295 research outputs found

    Zwey Buecher Theophrasti Paracelsi des erfar, nesten ... von der Pestilentz und ihren ZĆŻfaellen / durch ... Adamen von Bodenstein, in Druck verfertiget ...

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    https://digitalcommons.wustl.edu/paracelsus/1011/thumbnail.jp

    Transcriptional Profiling of the Dose Response: A More Powerful Approach for Characterizing Drug Activities

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    The dose response curve is the gold standard for measuring the effect of a drug treatment, but is rarely used in genomic scale transcriptional profiling due to perceived obstacles of cost and analysis. One barrier to examining transcriptional dose responses is that existing methods for microarray data analysis can identify patterns, but provide no quantitative pharmacological information. We developed analytical methods that identify transcripts responsive to dose, calculate classical pharmacological parameters such as the EC50, and enable an in-depth analysis of coordinated dose-dependent treatment effects. The approach was applied to a transcriptional profiling study that evaluated four kinase inhibitors (imatinib, nilotinib, dasatinib and PD0325901) across a six-logarithm dose range, using 12 arrays per compound. The transcript responses proved a powerful means to characterize and compare the compounds: the distribution of EC50 values for the transcriptome was linked to specific targets, dose-dependent effects on cellular processes were identified using automated pathway analysis, and a connection was seen between EC50s in standard cellular assays and transcriptional EC50s. Our approach greatly enriches the information that can be obtained from standard transcriptional profiling technology. Moreover, these methods are automated, robust to non-optimized assays, and could be applied to other sources of quantitative data

    Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

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    This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

    Vom Wirken berĂŒhmter Ärzte aus vier Jahrhunderten

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    UniversitĂ  degli Studi di Triest

    Philosophia Mystica : Darinn begriffen Eilff unterschidene Theologico-Philosophische, doch teutsche TractĂ€tlein, zum theil auß Theophrasti Paracelsi, zum theil auch M. Valentini Weigelii, ...

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    Layoutgetreues Digitalisat der Ausg.: Newstadt : Jenes, 1618 Standort: UniversitĂ€t Marburg, Bibliothek Religionswissenschaft Signatur: 268 Bemerkungen: Vollst. Titel: Philosophia Mystica : Darinn begriffen Eilff unterschidene Theologico-Philosophische, doch teutsche TractĂ€tlein, zum theil auß Theophrasti Paracelsi, zum theil auch M. Valentini Weigelii, ... bißhero verborgenen manuscriptis der Theologischen Warheit liebhabern ; An jtzo in zweyen Theilen ... in offenen Truck gegebe (Bibliothek Wittgenstein
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