分子对接预测H5亚型禽流感病毒的广谱中和表位

H5N1禽流感病毒已经在亚洲、欧洲和非洲广泛传播,造成了巨大损失.最近我们鉴定出一株对多种来源的H5N1代表株均有良好中和活性的、识别H5亚型血凝素(hemagglutinin,HA)的广谱单克隆抗体8H5,它对寻找克服禽流感高变性的广谱治疗性抗体、疫苗和药物具有重要价值.本研究应用分子模拟技术,采用"典范结构"方法对8H5抗体Fab片段进行结构模建,并通过能量分析、SAS值分析、"拉曼强传图"检验、profile-3D分析等理论验证,获得较为合理的8H5Fab的三维空间结构.8H5Fab与3种HA蛋白晶体结构的分子对接结果表明,8H5抗体与HA蛋白的作用模式与HA宿主来源无关,但与HA结构的亚型相似性相关.综合抗原同源比对结果,推测8H5抗体识别的广谱中和表位是由HA上的Asp68,Asn72,Glu112,Lys113,Ile114,Pro118,Ser120,Tyr137,Tyr252不连续氨基酸残基组成的构象表位.这一模型将为H5亚型禽流感病毒广谱疫苗和治疗性药物的分子设计提供依据

一种利用微波辅助合成单分散稀土掺杂上转换荧光纳米晶的方法及其产物和应用

本发明涉及一种利用微波辅助合成单分散稀土掺杂上转换荧光纳米晶的方法及其产物和应用。具体地，所述纳米晶材料具有式I所示组成，其中，X1和X2为掺杂的稀土元素，分别独立地选自下组：Yb、Er、Tm、Ho、Eu、Gd、Dy、或其组合；a＝0.1‑0.3，且b＝0.01‑0.05；并且所述纳米晶材料的粒径为8‑16nm。本发明还公开了所述纳米晶材料的制备方法和应用。由于采用特定的微波辅助合成方法，使得所得纳米晶材料兼具粒径小、单分散性高和荧光强度高的特点，从而可极大地促进上转换材料的推广应用。NaY1-a-bF4X1aX2b   I

稀土掺杂金属氧化物纳米材料及其制备方法和应用

本发明涉及稀土掺杂金属氧化物纳米材料及其制备方法和应用。具体地，所述纳米材料包含金属氧化物和掺杂于所述金属氧化物中的稀土元素，且所述金属氧化物为半导体材料，并且按所述纳米材料的总重量计，所述稀土元素的掺杂量为0.5－5wt％。本发明还公开了所述纳米材料的制备方法和应用。以所述纳米材料组成的镀层(或涂层)作为界面层应用于太阳能电池中，可实现所得太阳能电池器件理想的电学属性，并实现对近红外光子的吸收利用，从而提高太阳能电池的光电转换效率

Study on the Two-Component-Determined Circulating Immune Complexes in Hyperthyroidism

采用捕捉法 EL ISA,检测 10 8例甲亢患者的抗体 /补体类双特异性免疫复合物 (Ig- C3- TCIC)和抗体 /抗体类双特异性免疫复合物 (Ig/Ig- TCIC) .结果发现 ,甲亢患者除了 C3/Ig A- TCIC含量显著高于健康人 ,C3/Ig M- TCIC与健康人无显著性差异外 ,Ig M/C3- TCIC、Ig G/C3- TCIC、Ig A/C3-TCIC和 C3/Ig G- TCIC的含量均显著低于健康人 ;各类 Ig/Ig- TCIC含量 ,除 Ig A/Ig M- TCIC与健康人无显著差异外 ,其余均显著高于健康人 .结果表明 ,甲亢患者排除“异己”抗原的能力低下 ,而免疫调节水平紊乱 ,从而出现过高的免疫应答 .也证明甲亢患者存在整体的体液和细胞免疫紊乱Capture ELISA methods were used to detect two component determined circulating immune complexes(TCIC) of Ig C3 and Ig/Ig (Ig C3 TCIC and Ig/Ig TCIC) in 108 cases of hyperthyroidism. It was found that IgM/C3 TCIC?IgG/C3 TCIC?IgA/C3 TCIC and C3/IgG TCIC were significantly lower, although the amount of C3/IgA TCIC was significantly higher in patients with hyperthyroidism than that in healthy controls,and there was no difference of C3/IgM TCIC between them. Except for IgA/IgM TCIC, furthermore, the levels of Ig/Ig TCIC were significantly higher in the patients than in the control. These findings suggest that the patients have weak function in excluding "nonego" antigens. Moreover, there is immune response over normality in the patients because of the disorder of immuno regulation. In the meanwhile, our result indicates that there is entirely humoral and cellular disorder in patients with this disease.福建省自然科学基金重点 (C970 16 );; 教育部重点实验室访问学者基金 (990 3)资助项

