Gonad shafting hormone level quantitative analysis and clinical significance for the patients with premenopausal breast disease

目的:研究绝经前(滤泡期或称卵泡前期)的女性乳腺增生和乳腺癌患者HPO轴系激素表达,包括激素雌二醇(E2)、促卵泡激素(FSH)、促黄体激素(LH)、孕酮(P)、睾酮(T)和促催乳素(PRL)6种,为乳腺增生和乳腺癌提供诊断依据。方法:采用放射免疫法检测正常人、乳腺增生和乳腺癌患者各62例血浆E2、FSH、P、T和PRL水平(E2、P和T单位为μg/L,FSH和LH单位为I U/L,PRL单位为g/L),并应用逻辑回归与判别分析等方法进行统计分析。结果:乳腺癌、乳腺增生症和正常人3组人群的激素分布不同,乳腺癌患者的E2(192.59)、FSH水平增高(24.25),LH(30.235 3)与E2、FSH存在协同性增高,Logistic回归分析和聚类分析发现,T水平乳腺癌组低于乳腺增生与正常人群组,差异有统计学意义,P<0.05。P和PRL水平越高,患乳腺癌的危险度上升。结论:通过回归分析和聚类分析,可能提高临床应用性激素检测判别疾病的能力及危险度预测,判别准确率为91.2%。OBJECTIVE: To investigate the HPO shafting including E2,FSH,LH,P,T and PRL in the mammary gland hyperplasia and breast cancer of premenopausal(follicle period or prophase) female patients,and provide bases for mammary gland hyperplasia and breast cancer diagnosis.METHODS: By the radiative immune method,the blood levels of E2,FSH,LH,P,T and PRL(the unit of E2,P and T was μg/L,the unit of FSH and LH was IU/L,and the unit of PRL was g/L) were detected in 62 normal persons,62 patients with mammary gland hyperplasia and 62 patients with breast cancer.Logistic regression analysis and discriminance methods were used for the identification of the results.RESULTS: The hormone distributions in the mammary gland hyperplasia patients,breast cancer patients and normal people were diffrerent.By logical regression analysis and discriminance methods,the levels of E2(192.59) and FSH(24.25) in the breast cancer group increased,while LH(30.235 3) increased cooperativly with the increase of E2 and FSH.The level of T hormone in the breast cancer group was significantly lower than that in the mammary gland hyperplasia group and the normal people group,P<0.05.The higher of P and PRL levels were,the higher the breast cancer risk was.CONCLUSION:The use of logistic regression and distinguish analysis are favorable methods in the diagnosis of mammary gland hyperplasia and breast cancer.The total accuracy is 91.2%.厦门市科技社会发展计划基金(3502Z20044003

浅议加强行政事业单位内部控制的对策

行政事业单位的业务范围不断扩大,其面临的监管力度也在加大,加强行政事业单位内部控制,维护财产安全,提高经济效益,对行政事业单位具有重要的现实意义。针对目前行政事业单位内部控制存在的问题,本文提出通过采取强化过程管理、建立健全内部控制制度、加强内部控制执行力和监督力等措施,建立并有效运行一套系统化、规范化的内控管理机制,以提高风险防范能力的对策建议

浅析事业单位资金管理的关键环节

无论何种单位性质,资金管理都是财务管理的基础工作,而确保资金安全并高效使用,更是保障财务工作顺利进行的先决条件。目前,我国事业单位资金筹集渠道趋向多元化、复杂化,资金管理就尤为重要。因此,加强资金管理,确保资金安全,已成为事业单位亟待解决的一项主要问题。本文以事业单位为视角,从预算管理、制度建设及内控、审核等方面阐述资金管理关键环节