金材料的体积膨胀,从而提高该合金电极的充放电效率和循环性能。The planar structural Fe-P alloy deposits were prepared by electroplating.The structure and electrochem-ical performance of the electroplated Fe-P alloys have been investigated in detail.XRD results showed that Fe-P al-loy deposit exhibits an amorphous state.Electrochemical tests showed that the Fe-P alloy composite electrodes can deliver a discharge capacity of 542mAh.g-1 in the first cycle and the coulombic efficiency of 60%.At the 50th cycle the discharge capacity was 366mAh.g-1.The Fe-P electrodes with nanorods structure obtained during cycling was beneficial in reducing the irreversible capacity of Fe-P alloy electrode at initial charge-discharge,and in relaxing the volume expansion during cycling,which improved the cycleability of Fe-P alloy electrode.They are also beneficial to diffusion of Li inset/out of materials,and improve coulombic efficiency in charge-discharge cycle.国家自然科学基金(No.20773102、20833005);国家“973计划”(No.2009CB220102);国家基础科学人才培养基金(No.J0630429)项目资

CDK5-dependent BAG3 degradation modulates synaptic protein turnover

阿尔茨海默病（AD）是严重威胁人类健康的重大神经系统疾病，AD的发生发展与衰老密切相关，目前临床治疗方法十分有限。因此迫切需要从AD致病早期入手，发现和鉴定导致AD神经功能紊乱的机制和靶点，为AD的早期防治提供基础。张杰教授及其团队从高通量磷酸化蛋白质组学入手，系统研究了CDK5在神经细胞中的磷酸化底物，鉴定出了在蛋白质量控制中发挥重要功能的BAG3蛋白是CDK5的全新底物。课题组从磷酸化蛋白质组学入手，发现和阐明了细胞周期蛋白激酶5（CDK5）通过调控BAG3在维持突触蛋白水平调控中的作用机制，及其在阿尔茨海默病（AD）发生发展中的机理。 该研究是多个团队历时8年合作完成的，香港中文大学的周熙文教授、美国匹兹堡大学的Karl Herrup教授、美国Sanford-Burnham研究所的许华曦教授、美国梅奥医学中心的卜国军教授，厦门大学医学院的文磊教授、张云武教授、赵颖俊教授、薛茂强教授，军事医学科学院的袁增强教授等都参与了该工作。 厦门大学医学院2012级博士生周杰超等为文章的第一作者，张杰教授为通讯作者。Background Synaptic protein dyshomeostasis and functional loss is an early invariant feature of Alzheimer’s disease (AD), yet the unifying etiological pathway remains largely unknown. Knowing that cyclin-dependent kinase 5 (CDK5) plays critical roles in synaptic formation and degeneration, its phosphorylation targets were re-examined in search for candidates with direct global impacts on synaptic protein dynamics, and the associated regulatory network was also analyzed. Methods Quantitative phospho-proteomics and bioinformatics analyses were performed to identify top-ranked candidates. A series of biochemical assays were used to investigate the associated regulatory signaling networks. Histological, electrochemical and behavioral assays were performed in conditional knockout, shRNA-mediated knockdown and AD-related mice models to evaluate its relevance to synaptic homeostasis and functions. Results Among candidates with known implications in synaptic modulations, BCL2-associated athanogene-3 (BAG3) ranked the highest. CDK5-mediated phosphorylation on Ser297/Ser291 (Mouse/Human) destabilized BAG3. Loss of BAG3 unleashed the selective protein degradative function of the HSP70 machinery. In neurons, this resulted in enhanced degradation of a number of glutamatergic synaptic proteins. Conditional neuronal knockout of Bag3 in vivo led to impairment of learning and memory functions. In human AD and related-mouse models, aberrant CDK5-mediated loss of BAG3 yielded similar effects on synaptic homeostasis. Detrimental effects of BAG3 loss on learning and memory functions were confirmed in these mice, and such were reversed by ectopic BAG3 re-expression. Conclusions Our results highlight that neuronal CDK5-BAG3-HSP70 signaling axis plays a critical role in modulating synaptic homeostasis. Dysregulation of the signaling pathway directly contributes to synaptic dysfunction and AD pathogenesis.This work was supported by the National Science Foundation in China (Grant: 31571055, 81522016, 81271421 to J.Z.; 81801337 to L.L; 81774377 and 81373999 to L.W.); Fundamental Research Funds for the Central Universities of China-Xiamen University (Grant: 20720150062, 20720180049 and 20720160075 to J.Z.); Fundamental Research Funds for Fujian Province University Leading Talents (Grant JAT170003 to L.L); Hong Kong Research Grants Council (HKUST12/CRF/13G, GRF660813, GRF16101315, AoE/M-05/12 to K.H.; GRF16103317, GRF16100718 and GRF16100219 to H.-M,C.); Offices of Provost, VPRG and Dean of Science, HKUST (VPRGO12SC02 to K.H.); Chinese University of Hong Kong (CUHK) Improvement on Competitiveness in Hiring New Faculty Funding Scheme (Ref. 133), CUHK Faculty Startup Fund and Alzheimer’s Association Research Fellowship (AARF-17-531566) to H.-M, C. 该研究受到了国家自然科学基金、厦门大学校长基金、福建省卫生教育联合攻关基金等的资助

Electrodeposition and Lithium Storage Performance of Amorphous Fe-P Alloy Electrodes

