11 research outputs found
Epicardial Fat Tissue and Coronary Artery Disease
Epikardijalno masno tkivo (EMT) ekstraabdominalno je visceralno masno tkivo smjeÅ”teno izmeÄu miokarda i visceralnog lista perikarda s kojima je embrioloÅ”ki, anatomski i funkcionalno povezano. Debljina epikardijalnoga masnog tkiva danas je prepoznata kao nezavisni riziÄni Äimbenik koronarne bolesti srca (KBS), o Äemu svjedoÄi sve veÄi broj kliniÄkih studija. PoveÄani volumen epikardijalnoga masnog tkiva povezan je s kroniÄnom upalom i poveÄanim luÄenjem proupalnih citokina koji pogoduju i promoviraju proces aterogeneze. Standardiziranim postupkom ultrazvuÄnog mjerenja debljine epikardijalnoga masnog tkiva lateralnog zida desnog ventrikula može se s velikom sigurnoÅ”Äu predvidjeti postojanje KBS-a, a uz pomoÄ kompjutorizirane tomografije ili magnetske rezonancije predvidjeti i rizik od moguÄega koronarnog dogaÄaja. Povezanost debljine i upale epikardijalnoga masnog tkiva s KBS-om nameÄe ideju o potencijalnim terapijskim intervencijama radi usporavanja procesa aterogeneze.Epicardial fat tissue is extraabdominal visceral fat tissue located between the myocardial muscle and the visceral pericard and connected to it embryonally and functionally. A large number of clinical studies support the claim that the epicardial adipose tissue thickness is an independent risk factor for coronary disease. The enlarged volume of the epicardial fat tissue is connected to chronical inflammation and strong production of anti inflammatory cytokines which entice the atherogenesis. Coronary disease can be predicted by standard measurement of the epicardial fat thickness of the right ventricle lateral wall. Thus it is possible to predict the risk of a coronary incident by conducting a CT or MR scan. The correlation between epicardial fat thickness and inflammation of the fat tissue suggests the possibility of potential therapeutical interventions with the aim to delay aterogenesis
The heart frequency and it\u27s variability in hypertensive patients considering A/B type of behaviour and eight basic emotions and levels of anger expression
U ovom radu istraživali smo autonomnu regulaciju rada srca putem frekvencije srca i njene varijabilnosti kod 100 bolesnika s
esencijalnom hipertenzijom i usporedili sa 100 ispitanika zdrave kontrolne grupe. Bolesnici s esencijalnom hipertenzijom imali su
znaÄajno kraÄi prosjeÄni RR interval, odnosno bržu frekvenciju srca nego kontrolna grupa. ProsjeÄna varijabilnost frekvencije srca
je statistiÄki znaÄajno niža u hipertenzivnoj, nego u zdravoj kontrolnoj grupi. Na frekvenciju srca i njenu varijabilnost ukupno
znaÄajno utjeÄu, pri mirnom i dubokom disanju: sistoliÄki tlak, dijastoliÄki tlak, masa lijevog ventrikula, dijastoliÄka disfunkcija
lijevog ventrikula, veliÄina lijevog atrija, trajanje hipertenzije, visina kolesterola i triglicerida. NajznaÄajnija negativna povezanost
naÄena je izmeÄu varijabilnosti frekvencije srca i trajanja hipertenzije. U hipertenzivnih bolesnika i u kontrolnoj skupini ÄeÅ”Äi je āA
tipā nego āB tipā ponaÅ”anja. U hipertenzivnoj grupi statistiÄki je znaÄajan ukupan utjecaj svih nezavisnih varijabli po Bortneru na
varijabilnost frekvencije srca pri mirnom disanju. Frekvencija srca i njena varijabilnost povezane su sa osam temeljnih emocija
kodu hipertenzivnih ispitanika i kontrolne skupine. U grupi hipertenzivnih bolesnika varijabilnost frekvencije srca znaÄajno je
pozitivno povezana s emocionalnom dimenzijom āInkorporacijaā, a negativno s emocionalnim dimenzijama āZaÅ”titaā,
āOdbacivanjeā i āReprodukcijaā. NaÅ”i podaci pokazuju da bolesnici s dugotrajnom hipertenzijom imaju poviÅ”enu frekvenciju srca i
reduciranu varijabilnost frekvencije srca, Å”to su poznati Äimbenici rizika za poviÅ”eni kardijalni mortalitet.The aim of this paper was to comparation between autonomic regulation of the heart rate and it\u27s variability within 100 essential
