Yaşla Beraber Ön Segment Parametrelerindeki Değişimin Dual Scheimpflug Topografi ile Değerlendirilmesi

Objective: The aim of this study was to investigate the changes according to age in anterior segment parameters measured by Galilei Dual Scheimpflug Analyzer. Material and Methods: Healthy subjects were recruited and classified into seven groups according to age. Group 1 consisted of subjects whose ages ranged between 5 and 10 years. Group 2, 3, 4, 5, 6, 7 consisted of subjects who were in their second, third, forth, fifth, sixth and seventh decades, respectively. After a detailed examination, anterior segment parameters were assessed by using Galilei Dual Scheimpflug Analyzer. The following parameters were obtained from topographic and pachymetric maps for analysis: anterior chamber angle (ACA), anterior chamber depth (ACD), anterior chamber volume (ACV), central corneal thickness (CCT), pupil diameter (PD) and corneal horizontal diameter (CHD). Statistical analysis was performed by using SPSS for Windows version 23.0. Results: The age of subjects ranged between 5 and 67 years. Of 229 subjects, 152 (66.4%) were female and 77 (33.6%) were male. The decrease in CCT, CHD, PD, ACD and ACA with age was statistically significant and a negative correlation was present (p=0.000). Except Group 1, the decline in ACV by increasing age was statistically significant and a negative correlation was present [r (458) =-0.34. p=0.000]. Conclusion: All anterior segment parameters except mean ACV measured by Galilei Dual Scheimpflug Analyzer were found to decline with age and mean ACD achieved to adult size till the beginning of the second decadeAmaç: Yaşla beraber ön segment parametrelerindeki değişimin Galilei Dual Scheimpflug Topografi ile değerlendirilmesi. Gereç ve Yöntemler: Çalışmaya sağlıklı denekler alınarak yaşlarına göre 7 gruba ayrıldı. Grup 1’deki deneklerin yaşları 5 ile 10 arasında idi. Grup 2, 3, 4, 5, 6 ve 7 ise yaşları sırasıyla ikinci, üçüncü, dördüncü, beşinci, altıncı ve yedinci on yıllarında olan deneklerden oluşturuldu. Detaylı göz muayenesinden sonra Galilei Dual Scheimpflug Topografi ile ön segment parametreleri değerlendirildi. Ön kamara açısı (ÖKA), ön kamara derinliği (ÖKD), ön kamara hacmi (ÖKH), merkezi kornea kalınlığı (MKK), pupilla çapı (PÇ) ve horizontal kornea çapı (KÇ) değerleri topografik ve pakimetrik haritalar incelenerek değerlendirildi. İstatistiksel analiz SPSS 23,0 programı ile yapıldı. Bulgular: Çalışmaya katılan 229 deneğin yaşları 5 ile 67 arasında değişmekte ve 152’si (%66,4) kadın, 77’si (%33,6) ise erkekti. Analiz sonucunda MKK, KÇ,PÇ, ÖKD ve ÖKA yaşla beraber azalmakta ve yaş ile bu değerler arasında istatistiksel olarak negatif korelasyon mevcuttu (p=0,000). ÖKH’de ise Grup 1 hariç diğer gruplar arasında yaşla beraber düşme olduğu gözlenmiş ve istatistiksel olarak negatif korelasyon bulunmuştur [r (458) =-0,34. p=0,000]. Sonuç: Galilei Dual Scheimpflug topografi ile ortalama ÖKH hariç tüm ön segment parametreleri yaşla birlikte azalmıştır. ÖKD’nin ikinci on yıldan itibaren erişkin boyutuna ulaştığı gözlenmiştir

Prolactin receptor (PRLR) gene polymorphism in Chios, White Karaman and Awassi sheep breeds

