Coupling of Nanoflow Liquid Chromatography and Multimode Detection

随着基因组测序计划的完成，生命科学研究领域开始步入后基因组时代。蛋白质作为基因功能的体现者和生命活动的直接执行者，开始引起了广泛的关注。当前蛋白质组学面临的巨大挑战在于如何从极微量的样品中分析鉴定丰度差异大且组成复杂的蛋白质。以纳流液相色谱、毛细管电泳为主的高效分离技术为微量样品的解析提供了更多选择。纳流液相分离极低的体积流量能显著减少溶剂消耗，减小分析成本，降低样品稀释程度，提高分析检测灵敏度，与微量样品有良好的匹配性；同时能显著能降低质谱离子源的负担，与质谱检测器有较好的兼容性。另一方面，采用将多种检测技术集成的多维检测模式，一次分离获得蛋白质组全方位信息的分析策略，将有效的提高分析效率。...Since the completion of human genome project, life science research is now entering the post-genome era. As the presenter of gene functions and physiological processes, proteins have attracted extensive concerns in this era. Currently, proteomics is facing a great challenge, which is how to analyze and identify proteins of different abundance and compositions in a trace amount sample. Nano high ...学位：理学硕士院系专业：化学化工学院_分析化学学号：2052013115155

Research on performance management of HL company

随着国内外市场竞争的日益加剧，人才争夺战愈演愈烈，而科学的人力资源管理在企业管理中的重要性愈发突显，尤其是绩效管理对人才的激励作用也受到越来越多企业的重视。但由于大多数企业管理基础薄弱造成绩效管理推进不力，绩效管理工作常常流于形式、敷衍了事。HL公司是一家省属的国有海员外派机构，本文选取了HL公司内部的绩效管理系统作为研究对象，通过深入学习和探讨研究绩效管理的理论和方法，从分析公司绩效管理现状入手，发现HL公司存在的一系列问题，并以现代企业的绩效管理方法为指导提出改善原绩效管理的方案。具体包括： 一、对HL公司的绩效管理系统进行了再设计。通过对公司现状的分析，提出了设计思路和原则，阐明了公司...In the increasingly competitive domestic and international market environments, quality human resource management has become an important factor to win the competition for enterprises. As one of the primary HR management methods, the Performance Management System has gained more attention from companies' managers. Unfortunately, PMS isn't as effective as it often should be due to weak management p...学位：工商管理硕士院系专业：管理学院_工商管理硕士(工商管理硕士)学号：1792010115067

The Enlightenment of the Cash-Flow Tax for China's Further Corporate Income Tax Reform

世界范围内的税制改革风潮正在兴起，我国目前也正处于新一轮税制改革的全面启动阶段。公司所得税（corporateincometax，以下简称CIT）是各国税收制度中一个较为重要的税种，由于CIT的内在缺陷，虽然改革所得税能暂时缓解其引起的相关问题，但无法根本解决。在这样背景下，现金流量税（cash-flowtax，以下简称CFT）尤其是公司现金流量税（corporatecash-flowtax,以下简称CCFT）理论便为满足这样的要求提供了一个可供借鉴的改革理念。相比CIT，CCFT可以大大简化税制，使税基的确认更为方便；减少逃税的可能性并能保持税制中性，促进储蓄、投资和经济的长期增长。 本文...At present, a wave of tax reform is being on in the world. As one of the most important taxes in tax system, corporate income tax (hereinafter referred to as CIT) reform can only temporarily ease its existing problems, but not fundamentally. In this context, the theory of cash-flow tax (referred to as CFT), especially the corporate cash flow tax (referred to as CCFT) would refine the present CIT. ...学位：经济学硕士院系专业：经济学院财政系_财政学(含税收学)学号：1552006115089

Analysis of Establishing Indicator System of Performance Evaluation of Civil Servant

