THE EFFECT OF QUALITY OF FACULTY LIFE ON STUDENT LOYALTY

The purpose of this research is to determine the effect of faculty life quality on student loyalty according to student perceptions. The study was designed in a descriptive relational survey model. The sample of the research consists of 342 undergraduate students studying at Kütahya Dumlupınar University, Faculty of Education in the 2021-2022 academic year. In the study “Quality of faculty life scale” and “Student loyalty scale” were used. In the study, it was found that students' perceptions of the quality of faculty life and student loyalty levels were high. The study revealed a highly positive and significant relationship between the quality of faculty life and student loyalty. In addition, it has been determined that the quality of faculty life is an important predictor of student loyalty. Universities and the Council of Higher Education (CoHE) can periodically measure the perceptions of university students regarding the quality of faculty life and their loyalty, and by evaluating the results they carry out necessary improvement studies

Sipironolactone prevents the heart againts anthracycline cardiotoxicity

Aim:&nbsp;The most important adverse event of anthracyclines is cardiotoxicity and can limit the use of them. Spironolactone is an aldosterone antagonist and has antifibrotic and antioxidant effects. In the present study, we aimed to investigate the effects of spironolactone in the prevention of the cardiotoxic effects of the anthracycline.Materials and methods:&nbsp;A total of 83 female patients who diagnosed with breast cancer and planned anthracycline including chemotherapy regimen were enrolled in to the study. Study population were randomized as spironolactone and control group. Twenty five mg/day spironolactone was administrated to the patients in spironolactone group.Results:&nbsp;LVEF decreased from 67.0&plusmn;6.1 to 65.7&plusmn;7.4 (p=0.094) in the spironolactone group, while from 67.7&plusmn;6.3 to 53.6&plusmn;6.8 in control group (p&lt;0.001). Diastolic functional class was prevented in spironolactone group (p=0.247). In the control group, however, diastolic functional class was deteriorated (p&lt;0.001). Mitral inflow E wave/lateral wall e&#39; wave ratio which is one of the most important sign of the diastolic functions was significantly increased in the control group while prevented in the spironolactone group.</p

Kardiyovasküler kalsifikasyonlar ile koroner arter hastalığı arasındaki ilişki

Çalışmanın amacı koroner anjiyografi yapılan hastalarda, torasik aortadaki aterom plağı kalsifikasyonu veya aort kapak kalsifikasyonu ile koroner arter hastalığı arasındaki ilişkiyi incelemektir. Kardiyovasküler kalsifikasyonlar ile koroner arter hastalığı arasında ilişki olması durumunda, bu kalsifikasyonlar koroner aterosklerozun göstergesi olarak kullanılabilir. Çalışmaya koroner anjiyografi yapılan 1100 hasta alındı. Aort kapak kalsifikasyon varlığı ekokardiyografi ile değerlendirildi. Torasik aortadaki kalsifikasyonları saptamak için PA akciğer grafisi kullanıldı. Çalışmaya alınan 1100 hastanın 812'sinde (%73.8) koroner arter hastalığı saptanırken, 288'inde (%26.2) koronerler normal bulundu. Hastaların 420'sinde (38%) aort kapak kalsifikasyonu ve 180'inde (16%) torasik aorta plak kalsifikasyonu saptandı. Aort kapak kalsifikasyonu saptanan hastalarda, koroner arter hastalığı sıklığı (%88 karşı %65, p<0.0001) ve çok damar hastalığı oranı (%65% karşı %55, p=0.003) daha yüksek bulundu. Koroner arter hastalığı sıklığı ve çok damar hastalığı oranı, torasik aorta plak kalsifikasyonu saptanan hastalarda da yüksek bulundu (sırasıyla, %86 karşı %71, p<0.0001 ve %66 karşı %57, p=0.035). Logistik regresyon analizi ile koroner arter hastalığı risk faktörlerine göre düzeltme yapıldıktan sonra bile, aort kapak kalsifikasyonu (p=0.003) ve torasik aorta plak kalsifikasyonu (p=0.004), koroner arter hastalığı ile ilişkili bulundu. Aort kapak kalsifikasyonu olan hastalarda, torasik aorta plak kalsifikasyonu daha sık izlendi (%23% karşı. %12, p<0.0001). Sonuç olarak, çalşımamızda aort kapak kalsifikasyonu ve torasik aorta plak kalsifikasyonları ile koroner arter hastalığı arasında anlamlı ilişki saptadık. Ayrıca, aort kapak kalsifikasyonu ile torasik aorta plak kalsifikasyonu anlamlı olarak ilişkili idi. Kardiyovasküler kalsifikasyonların varlığı koroner arter hastalığı için bir gösterge olarak düşünülebilir.The aim of this study was to determine whether there is a significant association between calcification of the aortic valve or thoracic aortic calcified plaques and coronary artery disease (CAD) in patients undergoing coronary angiography. If an association could be established between cardiovascular calcifications and CAD, their presence might be used as a marker of coronary atherosclerosis. The study group consisted of 1100 patients who underwent coronary angiography. The presence of aortic valve calcification was identified by echocardiography. Chest X-rays were used to detect calcification in the thoracic aorta. Of the 1100 patients included in the study, 812 (73.8 percent) had CAD, and 288 (26.2 percent) had normal coronary arteries. Aortic valve calcification was present in 420 (38%) and aortic calcified plaques in 180 (16%) of the entire study population. The patients with aortic valve calcification had a significantly higher prevalence of CAD (88% vs 65%, p&lt;0.0001) and higher rates of multivessel disease (65% vs 55%, p=0.003). Also, the prevalence of CAD (86% vs 71%, p&lt;0.0001) and multivessel disease (66% vs 57%, p=0.035) were significantly higher in patients with aortic calcified plaques compared with the patients without aortic calcified plaques. Logistic regression analysis showed that aortic valve calcification (p=0.003) and aortic calcified plaques (p=0.004) were strongly and significantly associated with CAD after adjusting for coronary risk factors. In addition, patients with aortic valve calcification had a high incidence of aortic calcified plaques (23% vs. 12%, p&lt;0.0001). In conclusion, we found a significant association of CAD with the presence of aortic valve calcification and aortic calcified plaques. Our study further demonstrates that aortic valve calcification is significantly associated with calcified plaques in the thoracic aorta. Therefore, the presence of these calcifications should be regarded as a sign for the presence of CAD

