Apparent Diffusion and Signal Characteristics of Intermolecular Multiple Quantum Coherence NMR

分子间多量子相干(intermolecularMultipleQuantumCoherence，iMQC)自1990年被发现以来，便引起核磁共振(NMR)研究者的极大兴趣，并在许多方面得到广泛的应用。实验与理论研究均表明iMQC是由远程偶极相互作用引起的。由于非局域化的远程偶极场具有复杂的非线性特性，与其它效应的联合作用可能导致复杂多样的现象，因此，模拟与实验研究包含远程偶极场的效应具有重要的意义。 本论文研究了CRAZED实验中在远程偶极场、分子自扩散和背景梯度场等因素影响下，核自旋体系的演化，深入考察了偶极场条件下分子的表观扩散行为，获得了iMQC在改进型CRAZED序列的第二演化期（采...Since the discovery of intermolecular multiple quantum coherences (iMQC) in 1990s, iMQC have triggered much interest in NMR research community and found many applications. The iMQC phenomena were referred to be resulted from intermolecular dipole-dipole interactions. Because the non-localized dipolar field is non-linear and complex, its joint action with other effects may result in complex phenome...学位：理学博士院系专业：物理与机电工程学院物理学系_无线电物理学号：1812005140303

Design of hysteresis loop measurement instrument

为了测量多种形态磁性材料的磁滞回线,设计了磁滞回线测量仪.该仪器的磁感应强度探测器采用双线圈反相连接的方式,磁性材料可以放于任一探测线圈中,方便更换.测试表明,该套实验仪器具有良好的性能,输出图形清晰、分辨率高.A hysteresis loop measurement instrument is designed.Its detector of magnetic induction density is composed of two coils with reverse connection.It can be used to measure various kinds of magnetic materials with different shape.Experimental results show that this device has clear output figure and high sensitivity

Compositional Quantitation and Brand Identification of Beer via NMR Approach Combined with Multivariate Statistical Analysis

利用核磁共振技术检测福建产青岛、雪花、雪津麦之初和惠泉一麦等4种不同品牌啤酒的化学组分,结合多元统计方法分析不同啤酒的主成分差异,获得麦芽糖、葡萄糖、丙氨酸、乙酸等26种主要差异组分。并结合2种重要风味物质甘氨酸、丙酮酸,定量分析这28种主要成分,获得不同类型啤酒之间的组成差异及它们对啤酒风味的影响;进而建立啤酒的Fisher判别模型,实现不同品牌啤酒的鉴别。本研究可以检测不同来源啤酒样品的差异化学成分及含量,又可为其他酒类的鉴定分类提供参考。In this study, the chemical components of four beer samples of different brands including Tsingtao, Snow, Xuejin and Huiquan were quantitatively analyzed using NMR spectroscopy, and their differential components were identified by multivariate statistical analysis. 26 differential components were obtained, including maltose, glucose, alanine and organic acids. Quantitative analysis of the 26 components plus 2 important flavoring components glycine and pyruvate acid were carried out to confirm the compositional differences between these four kinds of beer and to understand their influence on the special flavor of beer. Furthermore, Fisher classification discriminant model was successfully established for the identification of beer of different brands. This study provided a new method to detect the chemical components and their content in beer of different brands, and a useful reference for the classification of other alcoholic drinks.国家自然科学基金项目(31372546,81371639);; 福建省自然科学基金项目(2014J01247,2015Y0032);; 中央高校基本科研业务费项目(20720150018

Study on the Optical-thermal Response of Nasopharyngeal Tissue

【中文文摘】利用生物传热理论模型Pennes方程对Ar+激光辐照下生物组织的温度分布进行模拟研究;实验测定了离体猪鼻咽组织在Ar+激光(λ=488.0nm和514.5nm)辐照下不同位置的温度分布,重点研究了辐照功率密度和波长对组织中温度分布的影响。理论和实验结果表明:组织中的温度分布与组织不同深部位置、激光波长以及激光辐照功率密度有关;实验获得波长488nm和514.5nm的Ar+激光分别辐照鼻咽组织时安全光剂量分别为1.85W/cm2和1.72W/cm2。 【英文文摘】The temperature distribution in nasopharynx tissue induced under the irradiation of rgon ion laser emitting at the wavelength of 488.0 nm and 514.5 nm were simulated by Pennes bioheat transfer equation.Furthermore,the dependence of measuring position,irradiation time and irradiation energy density,as well as wavelength on the temperature distribution was studied in detail.Simulation results and experimental results show that the temperature distributions in the porcine nasopharynx tissue were significantly...国家自然科学基金资助项目(60178022);; 福建省自然科学基金重大资助项目(2002F008)

Study on the Optical-thermal Response of Nasopharyngeal Tissue

【中文文摘】利用生物传热理论模型Pennes方程对Ar+激光辐照下生物组织的温度分布进行模拟研究;实验测定了离体猪鼻咽组织在Ar+激光(λ=488.0nm和514.5nm)辐照下不同位置的温度分布,重点研究了辐照功率密度和波长对组织中温度分布的影响。理论和实验结果表明:组织中的温度分布与组织不同深部位置、激光波长以及激光辐照功率密度有关;实验获得波长488nm和514.5nm的Ar+激光分别辐照鼻咽组织时安全光剂量分别为1.85W/cm2和1.72W/cm2。 【英文文摘】The temperature distribution in nasopharynx tissue induced under the irradiation of rgon ion laser emitting at the wavelength of 488.0 nm and 514.5 nm were simulated by Pennes bioheat transfer equation.Furthermore,the dependence of measuring position,irradiation time and irradiation energy density,as well as wavelength on the temperature distribution was studied in detail.Simulation results and experimental results show that the temperature distributions in the porcine nasopharynx tissue were significantly...国家自然科学基金资助项目(60178022);; 福建省自然科学基金重大资助项目(2002F008)