The planar structural Fe-P alloy deposits were prepared by electroplating. The structure and electrochemical performance of the electroplated Fe-P alloys have been investigated in detail. XRD results showed that Fe-P alloy deposit exhibits an amorphous state. Electrochemical tests showed that the Fe-P alloy composite electrodes can deliver a discharge capacity of 542 mAh.g(-1) In the first cycle and the coulombic efficiency of 60%. At the 50(th) cycle the discharge capacity was 366 mAh.g(-1). The Fe-P electrodes with nanorods structure obtained during cycling was beneficial in reducing the irreversible capacity of Fe-l? alloy electrode at initial charge-discharge, and in relaxing the volume expansion during cycling, which improved the cycleability of Fe-P alloy electrode. They are also beneficial to diffusion of Li inset/out of materials, and improve coulombic efficiency in charge-discharge cycle

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

厦门大学医学院、神经科学研究所张杰教授团队发现了抑郁症新的致病基因MEN1，并阐明了MEN1调控星形胶质细胞炎症导致抑郁发生发展的新机制，为抑郁症的诊治提供了新靶点和方向。抑郁症是严重威胁人类健康的重大神经系统疾病，危及全球30%的人口。但对其发病机制并不清楚。张杰教授团队发现，在慢性不可预测以及LPS处理的模拟抑郁小鼠模型中，多发性内分泌肿瘤蛋白(menin)在大脑中的表达显著降低，并且在星形胶质细胞中降低最明显。为了研究menin是否参与了小鼠抑郁表型的产生，研究团队制作了多种神经系统menin条件性敲除小鼠。通过对这些小鼠行为学的检测，锁定了只有在星形胶质细胞中敲除menin后，小鼠才会表现出抑郁样表型。证实了menin可能是通过调控星形胶质细胞的功能促进了抑郁的发生。 MEN1基因的突变会导致多发性内分泌肿瘤，而内分泌的紊乱和抑郁等精神疾病有着密切的联系。下丘脑-垂体-肾上腺轴（HPA轴）的功能紊乱直接参与了抑郁的产生。基于此研究团队推测MEN1的基因突变是否也会导致抑郁的发生。通过和中国医学科学院基础所的许琪教授合作，研究团队对1000多例重度抑郁患者和800多例对照人群进行了MEN1基因的外显子测序。通过测序发现MEN1的一个SNP s375804228和抑郁的发生有着显著关联。该SNP导致menin第503位的氨基酸由G突变成D。通过功能研究进一步证实该突变可以阻断menin和p65的结合，从而过度激活NF-κB-IL-1β通路，导致神经炎症的发生。 张杰，厦门大学特聘教授、博士生导师。国家优秀青年科学基金；教育部新世纪优秀人才；福建省杰出青年科学基金；厦门市五四青年奖章等获得者。2011年8月加入厦门大学医学院神经科学研究所担任教授至今。张杰博士主要从事重大神经系统疾病（老年痴呆、帕金森、抑郁症、自闭症、术后认知障碍、胶质瘤）等的发病机制和药物开发研究。至今以第一作者或者通讯作者在国际知名期刊发表研究论文21篇。其中回国独立开展研究工作以后，作为通讯作者在 Neuron，Cell Reports, PNAS, The Journal of Neuroscience, Clinical Cancer Research，Cell Death and Disease, JBC, Chemistry，Chem. Biol. Drug Des.等杂志上发表多篇研究论文。【Abstract】Astrocyte dysfunction and inflammation are associated with the pathogenesis of major depressive disorder (MDD). However, the mechanisms underlying these effects remain largely unknown. Here, we found that multiple endocrine neoplasia type 1 (Men1; protein: menin) expression is attenuated in the brain of mice exposed to CUMS (chronic unpredictable mild stress) or lipopolysaccharide. Astrocyte-specific reduction of Men1 (GcKO) led to depressive-like behaviors in mice. We observed enhanced NF-κB activation and IL-1β production with menin deficiency in astrocytes, where depressive-like behaviors in GcKO mice were restored by NF-κB inhibitor or IL-1β receptor antagonist. Importantly, we identified a SNP, rs375804228, in human MEN1, where G503D substitution is associated with a higher risk of MDD onset. G503D substitution abolished menin-p65 interactions, thereby enhancing NF-κB activation and IL-1β production. Our results reveal a distinct astroglial role for menin in regulating neuroinflammation in depression, indicating that menin may be an attractive therapeutic target in MDD.We thank Prof. Guanghui Jin (Xiamen University) and Prof. Xianxin Hua (University of Pennsylvania) for providing the Men1-floxp mice. This work was supported by the National Natural Science Foundation of China (grants 81522016, 81271421, and 31571055 to J.Z.; 81625008 and 31430048 to Q.X.; 81630026 to Z.Y.; 81771163 and U1405222 to H.X.; U1505227 to G.B.; 81472725 to W.M.), the Natural Science Foundation of Fujian Province of China (grant 2013J01147 and 2014J06019 to J.Z.), the Fundamental Research Funds for the Central Universities (grants 20720150062 and 20720180049 to J.Z.), the National Key Research and Development Program of China (2016YFC1305903), and CAMS Innovation Fund for Medical Sciences (grant 2016I2M1004 to Q.X.).研究工作得到国家自然科学基金项目（81522016、81271421、31571055）以及厦门大学校长基金等资助