Detection of Influenza Virus Infections by Molecular and Immunofluorescence Methods

İnfluenza virüs enfeksiyonları tüm dünyada mevsimsel epidemilere sebep olmanın yanı sıra pandemiler oluşturması sebebiyle de insan sağlığı için son derece önemlidir. İnfluenza yüksek morbidite ile ilişkilidir ve hayatı tehdit eden viral veya bakteriyel pnömoni gibi ciddi komplikasyonlara sebep olabilir. Özellikle küçük çocuklar, ileri yaşta olanlar, kalp hastalığı, akciğer hastalığı, böbrek hastalığı, şeker hastalığı gibi kronik hastalığı olanlar ve immün sistemi baskılanmış kişilerde influenza virüs enfeksiyonlarından kaynaklanan komplikasyonlar ve ölüm riski daha yüksektir. Bu çalışmanın amacı, solunum yolu enfeksiyonu olan ve hastaneye yatırılan hastalarda gerçek zamanlı revers transkriptaz polimeraz zincir reaksiyon (RT-PCR, Sacace, İtalya), konvansiyonel RT-PCR ve direkt immün floresan antikor (Direct immunofluorescence Antibody; DFA, Argene SA, Fransa) testleri ile influenza tip A ve B virüsü enfeksiyonlarının sıklığını ve influenza A virüsü alt tiplerini tespit etmektir. Solunum yolu belirtileri olan toplam 476 hastadan, 01.04.2012-31.12.2013 tarihleri arasında "flocked eküvyon" (Copan Diagnostics, İtalya) ile nazofarengeal sürüntü örnekleri toplanmıştır. RT-PCR testi ile olguların %20.5 (98/476)'inde influenza A virüsü ve %3.3 (16/476)'ünde influenza B virüsü tespit edilmiştir. Çalışma süresi boyunca 98 influenza virüsü izolatının %63.3'ünün influenza A(H1N1)pdm09, %36.7'sinin influenza A(H3N2) alt tipleri olduğu bulunmuştur. İnfluenza A(H1N1)pdm09 alt tipine bağlı en fazla Ocak 2013 tarihinde 12 olgunun, influenza A(H3N2) alt tipine bağlı en fazla Aralık 2013 tarihinde 11 olgunun olduğu gözlenmiştir. Gerçek zamanlı RT-PCR testi referans olarak alındığında influenza A ve B için DFA testinin ve influenza A için Dünya Sağlık Örgütü (DSÖ) primerlerinin (M30F2/08 ve M264R3/08) kullanıldığı konvansiyonel RT-PCR testinin duyarlılığı sırasıyla %72.4, %75, %96 ve özgüllüğü %99.2, %99.5 ve %100 bulunmuştur. Sonuç olarak, çalışma grubunda influenza A virüsü enfeksiyonu oldukça yüksek oranda (%20.5) tespit edilmiştir. İnfluenza virüs tipleri ve alt tiplerinin izlenmesi, influenza aşı suşlarının dolaşımdaki influenza virüsleri ile uyumunun değerlendirilmesi ve pandemik potansiyeli olan alt tiplerin tanısı için gereklidir. İnfluenza virüsü enfeksiyonlarının erken tanısında gerçek zamanlı RT-PCR yöntemi kullanılarak uygun antiviral tedavinin planlanması hastanın tedavi yönetimine önemli katkı sağlayacaktır. Böylece gereksiz ilaç kullanımı önlenecek ve hastalığın etkin tedavisiyle enfeksiyon zamanında kontrol altına alınacaktır.Influenza virus infections are extremely important for human health due to the occurence of seasonal epidemics and pandemics worldwide. Influenza is associated with high morbidity and may result in serious complications such as life threatening viral or bacterial pneumonia. Especially, young children, older adults, patients with chronic diseases such as heart, lung, kidney, and diabetes and immunosuppressed people are at higher risk for complications and death from influenza virus infections. The aim of this study was to determine the incidence of influenza type A and B virus infections and influenza A virus subtypes in hospitalized patients with respiratory tract infections by real-time reverse transcriptase-polymerase chain reaction (RT-PCR, Sacace, Italy), conventional RT-PCR and direct immunofluorescence antibody (DFA, Argene SA, France) tests. Nasopharyngeal swab specimens were collected from a total of 476 patients with respiratory tract symptoms by using flocked swabs (Copan Diagnostics, Italy) between 1 April 2012 and 31 December 2013. Influenza A virus was detected in 20.5% (98/476) and influenza B virus in 3.3% (16/476) of the cases by real-time RT-PCR test. During the study period, 63.3% of 98 influenza virus isolates were found as influenza A(H1N1)pdm09 and 36.7% were influenza A(H3N2) subtypes. Influenza A (H1N1) pdm09 subtype was observed in 12 cases in January 2013 and influenza A(H3N2) subtype was observed in 11 cases in December 2013 as the highest values. When the real-time RT-PCR test was regarded as the reference test, the sensitivities of DFA test for influenza A and B and conventional RT-PCR test with WHO primers (M30F2/08 and M264R3/08) for influenza A were detected as 72.4%, 75%, 96% and the specificities were detected as 99.2%, 99.5% and 100%, respectively. In conclusion, influenza A virus infection was detected rather high with a rate of 20.5% in the study group. The monitoring of influenza virus types and subtypes is required for the evaluation of influenza vaccine strains and circulating influenza viruses and for the identification of subtypes with pandemic potential. Planning for appropriate antiviral therapy using real-time RT-PCR in the early diagnosis of influenza virus infections will significantly contribute to the management of the patient's treatment. Thus, unnecessary drug use will be prevented and controlled with effective treatment of the disease at the time of infection

