Preliminary pharmacodynamic study of STS as an adjuvant ofthe chemotherapy drugs in Vitro and in Vivo

目的：研究硫代硫酸钠（STS）是否能在体内、外作为化疗药的辅药。方法：应用MTT法研究STS分别与AdM、MMC和CddP等6种抗癌单药合用时对bEl-7402和MgC80-3细胞的细胞毒性作用；应用小鼠肝癌腹水瘤（H22）模型判断STS与AdM等3种药合用时的抗癌疗效；20例人原发性肝癌病人肝动脉插管化疗（AdM、MMC和CddP）前30MIn静脉推注STS（125~25g/M2）考察STS作为化疗药辅药的作用。结果：除了CddP以外，STS（500μg/Ml）与AdM等5种抗癌单药合用时对抗癌药的抗肿瘤细胞活性无明显影响（P＞005）。当不同剂量STS（350Mg/kg、35Mg/kg）分别与AdM（6Mg/kg）、MMC（14Mg/kg）和CddP（45Mg/kg）合用或仅这3种化疗药合用时，这3组腹水瘤小鼠的存活期比对照组者显著延长（P＜0001），但3组之间无明显区别（P＞005）。人肝癌肝动脉插管化疗时，STS与AdM、MMC和CddP抗癌药合用，肝癌治疗总有效率达60%，且可减少70%病人的恶心、呕吐等副作用。结论：在体内，低浓度的STS（125~25g/M2）可与AdM，MM？Objective: To study whether sodium thiosulfate (STS) can be used as an adjuvant of the chemotherapy drugs. Methods: The cytotoxicity of STS combined with ADM, MMC, CDDP, 5Fu, MTX and VCR (1PPC/ml) respectively on the cells of BEL7402 and MGc803 was studied by MTT test in vitro.The ascitic hepatoma (H22) in mice were adopted to determine the anticancer effect of STS adjuvant of ADMMMC and CDDP.Being treated with STS(12525 g/m2) 30 min before drug administration,20 patients of hepatocellular carcinoma (HCC) were carried on transcatheter arterial chemoembolization with ADMMMC and CDDP to observe the adjuvant effect of STS. Results: The anticancer activity of ADM and the other agents respectively adjuvant with STS (500 g/ml) were not obviously influented (P >005), but that for CDDP was influented .It was proven that the survival time of ascitic hepatoma treated with ADM (6 mg/kg),MMC (14 mg/kg) and CDDP (45 mg/kg) alone or three drugs in addition to STS (350 mg/kg,35 mg/kg) respectively was not significantly different (P >005).The survival time of each groups was significantly longer than that of control group (P< 0001).It have also been proven that STS adjuvant of ADM, MMC and CDDP was not decreased the chemotherapry effect (RR=60%) by transcatheter arterial chemoembolization in HCC, simultaneously it alleviated the nausea and vomiting in 70%patients. Conclusion: The study provides evidence that in vivo, STS (12525 g/m2) can be used as an adjuvant of chemotherapy drugs,such as ADM,MMC, including CDDP, and so on , for decreasing nausea and vomiting effects, espacially for transcatheter chemotherapy .福建省“八五”肝癌攻关课

Action recognition based on the angle histogram of key parts

当前的姿态表示的行为识别方法通常对姿态的准确性做了很强的假设,而当姿态分析不精确时,这些现有方法的识别效果不佳。提出了一种低维的、鲁棒的基于关键肢体角度直方图的人体姿态特征描述子,用于将整个动作视频映射成一个特征向量。同时,还在特征向量中引入共生模型,用以表示肢体间的关联性。最后,设计了分层的SVM分类器,第1层主要用于选择高判别力的肢体作为关键肢体,第2层则利用关键肢体的角度直方图并作为特征向量,进行行为识别。实验结果表明,基于关键肢体角度直方图的动作特征具有较好的判别能力,能更好地区分相似动作,并最终取得了更好的识别效果。The current pose-based methods usually make a strong assumption for the accuracy of pose,but when the pose analysis is not precise,these methods cannot achieve satisfying results of recognition.Therefore,this paper proposed a low-dimensional and robust descriptor on the gesture feature of the human body based on the angle histogram of key limbs,which is used to map the entire action video into an feature vector.A co-occurrence model is introduced into the feature vector for expressing the relationship among limbs.Finally,a two-layer support vector machine( SVM) classifier is designed.The first layer is used to select highly discriminative limbs as key limbs and the second layer takes angle histogram of key limbs as the feature vector for action recognition.Experiment results demonstrated that the action feature based on angle histogram of key limbs has excellent judgment ability,may properly distinguish similar actions and achieve better recognition effect.国家自然科学基金资助项目(61202143); 福建省自然科学基金资助项目(2013J05100;2010J01345;2011J01367); 厦门市科技重点项目资助项目(3502Z20123017

Relieving EFFect of Sodium ThiosulFate on Transarterial Chemotherapic Emeses

报告硫代硫酸钠（STS）对20例肝动脉导管介入化疗病人的止呕辅助作用。通过体外琥珀酸脱氢酶抑制法（MTT）研究STS（500μg/Ml）辅助阿霉素（AdM）、丝裂霉素C（MMC）、顺铂（CddP）等7种抗癌药的抗肿瘤敏感试验，STS辅佐抗癌药的抗肿瘤活性无明显降低（P＞0·05），CddP除外。临床上，对肝癌病人经皮肝动脉插管化疗前30MIn静脉注射STS（1.25~2.50g/M2）或肌内注射灭吐灵（0.4Mg/kg）进行比较，观察两组病人呕吐的程度并进行统计分析。结果表明：STS比灭吐灵更能降低呕吐发生率而不影HCC的化疗效果。值得进一步研究STS辅佐其它化疗药的抗肿瘤作用，以及它在肿瘤化疗中的应用价值。It was reported that sodium thiosulFate (STS) was contributed to antivomiting eFFect in 20 transarterial chemotherapic patients.The antitumor sensitivity of STS (0.05 ) except For CDDP clinically,to comparing the adjuncting eFFects of STS (iv.30min ahead) or metoclopramdum (im.30min ahead) to ADM、MMC and CDDP on HCC(40 cases),the degrees of vomiting in hepatoma patient aFter transcatheter arterial chemoem bolization with ADM、MMC and CDDP were statisticaly analysed.It have been proven that STS was contributed to the low incidence of vomiting and superior to metocloe pramidum,without worsening of the chemotherapry of HCC.It is worth Futher studying adjuvant STS to other antitumor drungs and exploring potential application of chematherapy in cancer

新疆国界管理信息系统

该项目建立了新疆国界综合数据库,将与国界管理相关的地图、航空相片、卫星影像、数字地面模型、文档文献、多媒体材料等进行合理的组织和规划,以地理信息系统为基本手段,在空间数据库的基础上,集成各种数据和资料,形成一个开放式、规范化的综合性大型多尺度数据库;同时建立新疆国界管理应用系统,在建立管理对象模型的基础上,进行新疆国界地理空间数据检索查询、空间数据分析、三维虚拟平台、仿真飞行等应用系统。该系统全面提高了新疆国界管理的信息化能力以及新疆边界划界及管理的决策支持能力。该系统还结合三维虚拟现实技术,开发三维虚拟现实应用平台,用先进的展示手段使决策者对不同管理、决策方案运用的利害得失与时空过程有全面的..