Of cyclones, tsunamis, and the engaged anthropologist: Some musings on colonial politics in the Andaman Islands

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MALDI-TOF MS Based Proteomic Fingerprinting of Total Serum Plasma for Somatic Pain Syndromes

There are racial and ethnic disparities regarding pain management within the United States, and that disproportionately affects women of color. There is also a fundamental lack of information regarding the biological mechanism by which pain sensitization and perception occurs, and how it could be affected by both neurologic and somatic pain syndromes. Methods: Research was performed on principal electronic scientific databases including Google Scholar, PubMed, and Embase with search terms “MALDI-TOF”, “ESI-MS”, “Pain”, and “Biomarkers”, as well as other modifiers to narrow the literature search. Results: Studies on comparison between MALDI-TOF and other traditional analysis platforms, including Electrospray Ionization (ESI-MS), proteomic characterization of biomarkers related to pain, classification of disease states based on global analysis of spectrograms, disparities between racial and ethnic groups regarding pain medication prescription, workflow pipelines regarding biomarker isolation and characterization, and potential biomarkers specific to somatic and neurologic pain symptoms (Cancer, Psychiatric Sensitization, Osteoarthritis, Fibromyalgia) and general inflammation have been presented and commented on. Conclusion: This overview supports the view that MALDI-TOF has demonstrated high utility in detecting, selecting, and characterizing biomarkers relating to pain symptoms and pain-inducing conditions, compared to more traditional methods, with greater sequence coverage during proteomic analysis, specificity, and sensitivity. Additionally, the MALDI-TOF platform can be used both clinically and experimentally to describe the biomolecular basis of disease progression. This platform can be used clinically as an objective measure of pain and pain sensation to guide clinical treatment and reduce medical care inequality for marginalized groups and individuals

The Correlation Between Serum C-Reactive Protein Level and Risk of Future Cardiovascular Disease: A Neurodivergent Population Dilemma

Extensive research on neurotypical (NT) populations has demonstrated that a chronically elevated level of serum C Reactive Protein (CRP) is a strong predictor of future cardiovascular disease (CVD). Interestingly, many neurodivergent (ND) populations experience chronically elevated CRP levels higher than NT controls. Current research is concerned with establishing the significance of this relationship to accurately predict CVD risk for potentially at risk ND patients. To contribute to this gap in knowledge, the Rowan-Virtua Regional Integrated Special Needs (RISN) Center patient population will be studied to identify trends in baseline serum CRP levels across a multitude of ND conditions. A clinical risk assessment scale, specifically designed for treating ND populations, will be developed based on the significance of the results of this study

Threats –Solutions in Cloud security

Distributed computing frameworks speak to a standout amongst the most complex processing frameworks as of now in presence. Current uses of Cloud include broad utilization of disseminated frameworks with shifting level of network and use. With a late concentrate on huge scale expansion of Cloud processing, personality administration in Cloud based frameworks is a basic issue for the maintainability of any Cloud-based administration. This zone has additionally gotten extensive consideration from the exploration group and also the IT business. Diverse calculations and methodology are utilized by the specialists. Still distributed computing security is in its center stage. A few IT organizations are concentrating on cloud security and cloud information security. This paper gives a thought regarding security dangers and arrangements

Perinatal Experiences of People with Autism Spectrum Disorders: A Preliminary Scoping Review

Autism Spectrum Disorder (ASD) is a developmental disorder that is diagnosed in early childhood, typically in people who are assigned male at birth. However, this diagnosis and the sensory and behavioral divergence that comes with ASD stay with people throughout their lives. Based on the DSM-V diagnostic criteria and the history of how Autism and Autism Spectrum Disorders were first identified, many people who do not identify as male and/or present atypically do not receive a formal diagnosis until later in life or self-diagnose. This in turn has led to a lack of research in both populations that do not identify as cisgender male and in adult healthcare for people with ASD. This preliminary scoping review focuses on the perinatal (pregnancy, birth, and postnatal) experiences of people with Autism Spectrum Disorders. Currently there are very limited quantitative and qualitative studies exploring this topic and there are significant gaps in provider knowledge of atypical and/or adult presentations of ASD. In this review, I looked at papers published in English and available through the PubMed database that focused on one of the following three themes: perinatal experiences of the ASD population, healthcare experiences in general of the ASD population, and perinatal experiences of people with disabilities in general. After performing a scoping review of 6 papers, most people with ASD had increased sensitivity to sensory and physical stimuli during pregnancy, felt unprepared to address their body’s signals during birth, and unprepared to cope with the physical postnatal symptoms and sensory sensitivities associated with breastfeeding. Surprising to note was that many parents with ASD felt that their increased sensory sensitivities strengthened their response to the baby’s cues. All these sensory/physical experiences went unrecognized for the most part by physicians as the patients with ASD felt pressure to act in a socially normative way and many did not disclose their diagnosis to the physician whether due to a lack of formal diagnosis and/or due to fear of a negative impact on their healthcare interactions. This lack of disclosure and masking of behaviors led to patient needs being underestimated by the healthcare team and the development of multiple communication barriers such as lack of adjustment to patient needs whether it be via providing an advocate or different methods of providing information. These barriers highlighted the gaps in physician knowledge on how ASD is a spectrum and has many different manifestations and their ignorance in how to properly address and adapt to patient symptoms of meltdown/shutdown/sensory overload. Participants in all the papers reviewed emphasized that continuity of care and physician willingness to adjust to patient needs contributed to improved health outcomes. Recommendations made for medical training and physicians included increased training on ASD, diversity in how information is provided, and adjusting to individual patient needs. However, current research is very limited and most had multinational or populations outside of the USA in their studies. Future studies must focus on elucidating barriers specific to the USA and gauging physician knowledge of ASD and their perceptions of that population