hypertensive patients and 100 examinees in healthy control group. Essential hypertensive patients had significantly shorter
average RR interval, that is, faster heart frequency then the control group. Average variability of the heart frequency was
statisticaly considerably lower in hypertensive than in the healthy control group. Sistolic blood pressure, diastolic blood pressure,
duration of hypertension, levels have considerate total influence on heart frequency and it\u27s variability during calm and during
deep breathing. The most distinctive negative connection was found between variability of the heart frequency and duration of
hypertension. The type A behaviour within hypertensive patients and the control group was more common then type B. In the
hypertensive group, total influence of all independent Bortner\u27s variables on to variability of the heart frequency during calm
breathing was statisticaly important. Within hypertensive patients and the control group, the heart frequency and it\u27s variability
were connected with eight basic emotions. In the group of hypertensive patients variability of the heart frequency is significantly
positively connected with emotional dimension "Incorporation", but negatively with emotional dimensions "Protection",
"Rejection" and "Reproduction". Our data showes that patients with long-term hypertension have increased heart frequency
and reduced variability of the heart frequency, which are well-known risk factors for increased cardial mortality
The Heart Frequency and Its Variability in Hypertensive Patients Considering A/B Type of Behaviour and Eight Basic Emotions and Levels of Anger Expression
The aim of this paper was to comparation between autonomic regulation of the heart rate and itās variability within 100 essential hypertensive patients and 100 examinees in healthy control group. Essential hypertensive patients had significantly shorter average RR interval, that is, faster heart frequency then the control group. Average variability of the heart frequency was statisticaly considerably lower in hypertensive than in the healthy control group. Sistolic blood pressure, diastolic blood pressure, duration of hypertension, levels have considerate total influence on heart frequency and itās variability during calm and during deep breathing. The most distinctive negative connection was found between variability of the heart frequency and duration of hypertension. The type A behaviour within hypertensive patients and the control group was more common then type B. In the hypertensive group, total influence of all independent Bortnerās variables on to variability of the heart frequency during calm breathing was statisticaly important. Within hypertensive patients and the control group, the heart frequency and itās variability were connected with eight basic emotions. In the group of hypertensive patients variability of the heart frequency is significantly positively connected with emotional dimension Ā»IncorporationĀ«, but negatively with emotional dimensions Ā»ProtectionĀ«, Ā»RejectionĀ« and Ā»ReproductionĀ«. Our data showes that patients with long-term hypertension have increased heart frequency and reduced variability of the heart frequency, which are well-known risk factors for increased cardial mortality
Clinical Characteristics of Patients with Spondyloarthritides and HLA-B27 Positive Antigen
The aim of this study was to present our experiences in diagnosing spondyloarthritides (SpA), and to list the most
common clinical features of HLA-B 27 positive patients.The study included 65 HLA-B 27 positive patients with confirmed
diagnosis of ankylosing spondylitis(AS) and psoriatic arthritis (PsA) who were analyzed between 2009 and 2010
in Clinic of Internal Medicine in Osijek. The diagnosis of seronegative spondyloarthritides was based on the ASAS (Assessment
in AS Working Group) classification criteria for axial and then supplemented with ASAS criteria for peripheral
SpA and was confirmed by radiological techniques. For diagnosing the ankylosing spondylitis (AS), there have been
