9 research outputs found
Age-dependent parathormone levels and different CKD-MBD treatment practices of dialysis patients in Hungary - results from a nationwide clinical audit
BACKGROUND: Achieving target levels of laboratory parameters of
bone and mineral metabolism in chronic kidney disease (CKD)
patients is important but also difficult in those living with
end-stage kidney disease. This study aimed to determine if there
are age-related differences in chronic kidney disease-mineral
and bone disorder (CKD-MBD) characteristics, including treatment
practice in Hungarian dialysis patients. METHODS: Data were
collected retrospectively from a large cohort of dialysis
patients in Hungary. Patients on hemodialysis and peritoneal
dialysis were also included. The enrolled patients were
allocated into two groups based on their age (=65
years). Characteristics of the age groups and differences in
disease-related (epidemiology, laboratory, and treatment
practice) parameters between the groups were analyzed. RESULTS:
A total of 5008 patients were included in the analysis and the
mean age was 63.4+/-14.2 years. A total of 47.2% of patients
were women, 32.8% had diabetes, and 11.4% were on peritoneal
dialysis. Diabetes (37.9% vs 27.3%), bone disease (42.9% vs
34.1%), and soft tissue calcification (56.3% vs 44.7%) were more
prevalent in the older group than the younger group (p<0.001 for
all). We found an inverse relationship between age and
parathyroid hormone (PTH) levels (p<0.001). Serum PTH levels
were lower in patients with diabetes compared with those without
diabetes below 80 years (p<0.001). Diabetes and age were
independently associated with serum PTH levels (interaction:
diabetes x age groups, p=0.138). Older patients were more likely
than younger patients to achieve laboratory target ranges for
each parameter (Ca: 66.9% vs 62.1%, p<0.001; PO4: 52.6% vs
49.2%, p<0.05; and PTH: 50.6% vs 46.6%, p<0.01), and for
combined parameters (19.8% vs 15.8%, p<0.001). Older patients
were less likely to receive related medication than younger
patients (66.9% vs 79.7%, p<0.001). CONCLUSIONS: The achievement
of laboratory target ranges for bone and mineral metabolism and
clinical practice in CKD depends on the age of the patients. A
greater proportion of older patients met target criteria and
received less medication compared with younger patients
A szteroid-rezisztens nephrosis szindróma genetikai vizsgálata Magyarországon
Bevezetés: A szteroid-rezisztens nephrosis szindróma egy rossz
prognózisú kórkép. Immunológiai és
monogénes formájának elkülönítése fontos, mert kezelésük
különböző, de rendszerint csak genetikai vizsgálattal
lehetséges.
Célkitűzés, beteganyag: Célunk a gyakran kóroki NPHS2, WT1 és
NPHS1 gének vizsgálatának hazai bevezetése
volt. Ötvennyolc SRNS vagy nefrotikus mértékű proteinuria miatt
gondozott gyermeket és fiatal
felnőttet vizsgáltunk.
Eredmények: Tizenegy/49 családban találtunk NPHS2, 5/19
családban WT1 és 1/5 gyermeknél NPHS1
mutációt. A tünetek megjelenésének idejében, a vesefunkció
romlásának ütemében és a társuló
extrarenális érintettségben jelentős különbség volt a különböző
gének, és azok különböző mutációi között
is. Míg újszülött- és csecsemőkori megjelenés esetén az esetek
felében, a gyermekkori esetek mindössze
negyedében találtunk kóroki mutációt.
Következtetés: Szteroid-rezisztens nephrosis szindrómában a
mutáció ismerete lehetővé teszi a genetikai
tanácsadást, a prognózis megítélését és meghatározza a terápiát
NPHS2 p.V290M mutation in late-onset steroid-resistant nephrotic syndrome.
BACKGROUND: The most frequently mutated gene of steroid-
resistant nephrotic syndrome (SRNS) is NPHS2. Current guidelines
propose the sequencing of all NPHS2 exons only in childhood-
onset SRNS. METHODS: A cohort of 38 Hungarian patients with
childhood-onset nephrotic-range proteinuria was screened for
NPHS2 mutations. The frequency of the p.V290M mutation in late-
onset SRNS was examined in the French and PodoNet cohorts.
RESULTS: Of the 38 Hungarian patients screened, seven carried
NPHS2 mutations on both alleles, of whom two-diagnosed with
proteinuria through school screening programs at the age of 9.7
and 14 years, respectively-did not develop nephrotic syndrome in
childhood. The first, an 18-year-old boy, homozygous for
p.V290M, has never developed edema. The second, a 31-year-old
woman-compound heterozygous for p.V290M and p.R138Q-was first
detected with hypoalbuminemia (<30 g/l) and edema at the age of
24.3 and 27.5 years, respectively. Both patients currently have
a normal glomerular filtration rate. The mutation p.V290M was
carried by three of the 38 patients in the Hungarian cohort, by
two of the 95 patients with late-onset SRNS in the PodoNet
cohort and by none of the 83 patients in the French cohort.
CONCLUSIONS: We propose that not only the p.R229Q variant, but
also the p.V290M mutation should be screened in Central and
Eastern European patients with late-onset SRNS