Brain health in diverse settings : How age, demographics and cognition shape brain function

Peer reviewe

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Peer reviewe

Resting-state EEG Findings in Differentiating Alzheimer's Disease From Amnestic Mild Cognitive Impairment and Healthy Elderly Controls

Objective: We aimed at investigating alterations in Resting-State electroencephalography (rsEEG) patterns of individuals with amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD)

Validity, Reliability and Turkish Norm Values of the Clock Drawing Test for Two Different Scoring Systems

Objective: The clock drawing test (CDT) version with the pre-drawn circle has been widely used in research and clinical practice without standardized Turkish norms. The present study aimed to standardize CDT scores according to the most frequently used scoring methods in the literature (Manos-Wu and Shulman) and to estimate the validity and reliability of both methods

Reconfigurable band-notched compact c-shaped printed antenna for UWB applications

23rd International Seminar/Workshop on Direct and Inverse Problems of Electromagnetic and Acoustic Wave Theory (DIPED) -- SEP 24-27, 2018 -- Tbilisi, GEORGIAWOS:000468985000036In this study, a compact C-shaped printed antenna with reconfigurable band-notched characteristic is designed for ultra-wideband (UWB) operation. The basic structure is a C-shaped radiator with a very small size of 8x8 mm(2) fed by a microstrip transmission line (MTL) with a matching line overall on 8x26 mm(2) substrate under which a portion of 8x26 mm(2) ground conductor is used. The capability of reconfigurable band-notched characteristic is gained by inserting a pin diode between the edges of C-shaped radiator. The antenna design is printed on a double sided copper with FR4 substrate. Based on measured result, the antenna provides an impedance bandwidth of 3.1-12.9 GHz (at VSWR=2) when it operates at ON state (full UWB). At OFF state, it passes the band of 3.0-3.5 GHz and 5.6-11.7 GHz, thus stop the band of 3.5-5.6 GHz corresponding to WIMAX and WLAN standard. Therefore, the proposed UWB antenna stands out over the literature in terms of geometry's simplicity, compactness, near omnidirectional pattern, high efficiency as well as band-notched configurability.IEEE, IEEE Microwave Theory & Tech Soc, IEEE Electron Devices Soc, IEEE Antennas & Propagat Soc, Univ Tphilisensis, Ivane Javakhishvili Tbilisi State Univ, NASU, Pidstryhach Inst Appl Problems Mech & Math, IEEE MTT ED AP Georgia Chapter, IEEE Ukraine Sect W MTT ED AP EP SSC Soc Joint Chapter, IEEE Ukraine Sect, IEEE Elect Packaging Soc, IEEE Solid State Circuits SocDepartment of Scientific Research Fund (Bilimsel Arastirma Projeleri BAP) of Karamanoglu Mehmetbey University [01-M-17]This study is funded by Department of Scientific Research Fund (Bilimsel Arastirma Projeleri BAP) of Karamanoglu Mehmetbey University (Grant No: 01-M-17)

Normalized Theta but Increased Gamma Activity after Acetylcholinesterase Inhibitor Treatment in Alzheimer's Disease: Preliminary qEEG Study

Acetylcholinesterase inhibitors (AChE-I) are the core treatment of mild to severe Alzheimer's disease (AD). However, the efficacy of AChE-I treatment on electroencephalography (EEG) and cognition remains unclear. We aimed to investigate the EEG power and coherence changes, in addition to neuropsychological performance, following a one-year treatment. Nine de-novo AD patients and demographically-matched healthy controls (HC) were included. After baseline assessments, all AD participants started cholinergic therapy. We found that baseline and follow-up gamma power analyzes were similar between groups. Yet, within the AD group after AChE-I intake, individuals with AD displayed higher gamma power compared to their baselines (P < .039). Also, baseline gamma coherence analysis showed lower values in the AD than in HC (P < .048), while these differences disappeared with increased gamma values of AD patients at the follow-up. Within the AD group after AChE-I intake, individuals with AD displayed higher theta and alpha coherence compared to their baselines (all, P < .039). These increased results within the AD group may result from a subclinical epileptiform activity. Even though AChE-I is associated with lower mortality, our results showed a significant effect on EEG power yet can increase the subclinical epileptiform activity. It is essential to be conscious of the seizure risk that treatment may cause

Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes

The objective of this study was to assess the inhibitory effects of six commonly used pesticides, cyhalothrin, cypermethrin, dichlorvos, methamidophos, chlorpyrifos and methylparathion, on the pH regulatory enzyme carbonic anhydrase (CA) of Dicentrarchus labrax (European Seabass) liver (dCA) and bovine erythrocytes (bCA). Results of the study showed that the pesticides displayed quite variable inhibition profiles with KI values ranging from 0.376 to 26.164 M against dCA, and from 1.174 to 53.281 M against bCA. Methyl- parathion was the most effective inhibitor for both enzymes. Overall data show that all of the tested pesticides inhibit both dCA and bCA at low concentrations indicating that indiscriminate use of these pesticides might cause disruption of acid base regulation resulting in animal deaths. Our results also point out that susceptibility to these pesticides varies among CAs from different organisms

Validity, Reliability and Normative Data of The Stroop Test capa Version

Objective: The Stroop test Capa version does not have normative data, despite its extensive use in clinical and research settings to assess executive functions. The aim of the present study was to test the validity and reliability of the Stroop test Capa version and to establish stratified normative data in individuals aged between 18-83 years

Coherence in event-related EEG oscillations in patients with Alzheimer's disease dementia and amnestic mild cognitive impairment

Objectives Working memory performances are based on brain functional connectivity, so that connectivity may be deranged in individuals with mild cognitive impairment (MCI) and patients with dementia due to Alzheimer's disease (ADD). Here we tested the hypothesis of abnormal functional connectivity as revealed by the imaginary part of coherency (ICoh) at electrode pairs from event-related electroencephalographic oscillations in ADD and MCI patients. Methods The study included 43 individuals with MCI, 43 with ADD, and 68 demographically matched healthy controls (HC). Delta, theta, alpha, beta, and gamma bands event-related ICoh was measured during an oddball paradigm. Inter-hemispheric, midline, and intra-hemispheric ICoh values were compared in ADD, MCI, and HC groups. Results The main results of the present study can be summarized as follows: (1) A significant increase of midline frontal and temporal theta coherence in the MCI group as compared to the HC group; (2) A significant decrease of theta, delta, and alpha intra-hemispheric coherence in the ADD group as compared to the HC and MCI groups; (3) A significant decrease of theta midline coherence in the ADD group as compared to the HC and MCI groups; (4) Normal inter-hemispheric coherence in the ADD and MCI groups. Conclusions Compared with the MCI and HC, the ADD group showed disrupted event-related intra-hemispheric and midline low-frequency band coherence as an estimate of brain functional dysconnectivity underlying disabilities in daily living. Brain functional connectivity during attention and short memory demands is relatively resilient in elderly subjects even with MCI (with preserved abilities in daily activities), and it shows reduced efficiency at multiple operating oscillatory frequencies only at an early stage of ADD