applied the modified New York criteria. Radiological criteria for definite sacroiliitis according to the modified New York
criteria is bilateral sacroiliitis, grade 2ā4 (2) or unilateral sacroiliitis, grade 3ā4. For diagnosing the psoriatic arthritis
(PsA), there were used CASPAR diagnostic criteria. Other features of SpA are defined within the existing classification
criteria. HLA-B27 antigen was determined by direct immune-fluorescence technique using flow cytometer. The average
age of patients was 50.34 years, of whom 27 female (41.53%), 38 male (58.46%). Duration of illness was 15.79 years on
average.With 75.38% of patients, there had been determined the diagnosis of AS; 24.62% of patients had the diagnosis of
PsA. The most common clinical characteristics that patients had were: inflammatory back pain (pain Inflammation along
the lumbosacral spine), peripheral arthritis, intermittent pain in the gluteus, sacroiliitis, enthesitis, uveitis, dactilitis
Epicardial Fat Tissue and Coronary Artery Disease
Epikardijalno masno tkivo (EMT) ekstraabdominalno je visceralno masno tkivo smjeÅ”teno izmeÄu miokarda i visceralnog lista perikarda s kojima je embrioloÅ”ki, anatomski i funkcionalno povezano. Debljina epikardijalnoga masnog tkiva danas je prepoznata kao nezavisni riziÄni Äimbenik koronarne bolesti srca (KBS), o Äemu svjedoÄi sve veÄi broj kliniÄkih studija. PoveÄani volumen epikardijalnoga masnog tkiva povezan je s kroniÄnom upalom i poveÄanim luÄenjem proupalnih citokina koji pogoduju i promoviraju proces aterogeneze. Standardiziranim postupkom ultrazvuÄnog mjerenja debljine epikardijalnoga masnog tkiva lateralnog zida desnog ventrikula može se s velikom sigurnoÅ”Äu predvidjeti postojanje KBS-a, a uz pomoÄ kompjutorizirane tomografije ili magnetske rezonancije predvidjeti i rizik od moguÄega koronarnog dogaÄaja. Povezanost debljine i upale epikardijalnoga masnog tkiva s KBS-om nameÄe ideju o potencijalnim terapijskim intervencijama radi usporavanja procesa aterogeneze.Epicardial fat tissue is extraabdominal visceral fat tissue located between the myocardial muscle and the visceral pericard and connected to it embryonally and functionally. A large number of clinical studies support the claim that the epicardial adipose tissue thickness is an independent risk factor for coronary disease. The enlarged volume of the epicardial fat tissue is connected to chronical inflammation and strong production of anti inflammatory cytokines which entice the atherogenesis. Coronary disease can be predicted by standard measurement of the epicardial fat thickness of the right ventricle lateral wall. Thus it is possible to predict the risk of a coronary incident by conducting a CT or MR scan. The correlation between epicardial fat thickness and inflammation of the fat tissue suggests the possibility of potential therapeutical interventions with the aim to delay aterogenesis
Epicardial Fat Tissue and Coronary Artery Disease
Epikardijalno masno tkivo (EMT) ekstraabdominalno je visceralno masno tkivo smjeÅ”teno izmeÄu miokarda i visceralnog lista perikarda s kojima je embrioloÅ”ki, anatomski i funkcionalno povezano. Debljina epikardijalnoga masnog tkiva danas je prepoznata kao nezavisni riziÄni Äimbenik koronarne bolesti srca (KBS), o Äemu svjedoÄi sve veÄi broj kliniÄkih studija. PoveÄani volumen epikardijalnoga masnog tkiva povezan je s kroniÄnom upalom i poveÄanim luÄenjem proupalnih citokina koji pogoduju i promoviraju proces aterogeneze. Standardiziranim postupkom ultrazvuÄnog mjerenja debljine epikardijalnoga masnog tkiva lateralnog zida desnog ventrikula može se s velikom sigurnoÅ”Äu predvidjeti postojanje KBS-a, a uz pomoÄ kompjutorizirane tomografije ili magnetske rezonancije predvidjeti i rizik od moguÄega koronarnog dogaÄaja. Povezanost debljine i upale epikardijalnoga masnog tkiva s KBS-om nameÄe ideju o potencijalnim terapijskim intervencijama radi usporavanja procesa