Dipolar Field Effects in CRAZED and COSY Experiments

文章简单描述了高极化核自旋体系中分子间多量子相干(IMQC)有关的实验现象,详细讨论了在不同温度和不同梯度场强度下CrAzEd和COSy(gCOSy)实验中的偶极场效应,实验结果表明梯度场、偶极场、分子自扩散等各种因素都会影响IMQC信号。The relevant experiment phenomena of intermolecular multiple-quantum coherence(iMQC) in highly polarized spin systems were briefly described in this paper.Dipolar effects in CRAZED and COSY(gCOSY) experiments at different temperature,different gradient strength were also discussed in detail.Experimental results suggest that factors including gradient,dipolar field,and molecular diffusion can affect iMQC signal.中央高校基本科研业务费项目(2010121010

LabVIEW在近代物理实验新课程体系构建中的应用与实践

本文在大学物理实验教学中引入模块化开放式的教学方式,导入LabVIEW虚拟仪器技术,探究LabVIEW技术在近代物理实验新课程体系建构中的应用与实践[1].教学实践表明:这种教学模式,不仅使学生对抽象的理论知识有了更加直观的认识,而且激发了学生学习的积极性,拓宽了学生的视野.同时将虚拟仪器技术与网络技术相结合,实现了开放式教学,为学生创新能力培养提供了有利的技术平台,获得了良好的教学效果.福建省自然科学基金项目资助(2014J01247

The Application of Metabolomics for Gestational Diabetes Mellitus

妊娠期糖尿病(gdM)易造成子痫前期、羊水过多、巨大儿等多种并发症。目前在妊娠中晚期检测血糖筛查gdM,确诊患者接受治疗的时间短,母婴健康存在严重隐患。代谢组学(METAbOlOMICS)是一种定量考察生命系统受内外界刺激或基因修饰后的代谢应答规律的学科。将代谢组学的方法应用于gdM研究,有望实现gdM的早期诊断,理解gdM的致病机制,对gdM的防治和母婴预后都有重要的意义。综述代谢组学方法在gdM及相关疾病研究中的应用。Gestational diabetes mellitus(GDM) easily lead to some complications,such as preeclampsia,polyhydramnios,macrosomia,and so on.The traditional diagnostic protocols for GDM mainly rely on detecting elevated glucose levels in blood,often late in the second trimester.Therefore the treatment time for the patients is not enough and the serious risk to maternal and child health raise.Metabolomics is an approach that investigates the metabolic responses of living systems to internal or external stimuli or genetic modification.The application of metabolomics to GDM research will help to interpret the pathogenesis of GDM.In addition,it can also provide the theoretical and experimental support for prevention and treatment of GDM as well as the prognosis of mothers and their infants.The characteristics of the common detection methods and the metabolomics studies of GDM were analyzed and compared in detail in this paper,and the metabolomic studies in GDM was further reviewed.国家自然科学基金(81201143;81371639); 中央高校基本科研业务费(2013121007

基于~1H-NMR的中西药干预Wilson病铜负荷大鼠肝损伤代谢组学研究

目的从代谢组学角度探讨中西药对Wilson病(WD)铜负荷大鼠模型肝损伤代谢网络的干预机制。方法 105只大鼠按照随机数字表分为7组,每组15只,分别为对照组、模型组、肝豆灵组、青霉胺组、谷胱甘肽组、SB203580组、SB203580肝豆灵组,按照文献方法复制Wilson病铜负荷大鼠模型,共计12周。从第7周开始,各干预组予以等效剂量相应药物,对照组和模型组予以等容量生理盐水灌胃,直至模型复制结束。采用~1H-NMR代谢组学技术结合多元统计方法,阐述Wilson病肝损伤的肝脏代谢轮廓变化及分析不同治法对其生物标志物的干预作用。结果 WD铜负荷大鼠模型肝脏发生明显纤维化改变,不同方法干预后肝纤维化可不同程度减轻。WD铜负荷大鼠模型肝脏酮体代谢含量升高,肌酸含量下降;青霉胺干预后,谷胱甘肽、天冬氨酸盐、肌酸、氨基酸、缬氨酸、酪氨酸、组氨酸、嘧啶、嘌呤含量上升;SB203580肝豆灵组,肌酸上升,甲胺下降;谷胱甘肽及SB203580组,谷胱甘肽、缬氨酸、组氨酸、嘧啶、嘌呤含量上升。结论中西医不同干预方法影响WD铜负荷大鼠肝脏组织谷胱甘肽、肌酸、酮体、氨基酸、嘧啶、嘌呤代谢,并有调节以上小分子物质代谢紊乱的作用,进而对WD铜负荷大鼠肝损伤有一定的修复作用。国家自然科学基金面上项目(No.81774299)安徽省自然科学基金面上项目(No.170805MH199)~

Construct new experimental curriculum system for modern physics experiment-reform and practice

探讨近代物理实验新课程体系的改革与实践,运用“分门别类、统筹兼顾“的方法,模块化实验内容,采用开放式教学模式,构建以物理专业人才的基础知识、实验能力和科研素质培养为目标的模块化近代物理实验课程新体系.The reform and practice of constructing new experimental curriculum system for modern physics experiment is discussed in this paper.In the new curriculum system,experiment content is modularized,and the opening experimental teaching mode is adopted at the same time by using the method of "categorization and overall consideration".Furthermore,the cultivation of basis knowledge,experimental skills and scientific research abilities for physical professionals are taken into account in the construction of this new modular curriculum system for modern physics experiment