27 research outputs found

    ์žฅ๋‚ด์„ธ๊ท ์˜ ๋Œ€์‚ฌ์— ์˜ํ•ด ์กฐ์ ˆ๋˜๋Š” ์ดˆํŒŒ๋ฆฌ์˜ ์„ฑ์žฅ

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    Dept. of Medical Science/๋ฐ•์‚ฌHuman body, consisting of about 10 trillion cells, carries about ten times as many microorganisms in intestines. Recently, the metabolic activities performed by these bacteria have attracted the attention of many researchers. But it is not easy to study this mutualism of host-bacteria interaction in human and mice, because their intestinal microorganisms was composed of too many bacteria species, and host genetic manipulation was intractable.In this regards, Drosophila melanogaster can provide a solution to these disadvantages for studying mutualism more closely. First, all gut flora were considered to be the study of mutualism due to the simple microbial communities of gut microbes Drosophila harboring. In host, germ-free flies could be easily generated and desired microorganism could be easily mono-associated to host. It is well known that genetic modification was tractable.By taking these advantages, we investigated, using Drosophila as a model system, that mutualism between Drosophila and gut bacteria, and observed that normal commensal flora was important for proper development of host, especially in growth-rate and body size, and pronounced in diet-restriction conditions. We also observed that Acetobacter pomorum, a major gut flora of Drosophila, alone could represent the microbial community in Drosophilaโ€™s normal development.In a screen for the factor of Acetobacter pomorum that engaged in hostโ€™s normal development, it is identified that the abilities of Acetobacter pomorum to oxidize ethanol were important for hostโ€™s normal development. These abilities to oxidize ethanol increase the expression of Drosophila insulin like peptides (dilps) in hostโ€™s brain, and these increased level of dilps affect to larval growth and adult body size via the metabolism of larval fat-body. Our results show that ethanol metabolism of Acetobacter pomorum was essential to normal development of host through modulating host metabolic pathway by insulin signaling in Drosophila.prohibitio

    Titre-la langue-peau est-elle possible?

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    KTB ๊ตญ์ฑ„์„ ๋ฌผ์„ ์ด์šฉํ•œ ํ—ค์ง€์„ฑ๊ณผ์— ๋Œ€ํ•œ ๋น„๊ต ์—ฐ๊ตฌ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :๊ฒฝ์˜ํ•™๊ณผ ๊ฒฝ์˜ํ•™์ „๊ณต,2002.Maste

    C. G. Carusโ€™s Nine Letters on Landscape Painting and Geology

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    ์„œ์šธ๋Œ€ํ•™๊ต ๋„์„œ๊ด€ 70๋…„์‚ฌ : 1946-2016

