Simulation experiments for performance analysis of multiple-bus multiprocessor systems with nonexponential service times

A simulation model (program) is constructed for performance analysis of multiple-bus multiprocessor systems with shared memories. It is assumed that the service time of the common memory is either hypo- or hyperexponentially distributed. Process ing efficiency is used as the performance index. To investigate the effects of different service time distributions on the system perfor mance, comparative results are obtained for a large set of input parameters. The simulation results show that the error in approx imating the memory access time by an exponentially distributed random variable is less than 6% if the coefficient of variation is less than 1, but it increases drastically with this factor if it is greater than 1.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68518/2/10.1177_003754978905200104.pd

The opto-mechanical design of the GMT-Consortium Large Earth Finder (G-CLEF)

The GMT-Consortium Large Earth Finder (G-CLEF) will be part of the first generation instrumentation suite for the Giant Magellan Telescope (GMT). G-CLEF is a general purpose echelle spectrograph operating in the optical passband with precision radial velocity (PRV) capability. The measurement precision goal of G-CLEF is 10 cm/sec; necessary for the detection of Earth analogues. This goal imposes challenging stability requirements on the optical mounts and spectrograph support structures especially when considering the instrument's operational environment. G-CLEF's accuracy will be influenced by changes in temperature and ambient air pressure, vibration, and micro gravity-vector variations caused by normal telescope motions. For these reasons we have chosen to enclose G-CLEF's spectrograph in a wellinsulated, vibration-isolated vacuum chamber in a gravity invariant location on GMT's azimuth platform. Additional design constraints posed by the GMT telescope include; a limited space envelope, a thermal leakage ceiling, and a maximum weight allowance. Other factors, such as manufacturability, serviceability, available technology, and budget are also significant design drivers. G-CLEF will complete its Critical Design phase in mid-2018. In this paper, we discuss the design of GCLEF's optical mounts and support structures including the choice of a low-CTE carbon-fiber optical bench. We discuss the vacuum chamber and vacuum systems. We discuss the design of G-CLEF's insulated enclosure and thermal control systems which simultaneously maintain the spectrograph at milli-Kelvin level stability and limit thermal leakage into the telescope dome. Also discussed are micro gravity-vector variations caused by normal telescope slewing, their uncorrected influence on image motion, and how they are dealt with in the design. We discuss G-CLEF's front-end assembly and fiber-feed system as well as other interface, integration and servicing challenges presented by the telescope, enclosure, and neighboring instrumentation. This work has been supported by the GMTO Corporation, a non-profit organization operated on behalf of an international consortium of universities and institutions: Arizona State University, Astronomy Australia Ltd, the Australian National University, the Carnegie Institution for Science, Harvard University, the Korea Astronomy and Space Science Institute, the São Paulo Research Foundation, the Smithsonian Institution, the University of Texas at Austin, Texas AM University, the University of Arizona, and the University of Chicago

Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet’ a major step forward

Markovian Queueing Network Models for Performance Evaluation of Multiple-Bus Multiprocessor Systems.

A closed-form solution for the performance analysis of multiple-bus multiprocessor systems is presented. A Markovian queueing network model has been developed to investigate the effects of memory and bus contentions on the multiprocessor system performance. The symmetrical structure of the Markov chains of the queueing network model makes it possible to demonstrate that local balance is satisfied. Consequently, the steady-state probabilities of the states of the Markov chains can be expressed by simple formulas. Processing efficiency is used as a primary performance measure and its relationship with the other performance measures are established. To investigate the effects of the system design parameters on the multiprocessor system performance, comparative results have been obtained for a large family of multiprocessor configurations from unibus to bus-sufficient systems. The simulation results show that if the st and ard deviation of the service time of the common memory does not differ too much from its mean value, then the error produced by the assumption of exponential distribution is in an acceptable range.Ph.D.Computer scienceUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/160576/1/8512481.pd

