VALIDATION OF THE PARTICLE IN CELL MONTE CARLO COLLISION NUMERICAL CODE FOR THE RF DISCHARGE SIMULATION

We developed 1d3v Particle in Cell/Monte Carlo Collision (PIC/MCC) numerical code for the RF (radio-frequency) capacitive glow discharge. This method includes the solution of the Lorentz force equation for the motion of super particles and the Poisson equation for the electric field. Collisions between the particles are modeled with the Monte Carlo method. In this process, the isotropic and charge exchange collisions between the ion-neutral pairs, as well as the elastic, excitation and ionization collisions between the electron-neutral pairs are taken into account. Test calculations were carried out and numerical code was validated by comparison with the published simulation results

Feline Herpesvirus Type-1 (FeHV-1) ınfection in shelter cats with and without respiratory disorders

Bu çalışmada, sokak kedilerinin toplandığı bir barınaktaki sağlıklı görünüşlü (asemptomatik, n:54) ve solunum sistemi ve/veya konjunktivitis bulgularına sahip (semptomatik, n:21) kedilerden örneklenen nazal ve konjunktival sürüntülerde polimeraz zincir reaksiyonu (PCR) tekniği ile Feline Herpesvirus tip 1 (FeHV-1) prevalansı araştırıldı. Bu amaç- la, 75 adet nazal ve 74 adet konjunktival sürüntü olmak üzere toplam 149 adet örnek toplandı. Örneklenen kedilerin % 25.3'ünde (19/75) FeHV-1 DNA'sı saptandı. Semptomatik kedilerin %47.6'sında (10/21) ve sağlıklı görünüşlü kedilerin %16.7'sinde (9/54) FeHV-1 enfeksiyonu saptandı. Sağlıklı görünüşlü ve klinik bulgulu kedilerde iki yaş grubu (>6 ay ve <6 ay yaşlı) arasındaki enfeksiyon oranları yönünden farklılıklar istatistiksel olarak değerlendirildiğinde, sağlıklı görü- nüşlü grupta farklılığın önemli olduğu belirlendi (P?0.05). Sonuç olarak, FeHV-1'in barınak kedilerinde yüksek prevalansa sahip olduğu tespit edildi.In this study, the prevalence of Feline Herpesvirus type 1 (FeHV-1) was investigated in nasal and conjunctival swabs sampled from the shelter cats that were healthy (asymptomatic n:54) but having respiratory disorder and/or conjunctivitis (symptomatic n:21) housed in an animal shelter using polymerase chain reaction (PCR) technique. Totally, 149 swab samples including 75 nasal and 74 conjunctival swabs were collected. The FeHV-1 DNA was positive in 25.3% (19/75) of all cats sampled. The presence of FeHV-1 infection was determined in 47.6% (10/21) of symptomatic and in 16.7% (9/54) of clinically healthy cats. Moreover, the differences in FeHV-1 infection rates were statistically significant between two age groups (&gt;6 months and &lt;6 months) in clinically healthy appeared cats (P&lt;0.05). In conclusion, FeHV-1 was found prevalent in the shelter cats

Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in tissue engineering applications

Presented work focuses on the development of biodegradable polymer nanoparticles loaded with antibiotics as drug delivery systems deposited on electrospun scaffolds for tissue engineering. The innovative ciprofloxacin-loaded poly(dl-lactide-co-glycolide) NPs ensure a continuous slow release and high local concentration at the site of action for an optimal therapy. The local delivery of antibiotics as an integrated part of electrospun scaffolds offers an effective, safe, and smart enhancement supporting tissue regeneration. Presented data provides solid scientific evidence for fulfilling the requirements of local nano antibiotic delivery systems with biodegradability and biocompatibility for a wide range of tissue engineering applications, including middle ear tissues (e.g., tympanic membranes) which are subject to bacterial infections. Further characterization of such systems, including in vivo studies, is required to ensure successful transfer from lab to clinical applications