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    | ์ผ๋Ÿฌ๋‘๊ธฐ| 1. ์„œ์šธ๋Œ€ํ•™๊ต ์ค‘์•™๋„์„œ๊ด€์€ 1996๋…„ใ€Ž์„œ์šธ๋Œ€ํ•™๊ต ๋„์„œ๊ด€ ์˜ค์‹ญ๋…„์‚ฌใ€๋ฅผ ํŽธ์ฐฌํ•˜์˜€๋‹ค. ใ€Ž์„œ์šธ๋Œ€ํ•™๊ต๋„์„œ๊ด€70๋…„์‚ฌใ€๋Š”๊ทธ์ „ํ†ต์„์ด์–ด๋ฐ›์•„์ตœ๊ทผ20๋…„์˜๋ณ€ํ™”๋ฅผ์—ญ์‚ฌ๋กœํŽธ ์ž…ํ•˜์—ฌ๋„์„œ๊ด€70๋…„๊ฐ„์˜๋ฐœ์ž์ทจ๋ฅผ๊ฑฐ์‹œ์ ์œผ๋กœ์กฐ๋งํ•˜์˜€๋‹ค. 2.ใ€Ž ์„œ์šธ๋Œ€ํ•™๊ต ๋„์„œ๊ด€ ์˜ค์‹ญ๋…„์‚ฌใ€๋Š” ์‹œ๋Œ€ ์ˆœ์˜ ํŽธ๋…„์ฒด ์„œ์ˆ  ๋ฐฉ์‹์„ ์ทจํ–ˆ์œผ๋ฉฐ,ใ€Ž ์„œ์šธ๋Œ€ ํ•™๊ต ๋„์„œ๊ด€ 70๋…„์‚ฌใ€๋Š” ํŽธ๋…„์ฒด ๊ตฌ์„ฑ๊ณผ ๋ถ„๋ฅ˜์‚ฌ ์ฒด์ œ๋ฅผ ์ ์ ˆํ•˜๊ฒŒ ์ ์šฉํ•˜๊ณ  ๋ถ„์•ผ๋ณ„ ํŠน์ง•์„ ์ข…ํ•ฉํ™”ํ•˜์—ฌ ๋ณด๋‹ค ์‰ฝ๊ฒŒ ์ดํ•ดํ•  ์ˆ˜ ์žˆ๋„๋ก ํ•˜์˜€๋‹ค. ๊ฐœ๊ด€์€ ๋„์„œ๊ด€์˜ ์ „์ฒด ์—ญ ์‚ฌ๋ฅผํ•œ๋ˆˆ์—ํŒŒ์•…ํ• ์ˆ˜์žˆ๋„๋กํŽธ๋…„์ฒด๋กœ๊ตฌ์„ฑํ•˜์˜€๊ณ ๋ถ„์•ผ๋ณ„์„œ์ˆ ์€๋„์„œ๊ด€์—…๋ฌด๋ฅผ ํฌ๊ฒŒ7๊ฐœ๋กœ๋ฒ”์ฃผํ™”ํ•˜์—ฌ์‹œ์„ค๋ฐ๊ณต๊ฐ„, ์กฐ์ง๋ฐ์ธ๋ ฅ, ์žฅ์„œ, ํ•™์ˆ ์ •๋ณดํ™”, ์ด์šฉ์ž์„œ๋น„ ์Šค, ์—ฐ๊ตฌ์ง€์›, ํ™๋ณด๋ฐ๋Œ€์™ธํ˜‘๋ ฅ๋“ฑ์œผ๋กœ๋‚˜๋ˆ„์–ด๋ถ„๋ฅ˜์‚ฌ์ฒด์ œ๋กœ๊ธฐ๋กํ•˜์˜€๋‹ค. 3. ์ด ์ฑ…์€ใ€Ž์„œ์šธ๋Œ€ํ•™๊ต ๋„์„œ๊ด€ ์˜ค์‹ญ๋…„์‚ฌใ€๋ฐœ๊ฐ„ ์ดํ›„ ์ง€๋‚œ 20๋…„๊ฐ„์˜ ์„œ์šธ๋Œ€ํ•™๊ต ์ค‘์•™ ๋„์„œ๊ด€์ด๋ช…์‹ค๊ณตํžˆ์—ฐ๊ตฌ์ค‘์‹ฌ๋Œ€ํ•™๋„์„œ๊ด€์œผ๋กœ๋ฐœ๋‹์›€ํ•˜๋ฉด์„œ๊ฐ๋ถ„์•ผ์—์„œ์ถ”์ง„ํ•˜์˜€ ๋˜ ์ œ๋ฐ˜์˜ ๋ณ€ํ™”๋ฅผ ๊ธฐ์ˆ ํ•˜๋Š”๋ฐ ์ฃผ๋ ฅํ•˜์˜€๋‹ค. ๋”ฐ๋ผ์„œ ์„œ์ˆ  ๋ถ„๋Ÿ‰์˜ ์ ˆ๋ฐ˜ ์ด์ƒ์„ ์—ฌ๊ธฐ์— ํ• ์• ํ–ˆ์œผ๋ฉฐ๊ทธ์ด์ „์‹œ๊ธฐ๋Š”์••์ถ•์ ์œผ๋กœ์„œ์ˆ ํ•˜์˜€๋‹ค. 4. ๋ถ€๋ก์€ใ€Ž์„œ์šธ๋Œ€ํ•™๊ต๋„์„œ๊ด€์˜ค์‹ญ๋…„์‚ฌใ€๋ฅผ๋ฐ”ํƒ•์œผ๋กœ, ์ดํ›„20๋…„๊ฐ„์˜๋‚ด์šฉ์ค‘์ฃผ์š”์‚ฌ ์•ˆ์„์ •๋ฆฌํ•˜์—ฌ๊ธฐ์ˆ ํ•˜์˜€๋‹ค. ๋ถ€๋ก์˜๋‚ด์šฉ์€๊ด€๋ จ๊ทœ์ •๋ฐ๋‚ด๊ทœ, ์กฐ์ง๋ฐ์ง์›, ์—ฐ๋„๋ณ„ ์˜ˆ์‚ฐ๋ฐ๋„์„œ๊ตฌ์ž…๋น„, ์žฅ์„œ๋ฐ์ž๋ฃŒํ˜„ํ™ฉ, ์‹œ์„ค, ์ด์šฉํ†ต๊ณ„, ์—ฐํ‘œ๋กœ๊ตฌ์„ฑํ•˜์˜€๋‹ค
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