普及化高等教育时代中国院校市场改革前瞻

中国即将进入普及化高等教育时代,\"面向现代化、面向世界、面向未来\",我们应当追求规模、质量、结构全方位卓越的普及化。院校市场改革是实现该远大目标的突破口与关键方式之一。文章阐释了普及化高等教育与院校市场的内涵及二者相辅相成的关系,分析了我国院校市场发展现状,辨识了我国院校市场面临的国内外新形势。面向普及化高等教育时代,我国应健全法制环境,加强政策引导,使院校依法自行合理定位;关注民办教育公共性,避免误读与偏见,鼓励民办高校发展;营造开放环境,激活声誉机制,使院校间自由竞争与合作;践行有限政府理念,运用负面清单制度,落实院校自主权;迈向全球院校市场,增进高等教育服务贸易,提升院校国际竞争力

Preparation of inorganic/polymer hybrid materials in ionic liquids

离子液体是指由有机阳离子和无机或有机阴离子构成的，在室温或者室温附近温度下呈液态的盐类。与易挥发的有机溶剂相比，离子液体具有蒸气压小、不可燃、热容大、可设计性强、热稳定性好、离子电导率高、电化学窗口宽等优点，被称为一类新型的绿色溶剂。当前离子液体已广泛应用于分离过程、电化学、催化化学、材料制备等领域，其中在材料制备方面的应用处于起步阶段，研究的范围包括离子液体中聚合物的合成、无机纳米材料的制备、天然高分子的加工等。本论文借助离子液体制备了几种无机/高分子杂化材料，取得了以下成果： 1.传统制备咪唑离子液体的方法，是用咪唑和卤代烷烃反应，当卤代烷烃沸点低时(如氯甲烷、氯乙烷等)，势必对设备要求...Ionic liquids (ILs) are liquid salts at or near room temperature, which are composed entirely of organic cation and organic or inorganic anion. Compared with traditional organic solvents, ILs are regarded as novel and green solvents owing to their advantages such as low vapor pressure, nonflammable, great heat capacity, high designable, fine thermal stability, high ionic conductivity and wide elec...学位：理学博士院系专业：材料学院材料科学与工程系_高分子化学与物理学号：2072007015345

发展我国股指期货的若干问题研究

股指期货是规避股票市场系统风险的最重要工具，也是当前我国证券市场关注的热点之一，本文分三个部分来对发展我国股指期货的若干关键问题进行研究。 第一章为“股指期货市场概述”。首先介绍了股指期货这种金融衍生工具近年来在世界各国迅猛发展的趋势；第二节介绍了股指期货交易有别于股票现货交易的一些显著特点，以及股指期货市场的规避风险和价格发现等主要功能；第三节介绍了股价指数的几种计算方法，主要有算术平均法、几何平均法和加权平均法等；最后介绍了构成标准股指期货合约的基本要素，包括标的指数、交易单位、最小变动价位、最后结算价等内容。 第二章为“股指期货的应用分析”，研究了股指期货交易的几种主要应用，如：套期...学位：工商管理硕士院系专业：管理学院工商管理教育中心_工商管理硕士(MBA)学号：X199915005

Interpretation of the 2015 guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism by the European Thyroid Association

亚临床甲状腺功能亢进症在临床中很常见,但对其危害及处理有很大的争议。欧洲甲状腺学会根据现有的临床证据,公布了内因性亚临床甲状腺功能亢进症诊治指南; 。指南强调,要确立持续性亚临床甲状腺功能亢进症的诊断,明确其病因,按照其进展为临床甲亢、发生不良心血管事件及骨质疏松风险进行危险分层,以指导临床; 处理。Endogenous subclinical hyperthyroidism (Endo SHyper) is a common form of; thyroid diseases. Currently controversy exists in the management of Endo; SHyper. Based on the existing clinical evidence, the European Thyroid; Association (ETA) published a guideline on diagnosis and treatment of; Endo SHyper in 2015. The guidelines recommend that clinicians establish; the diagnosis of persisted Endo SHyper, then clarify its etiology, and; guide treatment by the risk stratification according to the development; of overt hyperthyroidism, adverse cardiovascular events and; osteoporosis

Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1

背景与目的已有的研究证明:环状RNA是一类在哺乳动物中普遍存在的具有稳定闭合环状结构的内源性RNA分子。环状RNA; circHIPK3(circular RNA HIPK3, circHIPK3)在肝细胞癌(hepatocellular carcinoma,; HCC)中表达水平较高,促进肝癌细胞生长。但是其在非小细胞肺癌(non-small cell lung cancer,; NSCLC)中的作用及其调控机制尚无文献报道。本研究拟探讨环状RNA; circHIPK3对NSCLC细胞系NCI-H1299和NCI-H2170细胞增殖的影响,并进一步研究其调控的分子机制。方法Real-time; PCR法检测circHIPK3在NSCLC各细胞系中的表达水平。CCK-8实验和克隆形成实验检测过量表达和干扰circHIPK3对细胞增殖的影响; 。双荧光素酶报告基因实验分别检验miR-379与circHIPK3及miR-379与IGF1 mRNA的结合情况。Western; blot和ELISA检测细胞内外的IGF1蛋白表达水平。结果环状RNA; circHIPK3在6株NSCLC细胞株中均有表达,其中H1299表达最低,H2170表达最高,通过转染过表达的circHIPK3可显著促进NC; I-H1299细胞增殖,干扰circHIPK3可显著抑制NCI-H2170细胞增殖。miR-379可与circHIPK3及IGF1; mRNA直接结合。过表达circHIPK3导致IGF1表达量上调,干扰circHIPK3能够下调IGF1表达水平,转入miR-379; mimics恢复了circHIPK3稳转细胞株IGF1表达水平的上调及细胞增殖表型。结论环状RNA; circHIPK3在NSCLC细胞系NCI-H1299及NCI-H2170中可通过miR-379调控IGF1表达促进细胞增殖,环状RNA; circHIPK3可能成为非小细胞肺癌治疗的新靶点。Background and objective It has been proven that the circular RNA,; possessing a stable covalently closed continuous loop, is a type of RNA; molecule which is expressed widespread in mammals. The circular RNA; circHIPK3 is abundantly expressed in hepatocellular carcinoma (HCC) and; promotes tumourgenesis. However, a role for circHIPK3 has not been; systematically examined in non-small cell lung cancer (NSCLC). In this; study, we investigated whether circHIPK3 has an effect on cell; proliferation in the NSCLC cell lines NCI-H1299 and NCI-H2170 and the; underlying molecular mechanisms. Methods The expression of circHIPK3 was; measured by real-time PCR in NSCLC cell lines. Nuclear mass separation; experiment was used to detect the location of circHIPK3 in cells. The; gain and loss function experiments were used to examine the; proliferation of NCI-H1299 and NCI-H2170 cells by Cell Counting Kit-8; (CCK-8) and the colony formation assays. Then, circHIPK3 was cloned into; the downstream of the luciferase reporter gene which activity was; detected to verify whether miR-379 could bind with circHIPK3 or IGF1; mRNA. The protein level of IGF1 was detected by Western blot and ELISA; in circHIPK3 overexpressed/knock-down NCI-H1299 and NCI-H2170 cells.; Results CircHIPK3 was generally expressed in six kinds of NSCLC cells; lines we detected, and the expression level was highest in H2170 and; lowest in H1299. Overexpression of circHIPK3 obviously promoted; NCI-H1299 cell proliferation and knock-down of circHIPK3 inhibited; NCI-H2170 cell proliferation. In the luciferase assay, miR-379 was; observed to sequester circHIPK3 and IGF1 mRNA with potential binding; sites. Furthermore, we found that the overexpression of circHIPK3 could; increase the expression levels of IGF1 and knockdown reduced it.; Moreover, up-regulation of miR-379 rescued the phenotype induced by; overexpression of circHIPK3. Conclusion CircHIPK3 could promote cell; proliferation by a circHIPK3/miR-379 pathway in NCI-H1299 and NCI-H2170; cells and might be a potential tumor biomarker for NSCLC.国家自然科学基金项

为言论自由辩护

言论自由是人作为人所享有的最基本的权利,民主国家最基本的要求,是衡量一个国家是否为法治国家的重要指标,也是我国宪法所规定的公民享有的最基本权利。本文通过分别阐述言论自由功利主义者,绝对论者,相对论者的观点,来论证我国当前立法对言论自由的规范程度

浅析金融危机下的公诉制度

由于受金融危机的影响,大量企业倒闭、破产,失业人口激增,从而引发犯罪数量剧增。本文指出为了应对金融危机下的犯罪形势,必须完善我国的公诉制度,使之在与犯罪活动作斗争的过程中更加行之有效,在监督公安机关和法院的办案过程中更加有力,在构建和谐社会的进程中发挥其应有的作用

如何构建量刑建议权的运用规则

本文通过讨论在实践中应由谁承担量刑建议权的主体,什么时间提出量刑建议权,什么方式提出量刑建议权来构建量刑建议权的运用规则

Problems and Solutions on CSR Promotion Mechanism

2013年,在社会责任推进主体、社会责任制度建设、社会责任组织管理、社会责任信息披露、社会责任融入、社会责任绩效评价等方面,我国企业社会责任推进机制建设取得较大进展,但仍存在一些亟待理论和实践加以解决的问题。存在的问题缺乏科学的顶层设计由于宏观或微观层面上都缺乏科学的顶层设计,导致我国企业社会责任实践中存在中央高校基本业务经费专项资金项目“企业社会责任绩效评价研究”(2011221036)的阶段性成