Feedback control of many differential-drive robots with uniform control inputs

We describe a method of feedback position control for an ensemble of robots with unicycle kinematics under the constraint that every robot receives ex- actly the same global control inputs. Each robot in the ensemble scales its given control inputs by a bounded model parameter and thus may achieve a turning rate and forward speed which are unique. Exploiting inhomogeneities in robot execution of control inputs, we derive a globally asymptotically sta- bilizing feedback control policy to regulate the position of each robot. This policy scales linearly for any number of robots, and it stabilizes the system asymptotically to the goal position even with Gaussian noise in actuation. Computer simulations and hardware experiments are used to validate the pol- icy. Additionally, we propose methods for trajectory tracking and obstacle avoidance. Finally, we show an example of multi-robot object manipulation and assembly

Development of Co-solvent Freeze-Drying Method for the Encapsulation of Waterinsoluble Thiostrepton in Sterically Stabilized Micelles

The purpose of this work was to develop a practical and scalable method to encapsulate the hydrophobic antibiotic thiostrepton (TST) in sterically stabilized micelles (SSM). Using the conventional method of thin-film hydration, we encapsulated up to 5 drug molecules per SSM (diameter ~16nm). However, since this method is not suitable for large-scale production – a limiting factor for clinical translation – we applied the co-solvent freeze drying method using tertbutanol (TBA): water co-solvent system. We found that the presence of phosphate buffered saline (PBS) salts in the lyophilized cake accelerated the reconstitution time and allowed efficient drug encapsulation without the formation of larger drug particles. In addition, TBA proportion of 50% (v/v) was sufficient to maintain both phospholipid and drug in solution prior to the freeze-drying. The increase of drug and phospholipid concentrations in the formulation extended the reconstitution time and led to drug precipitation. Therefore, to increase the strength of the formulation, we prepared lyophilized cakes with lower phospholipid content (5mM) and reconstituted them in one-third of the fill volume. In conclusion, we found optimum conditions to prepare TST-SSM using the co-solvent freeze-drying method. This scalable the freeze-drying. The increase of drug and phospholipid concentrations in the formulation extended the reconstitution time and led to drug precipitation. Therefore, to increase the strength of the formulation, we prepared lyophilized cakes with lower phospholipid content (5mM) and reconstituted them in one-third of the fill volume. In conclusion, we found optimum conditions to prepare TST-SSM using the co-solvent freeze-drying method. This scalable production method can facilitate the further clinical development and industrial production of TST-SSM nanomedicine

Cytotoxic, Apoptotic and Genotoxic Effects of Lipid-Based and Polymeric Nano Micelles, an In Vitro Evaluation

Self-assembly systems (SAS) mainly consist of micelles, and liposomes are the classes of Nano Drug Delivery Systems with superior properties compared to traditional therapeutics in targeting cancer tumors. All commercially available nano-formulations of chemotherapeutics currently consist of SAS. According to our knowledge, a specific toxicity comparison based on material differences has not yet been performed. The purpose of this study was to evaluate and compare the toxicity of two SAS consisting of Sterically Stabilized Micelles (SSM) made of a lipid-based amphiphilic distearoyl-sn-glycero-phosphatidylethanolamine-polyethylene glycol (PEG)-2000 and a polymeric micelle (PM) consisting of Y-shape amphiphilic block copolymer, synthesized using poly ε-caprolactone and PEG. The mechanism of cytotoxicity and genotoxicity of micelles on L-929 healthy mouse fibroblast cells was assessed using Sulforhodamine-B, WST-1, Acridine Orange/Ethidium Bromide and alkaline single-cell gel electrophoresis assays. Results showed that SSM in conc. of 40 mg/mL shows very low cytotoxicity at the end of 24, 48 and 72 h. The DNA damage caused by SSM was much lower than PM while the latter one showed significant toxicity by causing apoptosis with the ED50 value of 3 mg/mL. While the DNA damage caused by SSM was ignorable, some DNA chain breaks were detected on cells treated with PM

Controlling Many Differential- Drive Robots with Uniform Control Inputs

This paper derives both open-loop and closed-loop control policies that steer a finite set of differential-drive robots to desired positions in a two-dimensional workspace, when all robots receive the same control inputs but each robot turns at a slightly different rate. In the absence of perturbation, the open-loop policy achieves zero error in finite time. In the presence of perturbation, the closed-loop policy is globally asymptotically stabilizing with state feedback. Both policies were validated with hardware experiments using up to 15 robots. These experimental results suggest that similar policies might be applied to control micro- and nanoscale robotic systems, which are often subject to similar constraints