Relationship between elastic properties of the aorta and uric acid levels in newly diagnosed hypertensive patients

Amaç: Hipertansiyon tanısı yeni konan hastalarda aortun elastik özellikleriyle ürik asit düzeyleri arasındaki ilişki araştırıldı. Çalışma planı: Çalışmaya hipertansiyon tanısı yeni konan 109 hasta (68 kadın, 41 erkek; ort. yaş 51.6±6.9) alındı. Tüm olgularda ekokardiyografik inceleme yapıldı. M-mod ekokardiyografiyle aortun sistolik ve diyastolik çapları ölçüldü, aortun elastik özelliklerinden gerilimi ve esnekliği hesaplandı. Nabız basıncı sfigmomanometreyle ölçüldü. Alınan kan örneklerinde ürik asit düzeyi ve diğer biyokimyasal parametreler ölçüldü. Sonuçlar, yaş ve cinsiyeti hasta grubuyla eşleştirilmiş 21 sağlıklı gönüllüden oluşan kontrol grubuyla karşılaştırıldı. Bulgular: Kontrol grubuyla karşılaştırıldığında, aort gerilimi ve esnekliği hipertansif hastalarda daha düşük (p0.05). Sonuç: Bu bulgular, ürik asidin, özellikle hipertansiyonlu kadın hastalarda aortun bozulan elastik özellikleriyle ilişkili patofizyolojide rol oynayabileceği görüşünü desteklemektedir.Objectives: The association between elastic properties of the aorta and uric acid levels was investigated in patients with newly diagnosed hypertension. Study design: The study included 109 patients (68 females, 41 males; mean age 51.6&plusmn;6.9 years) with newly diagnosed hypertension. Echocardiographic examination was performed. Systolic and diastolic diameters were measured by M-mode echocardiography, and elastic indices (aortic strain and distensibility) were calculated. Pulse pressure was obtained by a sphygmomanometer. Blood samples were obtained to determine serum uric acid levels and other biochemical parameters. The results were compared with those of a control group consisting of 21 age- and sex-matched healthy volunteers. Results: Compared to the control group, aortic strain and distensibility were significantly lower (p&lt;0.001) and uric acid levels were significantly higher (p=0.044) in hypertensive patients. In multivariate regression analysis, aortic strain and distensibility showed independent relationships with uric acid levels (p=0.010 and p=0.009, respectively), age (p=0.001 and p&lt;0.001), and left ventricular mass index (p=0.002 and p&lt;0.001) in the patient group. Multivariate analysis according to gender showed that aortic strain and distensibility were in independent relationship with uric acid levels, age, and left ventricular mass index only in female patients. Conclusion: These data support the view that increased uric acid levels may have a role in the pathogenesis of impaired elastic properties of the aorta especially in hypertensive women