NMR-based metabolomic analysis for mechanisms of both protections of HDL and apoA-I mimetic peptide D-4F, and injury of contrast media on endothelial cells

细胞代谢组学将高通量检测技术与多种数据分析方法结合，用于揭示细胞内整体、动态的代谢变化，在药物研究中发挥着重要的作用。本论文采用基于1H核磁共振（NMR）的细胞代谢组学方法，探讨与内皮细胞代谢相关的药物作用机制。 研究表明，载脂蛋白A-I（apoA-I）模拟肽D-4F展现出许多与高密度脂蛋白（HDL）相似的内皮保护功能。但是，目前并不清楚D-4F的内皮保护机制是否与HDL完全一样。因此，我们运用基于1HNMR的代谢组学方法，比较HDL和D-4F拮抗氧化型低密度脂蛋白（ox-LDL）诱导的内皮细胞紊乱的保护机制。我们发现ox-LDL不仅抑制内皮细胞的迁移，而且引发内皮细胞的代谢紊乱。这种代谢紊...Cell metabolomics is being used to reveal comprehensive and dynamic metabolic alterations in cells, which integrates high throughput detection technology and several data analysis methods. It plays a vital role in drug research. In this thesis, we conducted nuclear magnetic resonance (NMR)-based cell metabolomic analysis to elucidate the molecular mechanisms underlying the effects of drugs on endo...学位：理学硕士院系专业：化学化工学院_化学生物学学号：2052014115164

溢流管式多层气固流化床稳定操作气速范围的影响因素

在四段溢流管式多层流化床装置中研究了固体颗粒加料速率、分布板开孔率及孔径、溢流管内径、颗粒种类及粒径对多层流化床稳定操作气速范围的影响．结果表明，多层流化床最小稳定操作气速（Umin）随颗粒加料速率、分布板开孔率及颗粒粒度增大而增大，随溢流管管径增大而减小，与分布板孔径大小无关；最大稳定操作气速（Umax）随分布板开孔率和孔径及颗粒粒度增大而增大，随溢流管管径增大而减小．石英砂和煤颗粒的最大稳定操作气速均先随加料速率增加而增加，超过某一加料速率（表观颗粒速度约为1．0×10^-4m／s）后基本保持不变．在相同固体加料速率下，石英砂的最大与最小稳定操作气速比（Umax／Umin）约是煤颗粒的3倍，表明石英砂比煤颗粒具有更大的操作弹性，可能是由于使用的褐煤含水量高、流动性差所致

松木粉热解和生物油精制的实验研究

Pine sawdust with particle size of 60-100 mesh was pyrolyzed in a fluidized bed under 550℃ and flow gas volume of 3 m^3/h. The product distribution was oil phase of 18.7%, aqueous phase of 15.9%, coke of 46.2% and gas phase of 19.2%. Physical-chemical an

FAST PYROLYSIS OF PINE SAWDUST AND BIO-OIL REFINEMENT

Pine sawdust with particle size of 60-100 mesh was pyrolyzed in a fluidized bed under 550℃ and flow gas volume of 3 m^3/h. The product distribution was oil phase of 18.7%, aqueous phase of 15.9%, coke of 46.2% and gas phase of 19.2%. Physical-chemical an