The Vaginal Microbiome Post-Menopause and Urinary Tract Infections

Background: Urinary Tract Infection (UTI) is a condition where pathogens invade the urinary tract and can travel up the urethra and into the bladder. UTIs occur more commonly in females compared to males and in the post-menopausal population this rate increases significantly. While these infections may be asymptomatic, they can also cause severe discomfort and lead to serious and even life threatening complications. Recent investigation into the vaginal microbiome has opened the doors to a possible mechanism behind the increased incidence of UTIs after menopause. Understanding the pathogenesis behind the increased risk of UTIs in the postmenopausal state will allow for improved prevention and treatment of UTIs in this population. Methods: This literature review utilized PubMed and Embase as primary databases. Search terms included: vaginal microbiome, urinary tract infections, post-menopause, UTI complications, antibiotic resistance, estrogen replacement therapy, Lactobacillus, topical estrogen, estrogen replacement therapy, and probiotics. Results: This review found that the decreased levels of estrogen are associated with lower levels of Lactobacilli, an immunoprotective bacteria in the vaginal microbiome, and that this decrease in Lactobacilli contributes to increased susceptibility to invasion by pathogens. While methods to restore Lactobacilli levels lack an abundance of research, the current literature indicates that methods such as estrogen replacement therapy and probiotics targeting the vaginal microbiome in the post-menopausal state hold promise for the improvement of care and prevention of UTIs . Conclusion: Further research into the efficacy of treatment modalities such as estrogen replacement therapy and probiotics is needed in order to better understand the mechanisms by which they improve the vaginal microbiome as well as the impact they would have on lowering the rates of UTIs and associated complications in the postmenopausal population

Perception of Teachers and Students towards the Implementation of Choice Based Credit System at Undergraduate Level

The present study examines the perception of teachers and students of undergraduate colleges towards the implementation of Choice Based Credit System (CBCS) by investigating the significance of difference in the perception of teachers in relation to stream and students in relation to sex, streams and types of colleges. For this purpose near about 60 teachers and 120 students were selected through random sampling from 4 undergraduate colleges of Bargarh district affiliated to Sambalpur University, Odisha. The descriptive survey method was used by the researchers. The data were collected through five point perception scale developed by the researchers for teachers and students separately. For the analysis of the obtained data test was used. The result indicated that arts, science and commerce teachers did not differ significantly in their perception towards implementation of CBCS at undergraduate level. The science students differed significantly from the commerce and arts students in their perception towards the implementation of CBCS at undergraduate level. But arts and commerce students did not differ significantly in their perception. There was no significant difference in the perception of male and female students. The students of Government College differed significantly from the students of private college and government aided colleges in their perception towards the implementation of CBCS at under graduate level

Healthcare Disparities in the LGBTQIA+ Community: A Scoping Review of Community vs Provider Experiences

Background: It is well-established that healthcare disparities exist in the LGBTQIA+ community. The divide is a growing concern exacerbated by recent changes in the healthcare and sociopolitical climate. To eliminate this divide and find ways to deliver better outcomes to the LGBTQIA+ is a dire need. This report analyzes the possible reasons from the community as well as the providers perspective, with a goal to find best practices that could be implemented in both components. Methods: A scoping literature review was carried out as described below to collect perspectives from both sides: patients as well as providers. Results: From patient experiences, positive experiences include affirmation, collaborative interaction and inclusive approach; negative experiences were lack of resources/knowledge, insensitive and less-than-adequate care and loss of trust. From the provider perspective, major problems were due to the attitude, rooted in bias created by heteronormative beliefs. TNB, bisexual and lesbian patients are, very often, most affected by these attitudes. These were exacerbated by lack of preparation and training from UME through residency. Conclusions: Training programs with dedicated hours through all levels and implementation of affirming language are suggested as first steps