农村金融供求现状调查分析

文章以农村资金需求的角度出发,分析了当前我国农村金融资金的供给现状,努力从多方面、多角度探求各种改善农村资金供给的措施,以期为农村发展提供资金支持

Chiral Separation of Rosiglitazone Sodium by Aqueous/Nonaqueous Capillary Electrophoresis

以环糊精及其衍生物为手性选择剂,通过优化缓冲液的浓度、酸度以及采用环糊精的种类和浓度等,建立了罗格列酮钠对映体的水介质和非水介质两种毛细管电泳拆分方法。最佳条件为:150 mmol/LTris-H3PO4缓冲液,pH=2.0,含有1 mmol/Lβ_CD或DM_β_CD,10%(φ)甲醇的运行液,分离电压为25 kV,检测波长215 nm。也可以使用含有9 mmol/L HDMS_β_CD,20 mmol/L磷酸和10 mmol/L NaOH的甲醇电泳液。两种拆分体系均实现了罗格列酮钠对映体的基线分离,而且拆分效率基本相当。方法简便、快速,可作为罗格列酮钠的手性分离方法。HPCE methods for separating and determining the rosiglitazone sodium enantiomers were estabˉlished.The effects of buffer concentration,pH,and the type and concentrations of CDs in the chiral separaˉtion of rosiglitazone sodium were investigated.The buffer solution used in aqueous capillary electrophoresis(ACE)was150mmol/L Tris-H 3 PO 4 solution,pH=2.0,containing1mmol/Lβ-CD or DM-β-CD,and10%(φ)methanol.The voltage applied was25kV,and the detective wavelength was215nm.In addiˉtion,a simple method for the separation of rosiglitazone sodiumenantiomers was described by nonaqueous capˉillary electrophoresis(NACE)after establishing suitable separation conditions.Under the experiment condiˉtions adopted,the baseline separation of rosiglitazone sodium enantiomers was obtained by the two methods.The proposed methods were simple,rapid and accurate,and could be used for the chiral separation of rosiglitaˉzone sodium

Chiral separation of zolmitriptan with capillary zone electrophoresis

目的:以环糊精及其衍生物为手性选择剂,通过优化缓冲液的浓度、酸度以及采用环糊精的种类和浓度以达到佐米曲坦的基线分离,并将建立方法应用于实际样品的质量控制中。方法:用20mmol·L~(-1)的磷酸二氢钾-磷酸缓冲液,pH=2.0,含有10mmol·L~(-1)羟丙基-β-环糊精(HP-β-CD)的运行液,分离电压为25kV,检测波长226nm。结果:佐米曲坦对映体的分离度达到3.1,本方法可以灵敏检出限量为0.5%的 R 构型光学异构体。结论:方法简便,快速,准确,可有效控制本品中R对映体杂质含量。Objective:To establish HPCE methods for separating and determining the zolmitriptan enantiomers and to investigate the influence of relative factors,such as buffer concentration,pH,CDs types and their concentration, on the chiral separation of zolmitriptan.Methods:The buffer solution adopted was 20 mmol·L~(-1)phosphate solu- tion,pH=2.0,with 10 mmol·L~(-1)HP-β-CD as chiral selector.Applied voltage was 25 kV,and the detection wavelength was 226 nm.Results:Under the optimum experiment conditions,the baseline separation of zolmitriptan enantiomers was obtained,with the resolution better than 3.1.Conclusion:The proposed method is simple,rapid and accurate,and can be used for the quality control of the chiral purity