The objective of the present study was to determine the polymorphism in the prolactine receptor (PRLR) gene in Chios, White Karaman and Awassi, which are native sheep breeds in Turkey. By means of PRLR gene sequence homology between sheep and humans, two primer pairs were designed for polymerase chain reaction (PCR) amplification within intron 1 and exon 10 of the PRLR gene in sheep. A total of 160 amplicons (99 for intron 1 and 61 for exon 10) were subjected to DNA sequence analysis. For intron 1, 6 different haplotypes were determined. For exon 10, 7 different haplotypes were obtained. Some variations determined for exon 10 (g.14A>T p.Q14L; g.160G>A p.D160N; g.166G>A p.E166K; g.167A>T p.E167V; g.176A>T p.H176L; g.206G>A p.S206N; g.208G>A p.G208R) led to changes in the amino acids, but no amino acid changes were determined in g.2A>T, g.81A>G, g.138A>G, g.186C>T, g..207T>C. It was noted in particular that White Karaman and Awassi were similar to each other in both PRLR exon 10 and intron 1 haplotypes, whereas the Chios breed had a different variation.TubitakTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Council of Firat UniversityFirat University [1070894]The sequence experiments were carried out at the Ankara University Biotechnology Institute Genomics Unit. The Project was supported by Tubitak and Scientific Research Projects Council of Firat University (Project code Tubitak 1070894; Fubap: 1502)

Yalın Yönetim ve Örgütsel Güvene Yönelik Algının Örgütsel Özdeşleşmeye Etkisi: Özel Bir Hastanede Araştırma

Bu çalışmada yalın yönetim, örgütsel özdeşleşme ve örgütsel güven değişkenleri arasındaki ilişkilerin incelenmesi amaçlanmıştır. Çalışmanın evreni, İzmir ilinde bulunan özel bir hastanede görev yapan hemşireler ve diğer sağlık çalışanlarından oluşmaktadır. Çalışmada örneklem seçilmemiş, tüm evrene erişilmeye çalışılmış ve böylece 121 kişi çalışmaya katılım sağlamıştır. Çalışmada yapılan analizler sonucunda katılımcıların yalın yönetim, örgütsel özdeşleşme ve örgütsel güven algılarının yüksek düzeyde olduğu tespit edilmiştir. Çalışmada gerçekleştirilen korelasyon analizine göre, yalın yönetim ile örgütsel özdeşleşme; yalın yönetim ile örgütsel güven ve örgütsel özdeşleşme ile örgütsel güven arasında pozitif ve orta düzeyde ilişkiler tespit edilmiştir. Regresyon analizine göre yalın yönetim algısının örgütsel özdeşleşme üzerindeki toplam varyansın %26.6’sını ve örgütsel güven üzerindeki toplam varyansın %33.9’unu; örgütsel güven algısının ise örgütsel özdeşleşme üzerindeki toplam varyansın %38.9’unu açıkladığı belirlenmiştir

Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahceehir (Istanbul) Breast Cancer Screening Project in Turkey

PURPOSE The Turkish Bahceehir Breast Cancer Screening Project was a 10-year, organized, population-based screening program carried out in Bahceehir county, Istanbul. Our aim was to examine the biologic features and outcome of screen-detected and interval breast cancers during the 10-year study period. METHODS Between 2009 and 2019, 2-view mammograms were obtained at 2-year intervals for women aged 40 to 69 years. Clinicopathological characteristics including ER, PR, HER2-neu, and Ki-67 status were analyzed for those diagnosed with breast cancer. RESULTS In 8,758 screened women, 131 breast cancers (1.5%) were detected. The majority of patients (82.3%) had prognostic stage 0-I disease. Contrarily, patients with interval cancers (n = 15; 11.4%) were more likely to have a worse prognostic stage (II-IV disease; odds ratio [OR], 3.59, 95% CI, 0.9 to 14.5) and high Ki-67 scores (OR, 3.14; 95% CI, 0.9 to 11.2). Interval cancers detected within 1 year were more likely to have a luminal B (57.1% v 31.9%) and triple-negative (14.3% v 1%) subtype and less likely to have a luminal A subtype (28.6% v 61.5%; P = .04). Patients with interval cancers had a poor outcome in 10-year disease-specific (DSS) and disease-free survival (DFS) compared with those with screen-detected cancers (DSS: 68.2% v 98.1%, P = .002; DFS: 78.6% v 96.5%, P = .011). CONCLUSION Our findings suggest the majority of screen-detected breast cancers exhibited a luminal A subtype profile with an excellent prognosis. However, interval cancers were more likely to have aggressive subtypes such as luminal B subtype or triple-negative cancers associated with a poor prognosis requiring other preventive strategies. (c) 2020 by American Society of Clinical OncologyRocheRoche Holding; Basaksehir (Basaksehir county in Istanbul) MunicipalitySupported by a grant from Roche (V.O.) and Basaksehir (Bahcesehir is a region in the Basaksehir county in Istanbul) Municipality

