79,147 research outputs found

    Strengthening the ties that exist: Reexploring charted territory

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    published or submitted for publicationis peer reviewe

    Assessing the impact of non-additive noise on modelling transcriptional regulation with Gaussian processes

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    In transcriptional regulation, transcription factors (TFs) are often unobservable at mRNA level or may be controlled outside of the system being modelled. Gaussian processes are a promising approach for dealing with these difficulties as a prior distribution can be defined over the latent TF activity profiles and the posterior distribution inferred from the observed expression levels of potential target genes. However previous approaches have been based on the assumption of additive Gaussian noise to maintain analytical tractability. We investigate the influence of a more realistic form of noise on a biologically accurate system based on Michaelis-Menten kinetics

    Quantum Loop Modules and Quantum Spin Chains

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    We construct level-0 modules of the quantum affine algebra \Uq, as the qq-deformed version of the Lie algebra loop module construction. We give necessary and sufficient conditions for the modules to be irreducible. We construct the crystal base for some of these modules and find significant differences from the case of highest weight modules. We also consider the role of loop modules in the recent scheme for diagonalising certain quantum spin chains using their \Uq symmetry.Comment: 32 pages, 5 figures (appended), ENSLAPP-L-419/93, MRR2/9

    Literature, planning and infrastructure: Investigating the southern city through postcolonial texts

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    This article explores the ways in which postcolonial literary and other cultural texts navigate, decode and in some cases re-imagine the infrastructures that organize urban life, particularly in the postcolonial cities of Johannesburg, London and Delhi. Readings of Ivan Vladislavić, Mark Gevisser Brian Chikwava, Selma Dabbagh, Rana Dasgupta and Manju Kapur consider the constantly shifting relationship between urban planning, the organization of public space, and various other forms of human intervention, and suggest that the ways in which urban spaces are mapped in creative practice can explore, negotiate and at times disrupt and reconstruct that relationship

    The Herschel Virgo Cluster Survey - I. Luminosity function

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    We describe the Herschel Virgo Cluster Survey (HeViCS) and the first data obtained as part of the science demonstration phase (SDP). The data cover a central 4×4 sq deg region of the cluster. We use SPIRE and PACS photometry data to produce 100, 160, 250, 350 and 500 μm luminosity functions (LFs) for optically bright galaxies that are selected at 500 μm and detected in all bands. We compare these LFs with those previously derived using IRAS, BLAST and Herschel-ATLAS data. The Virgo cluster LFs do not have the large numbers of faint galaxies or examples of very luminous galaxies seen previously in surveys covering less dense environments

    Design Features for the Social Web: The Architecture of Deme

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    We characterize the "social Web" and argue for several features that are desirable for users of socially oriented web applications. We describe the architecture of Deme, a web content management system (WCMS) and extensible framework, and show how it implements these desired features. We then compare Deme on our desiderata with other web technologies: traditional HTML, previous open source WCMSs (illustrated by Drupal), commercial Web 2.0 applications, and open-source, object-oriented web application frameworks. The analysis suggests that a WCMS can be well suited to building social websites if it makes more of the features of object-oriented programming, such as polymorphism, and class inheritance, available to non-programmers in an accessible vocabulary.Comment: Appeared in Luis Olsina, Oscar Pastor, Daniel Schwabe, Gustavo Rossi, and Marco Winckler (Editors), Proceedings of the 8th International Workshop on Web-Oriented Software Technologies (IWWOST 2009), CEUR Workshop Proceedings, Volume 493, August 2009, pp. 40-51; 12 pages, 2 figures, 1 tabl