Evolutionary Fitness in Variable Environments

One essential ingredient of evolutionary theory is the concept of fitness as a measure for a species' success in its living conditions. Here, we quantify the effect of environmental fluctuations onto fitness by analytical calculations on a general evolutionary model and by studying corresponding individual-based microscopic models. We demonstrate that not only larger growth rates and viabilities, but also reduced sensitivity to environmental variability substantially increases the fitness. Even for neutral evolution, variability in the growth rates plays the crucial role of strongly reducing the expected fixation times. Thereby, environmental fluctuations constitute a mechanism to account for the effective population sizes inferred from genetic data that often are much smaller than the census population size.Comment: main: 5 pages, 4 figures; supplement: 7 pages, 7 figue

Structures and intermittency in a passive scalar model

A one-dimensional white-in-time passive scalar model is introduced. Strong and persistent structures are shown to be present. A perturbative expansion for the scaling exponents is performed around a Gaussian limit of the model. The resulting predictions are compared with numerical simulations.Comment: 8 pages, 4 figure

An evolutionary and functional assessment of regulatory network motifs.

BackgroundCellular functions are regulated by complex webs of interactions that might be schematically represented as networks. Two major examples are transcriptional regulatory networks, describing the interactions among transcription factors and their targets, and protein-protein interaction networks. Some patterns, dubbed motifs, have been found to be statistically over-represented when biological networks are compared to randomized versions thereof. Their function in vitro has been analyzed both experimentally and theoretically, but their functional role in vivo, that is, within the full network, and the resulting evolutionary pressures remain largely to be examined.ResultsWe investigated an integrated network of the yeast Saccharomyces cerevisiae comprising transcriptional and protein-protein interaction data. A comparative analysis was performed with respect to Candida glabrata, Kluyveromyces lactis, Debaryomyces hansenii and Yarrowia lipolytica, which belong to the same class of hemiascomycetes as S. cerevisiae but span a broad evolutionary range. Phylogenetic profiles of genes within different forms of the motifs show that they are not subject to any particular evolutionary pressure to preserve the corresponding interaction patterns. The functional role in vivo of the motifs was examined for those instances where enough biological information is available. In each case, the regulatory processes for the biological function under consideration were found to hinge on post-transcriptional regulatory mechanisms, rather than on the transcriptional regulation by network motifs.ConclusionThe overabundance of the network motifs does not have any immediate functional or evolutionary counterpart. A likely reason is that motifs within the networks are not isolated, that is, they strongly aggregate and have important edge and/or node sharing with the rest of the network

Intermittency in passive scalar advection

A Lagrangian method for the numerical simulation of the Kraichnan passive scalar model is introduced. The method is based on Monte--Carlo simulations of tracer trajectories, supplemented by a point-splitting procedure for coinciding points. Clean scaling behavior for scalar structure functions is observed. The scheme is exploited to investigate the dependence of scalar anomalies on the scaling exponent $\xi$ of the advecting velocity field. The three-dimensional fourth-order structure function is specifically considered.Comment: 4 pages, 5 figure

Active vs passive scalar turbulence

Active and passive scalars transported by an incompressible two-dimensional conductive fluid are investigated. It is shown that a passive scalar displays a direct cascade towards the small scales while the active magnetic potential builds up large-scale structures in an inverse cascade process. Correlations between scalar input and particle trajectories are found to be responsible for those dramatic differences as well as for the behavior of dissipative anomalies.Comment: Revised version, Phys. Rev. Lett., in pres