aterogeneze.Epicardial fat tissue is extraabdominal visceral fat tissue located between the myocardial muscle and the visceral pericard and connected to it embryonally and functionally. A large number of clinical studies support the claim that the epicardial adipose tissue thickness is an independent risk factor for coronary disease. The enlarged volume of the epicardial fat tissue is connected to chronical inflammation and strong production of anti inflammatory cytokines which entice the atherogenesis. Coronary disease can be predicted by standard measurement of the epicardial fat thickness of the right ventricle lateral wall. Thus it is possible to predict the risk of a coronary incident by conducting a CT or MR scan. The correlation between epicardial fat thickness and inflammation of the fat tissue suggests the possibility of potential therapeutical interventions with the aim to delay aterogenesis
Epicardial Adipose Tissue Is Nonlinearly Related to Anthropometric Measures and Subcutaneous Adipose Tissue
Introduction. Adipose tissue is the largest endocrine organ, composed of subcutaneous (SAT) and visceral adipose tissue (VAT), the latter being highly associated with coronary artery disease (CAD). Expansion of epicardial adipose tissue (EAT) is linked to CAD. One way of assessing the CAD risk is with low-cost anthropometric measures, although they are inaccurate and cannot discriminate between VAT and SAT. The aim of this study is to evaluate (1) the relationship between EAT thickness, SAT thickness and anthropometric measures in a cohort of patients assessed at the cardiology unit and (2) determine predictive power of anthropometric measures and EAT and SAT thickness in establishment of CAD. Methods. Anthropometric measures were obtained from 53 CAD and 42 non-CAD patients. Vascular and structural statuses were obtained with coronarography and echocardiography, as well as measurements of the EAT and SAT thickness. Results. Anthropometric measures showed moderate positive correlation with EAT and SAT thickness. Anthropometric measures and SAT follow nonlinear S curve relationship with EAT. Strong nonlinear power curve relationship was observed between EAT and SAT thinner than 10 mm. Anthropometric measures and EAT and SAT were poor predictors of CAD. Conclusion. Anthropometric measures and SAT have nonlinear relationship with EAT. EAT thickness and anthropometric measures have similar CAD predictive value
Epicardial Adipose Tissue Is Nonlinearly Related to Anthropometric Measures and Subcutaneous Adipose Tissue
Introduction. Adipose tissue is the largest endocrine organ, composed of subcutaneous (SAT) and visceral adipose tissue (VAT), the latter being highly associated with coronary artery disease (CAD). Expansion of epicardial adipose tissue (EAT) is linked to CAD. One way of assessing the CAD risk is with low-cost anthropometric measures, although they are inaccurate and cannot discriminate between VAT and SAT. The aim of this study is to evaluate (1) the relationship between EAT thickness, SAT thickness and anthropometric measures in a cohort of patients assessed at the cardiology unit and (2) determine predictive power of anthropometric measures and EAT and SAT thickness in establishment of CAD.
Methods. Anthropometric measures were obtained from 53 CAD and 42 non-CAD patients. Vascular and structural statuses were obtained with coronarography and echocardiography, as well as measurements of the EAT and SAT thickness.
Results. Anthropometric measures showed moderate positive correlation with EAT and SAT thickness. Anthropometric measures and SAT follow nonlinear S curve relationship with EAT. Strong nonlinear power curve relationship was observed between EAT and SAT thinner than 10āmm. Anthropometric measures and EAT and SAT were poor predictors of CAD.
Conclusion. Anthropometric measures and SAT have nonlinear relationship with EAT. EAT thickness and anthropometric measures have similar CAD predictive value