在经济全球化的今天，建设高绩效的政府正在成为中国各级政府的共识，各种新的管理理念、技术和方法不断在政府部门得到运用。作为一种新的管理理念和手段，公务员绩效评估被引进政府人力资源管理领域。与传统的人事考核相比，公务员绩效评估更加符合现代政府人力资源管理的需要，这一点特别体现在指标体系上。科学的公务员绩效评估指标体系，有利于对公务员的德才表现和工作情况做出公平合理的评价，为公务员的奖惩、培训、辞退等管理工作提供准确可靠的标准，是公务员管理工作中一个极为重要的环节。 公务员考核在我国实施十多年来收到较好的效果，但也暴露出一些弊端和不足，如缺少量化指标、重经济指标、形式化等问题。党的十七届二中全会通...With economic globalization nowadays, all kinds of new managing ideas, technologies and methods are being taken by departments of government. As a new method, performance evaluation is also being taken into HRM of government. Intrinsic traditional methods and tools of human-affair assessment had already felled short of modern HRM of government, should be taken new indicator system of civil servant...学位：管理学硕士院系专业：公共事务学院公共管理系_行政管理学号：2005130059

ClinicalApplication of Diabetes Care Mode Supported by PDA

目的 以PDA（个人数字助理）为平台,建立糖尿病专科护理新模式,使责任护士对患者病情及并发症能及时观察及处理,促进糖尿病专科护理发展。方法 在PDA上设置糖尿病专科疾病的评估内容、并发症处置及高危因素的评估项目,并将评估及处置内容转化为电子病历。结果 PDA糖尿病专科疾病护理模式建立后,患者健康教育满意率较前提高,由96.3%提高至99.6%;护士糖尿病专科理论知识水平较前有提高,由86.1提高至89.4分,差异均有统计学意义（P〈0.05）;评估及处置内容转化为电子病历后,书写时间平均缩短1.3 min。结论 通过PDA建立糖尿病专科疾病护理模式能有效提高责任护士对病情观察、并发症发现及处理的能力及工作效率,很好地提高了护理内涵建设,真正为糖尿患者者提供专业化的优质护理。Objective With the PDA （personal digital assistant） as the platform, the new nursing mode of diabetes care was established, which can make the responsible nurses observe and deal with the patient＇s condition and complications in a timely manner, and promote the development of diabetes care. Methods On the PDA, the evaluation items of diabetic diseases, the treatment of complications and the evaluation of high risk factors were set up, and the contents of evaluation and disposal were transformed into electronic medical records. Results The establishment of PDA disease diabetes specialist nursing mode after health education, patients satisfaction rate improved, increased from 96.3% to 99.6%; the level of theoretical knowledge to improve diabetes specialist nurses than before, increased from 86.1 to 89.4, the differences were statistically significant （P 〈 0.05）; After the evaluation and disposal of the content into electronic medical records, the average writing time was shortened by 1.3 min. Conclusion PDA through the establishment of diabetes specialist nursing mode can effectively improve the nurses of observation, complication and processing ability and work efficiency, greatly improve the connotation of the conslruction of nursing professional, really provide quality care for diabeticpatients

纳流液相分离与电感耦合等离子体质谱联用技术研究新进展

高效微纳液相分离技术如纳流液相色谱、毛细管电泳、微芯片色谱/电泳等与电感耦合等离子体质谱(ICP-MS)检测技术联用,既具有前端分离技术高选择性、高灵敏度、快速、低样品消耗的特点,又结合了后端ICP-MS检测分辨率高、动态范围宽、可绝对定量等优势,正在发展成为一种重要的高内涵联用分析手段。该文对近年来纳流液相分离与ICP-MS联用装置的发展作一系统介绍,对其在化学与生物化学分析等领域的应用予以综述,并展望了该联用技术的发展前景。国家自然科学基金(21475110,21535007,J1310024);;厦门市科技计划项目(3502Z20173019);;中央高校基本科研业务费(20720160051)~

Analysis of Defects in the Clinical Specimens and Observation on Effect of Process Reengineering