Cost-Effectiveness of Breast Cancer Screening in Turkey, a Developing Country: Results from Bahçeşehir Mammography Screening Project

Objective: We used the results from the first three screening rounds of Bahcesehir Mammography Screening Project (BMSP), a 10-year (20092019) and the first organized population-based screening program implemented in a county of Istanbul, Turkey, to assess the potential cost-effectiveness of a population-based mammography screening program in Turkey. Materials and Methods: Two screening strategies were compared: BMSP (includes three biennial screens for women between 40-69) and Turkish National Breast Cancer Registry Program (TNBCRP) which includes no organized population-based screening. Costs were estimated using direct data from the BMSP project and the reimbursement rates of Turkish Social Security Administration. The life-years saved by BMSP were estimated using the stage distribution observed with BMSP and TNBCRP. Results: A total of 67 women (out of 7234 screened women) were diagnosed with breast cancer in BMSP. The stage distribution for AJCC stages O, I, II, III, IV was 19.4%, 50.8%, 20.9%, 7.5%, 1.5% and 4.9%, 26.6%, 44.9%, 20.8%, 2.8% with BMSP and TNBCRP, respectively. The BMSP program is expected to save 279.46 life years over TNBCRP with an additional cost of $677.171, which implies an incremental cost-effectiveness ratio (ICER) of$ 2.423 per saved life year. Since the ICER is smaller than the Gross Demostic Product (GDP) per capita in Turkey ($ 10.515 in 2014), BMSP program is highly cost-effective and remains cost-effective in the sensitivity analysis. Conclusion: Mammography screening may change the stage distribution of breast cancer in Turkey. Furthermore, an organized population-based screening program may be cost-effective in Turkey and in other developing countries. More research is needed to better estimate life-years saved with screening and further validate the findings of our study.Roche Turkey; Breast Health Society of Turkey (MEMEDER); Clinical and Translational Science Award (CTSA) program, through the NIH National Center for Advancing Translational Sciences (NCATS)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000427]; NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000427] Funding Source: NIH RePORTERThe study was funded by Roche Turkey and in part by the Breast Health Society of Turkey (MEMEDER). Also, it was partially supported by the Clinical and Translational Science Award (CTSA) program, through the NIH National Center for Advancing Translational Sciences (NCATS), grant UL1TR000427. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH

Radiologic findings of screen-detected cancers in an organized population-based screening mammography program in Turkey

PURPOSE:Bahçeşehir Breast Cancer Screening Program is a population based organized screening program in Turkey, where asymptomatic women aged 40–69 years are screened biannually. In this prospective study, we aimed to determine the mammographic findings of screen-detected cancers and discuss the efficacy of breast cancer screening in a developing country.METHODS:A total of 6912 women were screened in three rounds. The radiologic findings were grouped as mass, focal asymmetry, calcification, and architectural distortion. Masses were classified according to shape, border, and density. Calcifications were grouped according to morphology and distribution. Cancers were grouped according to the clinical stage.RESULTS:Seventy cancers were detected with an incidence of 4.8/1000. Two cancers were detected in other centers and three were not visualized mammographically. Mammographic presentations of the remaining 65 cancers were mass (47.7%, n=31), calcification (30.8%, n=20), focal asymmetry (16.9%, n=11), architectural distortion (3.1%, n=2), and skin thickening (1.5%, n=1). The numbers of stage 0, 1, 2, 3, and 4 cancers were 13 (20.0%), 34 (52.3%), 14 (21.5%), 3 (4.6%), and 1 (1.5%), respectively. The numbers of interval and missed cancers were 5 (7.4%) and 7 (10.3%), respectively.CONCLUSION:A high incidence of early breast cancer has been detected. The incidence of missed and interval cancers did not show major differences from western screening trials. We believe that this study will pioneer implementation of efficient population-based mammographic screenings in developing countries

Synthesis of new calix[4]arene amide derivatives and investigation of their DNA cleavage activity

This study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, 1H NMR, 13C NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III