Research into Striga dispersal

Parasitic flowering plants of the genus Striga cause extensive damage to cereal and legume crops in Africa, including maize and cowpea. Yield losses can be greater than 50'',. Both the extent and intensity of Striga damage appear to be increasing across the region, vet factors affecting the dispersal of Striga seeds have not been properly understood. A study, conducted by scientists of the International Institute for Tropical Agriculture (IITA) at sites of high Striga infestation, examined the roles of different potential agents in the dispersal of the seeds of Striga in order to understand and control spread of the pest. One mechanism that may account for widespread parasite seed dispersal is the transportation (and often sale) of cowpea fodder from infested fields to areas deficient in animal feed during the dry season. Depending on location, inspection of the contents of a bundle of fodder can reveal the presence of seed-bearing plants of S. hermonthica, S. aspera, S. gesnerioides and Alectra vogelii. The four species may be found either individually or collectively since a]l of these parasites can occur within a single field. Control of this means of dispersal in Africa will be very difficult since transportation of fodder will continue during times of critical need for animal feed Spread of parasite seeds by fodder can be arrested only by the localized reduction of parasite populations in fodder-producing areas The overall results of these studies indicate that man, through agricultural produce and animal movement, is the primary factor in the dispersal of Stringa spp. This spread can only be controlled through farmer education and better awareness among staff of plant quarantine services. IITA PO Box 5320. Ibadan, NIGERIAParasitic flowering plants of the genus Striga cause extensive damage to cereal and legume crops in Africa, including maize and cowpea. Yield losses can be greater than 50'',. Both the extent and intensity of Striga damage appear to be increasing..

基于水溶性聚噻吩阳极界面的钙钛矿电池制备及其性能研究

有机/无机杂化的钙钛矿太阳能电池具有低成本、高效率的优点,而且能够通过溶液加工的方法实现大面积制备,因此迅速成为新型太阳能电池领域的研究热点。其中,反向p-i-n钙钛矿电池凭借其低温溶液加工的优势更是引起人们的广泛关注。通常,反向钙钛矿电池采用PEDOT:PSS作为阳极界面,但是,由于PEDOT:PSS(功函~5.1 eV)与钙钛矿价带(~5.3 eV)之间能级的不匹配,导致基于PEDOT:PSS的钙钛矿电池开路电压偏低(0.9~1V),限制了器件性能的进一步提高。因此,针对新型高功函阳极界面材料的研究就显得至关重要。为此,我们引入水溶性聚噻吩作为阳极界面,使ITO功函提高到5.26 eV,有效抑制器件界面处的能量损失,器件的开路电压和填充因子有明显提升。同时,由于聚噻吩材料具有较高的空穴迁移率,器件对界面厚度的敏感性明显降低,界面厚度在4~50 nm之间时,器件均可以取得较好的效果

基于氧化锌改性界面的有机太阳能电池的制备及性能研究

有机太阳能电池由于轻质、柔性、低成本、可溶液加工等优点持续受到研究者的广泛关注。目前,提高器件的光电转换效率和稳定性能(寿命)仍然是有机太阳能电池的研究重点,也是目前制约其走向实际应用的关键因素。要获得高效稳定的有机太阳能电池,除了活性层材料之外,界面也将起到至关重要的作用。ZnO作为电子器件中常用的阴极界面材料,具有制备方法简单、稳定性好、光透过率高、合适的能级以及良好的电荷传输特性等特点。但是,在光伏器件中,基于溶液方法制备的ZnO界面仍存在一些问题。一方面,溶液法制备的纳米粒子ZnO表面缺陷多,成为电荷复合的中心;另一方面,电荷在纳米粒子中传输具有限域性,在粒子之间跳跃传输,传输性能存在不足,器件性能对界面的厚度敏感。此外,高性能有机太阳能电池研究主要集中在反向结构器件,而高效正向结构的有机太阳能电池有待开发研究。因此,我们开展了ZnO阴极界面掺杂改性的相关研究,通过以金属离子(Al~(3+))和有机分子(EDTA)的掺杂修饰为研究模型,有效钝化界面缺陷和提升电荷传输特性,在不同的有机太阳能电池体系中均获得了器件性能的提升,对光伏器件界面构建和掺杂改性的原理方法加深了理解,促进了相关研究发展。此外,通过改进方案合成无配体的ZnO以及采用新溶剂成膜,界面无需热退火除配体,有效避免活性层受热衰减以及溶剂侵蚀问题,构建并实现了高效的正向结构有机太阳电池

一种低密度InAs量子点的分子束外延生长方法

本发明公开了一种低密度InAs量子点的分子束外延生长方法，包括：将GaAs衬底放在样品托上，并引入进样室进行烘烤；烘烤完毕，将GaAs衬底引入制备室，并对GaAs衬底进行除气处理；将除过气的GaAs衬底引入生长室，对GaAs衬底的加热器进行升温，在有As保护的情况下对GaAs衬底进行脱氧；将GaAs衬底的加热器温度降至生长温度，生长GaAs缓冲层，并掺杂Si；生长多对GaAs/AlGaAs分布式布拉格反射镜；降低生长温度，生长低密度量子点；生长InGaAs(Sb)盖层；生长耦合量子点拓展波长；生长掺杂GaAs层；制作上下电极。利用本发明，有效改善量子点发光效率，提高了收集效率以及实现了波长的调控