目的 对临床标本送检流程进行改进,规范标本的储存和运送流程,以降低临床标本的不合格率。方法 成立标本流程再造团队,统计2014年1—12月及2015年1—12月的不合格的检验标本,绘制标本采集运送流程,分析临床标本送检的流程,对存在的缺陷环节进行分析,进而制定改进措施,对标本的采集、标本的存储、交接及运送进行流程优化再造。对比再造流程前后标本送检的不合格率。结果 标本不合格率由2014年的2.73‰下降至2015年的2.12‰（P〈0.01）。结论 对临床标本运送流程进行分析改进,有效降低标本不合格率,提高标本管理的有效性,确保医疗护理安全。Objective To improve the procedure of clinical specimen delivery, standardize the storage and delivery of specimens, so as to reduce the disqualification rate of clinical specimens. Methods Specimen reengineering team was established, and unqualified specimens from January to December 2014 and January to December 2015 were collected. Drawing specimen collection and transportation process, and the existing defects were analyzed, then the improvement measures are made. The process of specimen collection, specimen storage, hand over and delivery was optimized. The unqualified rate of the sample before and after the reconstruction process was compared. Results The rate of unqualified specimens declined from 2.73%0 in 2014 to 2.12‰ in 2015 （P 〈 0.01）. Conclusion The analysis and improvement of clinical specimen delivery process can effectively reduce the rate of specimen failure, improve the effectiveness of specimen management, and ensure the safety of medical care

Aerodynamic characteristics research on wide-speed range waverider configuration

Waverider generated from a given flow field has a high lift-to-drag ratio because of attached bow shock on leading edge. However, leading edge blunt and off-design condition can make bow shock off leading edge and have unfavorable influence on aerodynamic characteristics. So these two problems have always been concerned as important engineering science issues by aeronautical engineering scientists. In this paper, through respectively using low speed and high speed waverider design principles, a wide-speed rang vehicle is designed, which can level takeoff and accelerate to hypersonic speed for cruise. In addition, sharp leading edge is blunted to alleviated aeroheating. Theoretical study and wind tunnel test show that this vehicle has good aerodynamic performance in wide-speed range of subsonic, transonic, supersonic and hypersonic speeds

中药沐足结合护理干预治疗护理人员下肢静脉曲张的效果观察

目的探讨中药沐足结合护理干预在下肢静脉曲张护士中的应用效果。方法选取某三甲综合性医院患有下肢静脉曲张的临床护士60例为研究对象,应用随机数字表法分为两组,各30例。两组研究对象均行基础护理,对照组采用医用的循序减压弹力袜进行治疗,观察组实施中药沐足结合护理干预措施。2个月后比较两组患者疗效。结果观察组研究对象静脉曲张恢复总有效率高于对照组,观察组研究对象经过3个疗程的治疗,痊愈12例,显效l3例,有效4例;对照组分别为痊愈5例,显效8例,有效9例;观察组、对照组临床治愈率和总有效率分别为40.00%、96.67%和16.67%、73.33%。差异有统计学意义(P<0.05)。结论中药沐足结合护理干预可以改善下肢静脉曲张的临床症状。福建中医药大学2016年临床专项校管课题(XB2016085

Well Width Dependence of Band Gap Renormalization of Single ZnO/MgZnO Quantum Well

通过室温下的时间积分光致发光(Pl)谱,研究了阱宽lW渐变的znO/Mg0.1zn0.9O单量子阱在高激发强度下的能带重正化与阱宽的关系。实验中光生载流子浓度为n=1.6x1014CM-2,在lW从2.3 nM渐变到4.3 nM,Pl谱峰位的红移量从5.9 MEV变化到97.1 MEV。红移量随阱宽增大而增加,但增加率却逐渐减少。当lW>2αb(αb,znO体材料激子玻尔半径,约为2 nM)时,红移量逐渐呈现出饱和的趋势(100 MEV)。研究发现峰位的红移是由于多体效应所导致的能隙收缩以及在高的激发强度下带内填充效应的这两种机理相互竞争的结果。Band gap renormalization of ZnO/Mg0.1Zn0.9O single quantum well(QW) with gradual well width(Lw) is studied by room-temperature time integrated photoluminescence(PL) spectra at high excitation power density.The photo-generated carrier density is n=1.6×1014 cm-2 and the magnitude of red shift of PL spectrum peak increases from 5.9 meV to 97.1 meV with Lw changing from 2.3 nm to 4.3 nm.With Lw increaseing,the red shift increases but the increase rate gradually decreases.When Lw>2αB(αB,the exciton Bohr radius of ZnO bulk,is about 2 nm),the red shift starts to be gradually saturated.It is found that the red shift is the competition result of energy gap contraction due to many body effect and intraband filling effect at high excitation power density.The result is useful for designing and application of ZnO QW-based optoelectronic devices.国家973计划(2004CB719804);国家自然科学基金(60876007);广州市科技局推荐项目(2005Z3-C7451)资助课