113 research outputs found
Lifting the Dusty Veil With Near- and Mid-Infrared Photometry: III. Two-Dimensional Extinction Maps of the Galactic Midplane Using the Rayleigh-Jeans Color Excess Method
We provide new, high-resolution A(Ks) extinction maps of the heavily reddened
Galactic midplane based on the Rayleigh-Jeans Color Excess ("RJCE") method.
RJCE determines star-by-star reddening based on a combination of near- and
mid-infrared photometry. The new RJCE-generated maps have 2 x 2 arcmin pixels
and span some of the most severely extinguished regions of the Galaxy -- those
covered with Spitzer+IRAC imaging by the GLIMPSE-I, -II, -3D, and Vela-Carina
surveys, from 256<l<65 deg and, in general, for |b| <= 1-1.5 deg (extending up
to |b|<=4 deg in the bulge). Using RJCE extinction measurements, we generate
dereddened color-magnitude diagrams and, in turn, create maps based on main
sequence, red clump, and red giant star tracers, each probing different
distances and thereby providing coarse three-dimensional information on the
relative placement of dust cloud structures. The maps generated from red giant
stars, which reach to ~18-20 kpc, probe beyond most of the Milky Way extinction
in most directions and provide close to a "total Galactic extinction" map -- at
minimum they provide high angular resolution maps of lower limits on A(Ks).
Because these maps are generated directly from measurements of reddening by the
very dust being mapped, rather than inferred on the basis of some less direct
means, they are likely the most accurate to date for charting in detail the
highly patchy differential extinction in the Galactic midplane. We provide
downloadable FITS files and an IDL tool for retrieving extinction values for
any line of sight within our mapped regions.Comment: 23 pages, 5 figures, accepted for publication in ApJ
On the evolutionary ecology of symbioses between chemosynthetic bacteria and bivalves
Mutualistic associations between bacteria and eukaryotes occur ubiquitously in nature, forming the basis for key ecological and evolutionary innovations. Some of the most prominent examples of these symbioses are chemosynthetic bacteria and marine invertebrates living in the absence of sunlight at deep-sea hydrothermal vents and in sediments rich in reduced sulfur compounds. Here, chemosynthetic bacteria living in close association with their hosts convert CO2 or CH4 into organic compounds and provide the host with necessary nutrients. The dominant macrofauna of hydrothermal vent and cold seep ecosystems all depend on the metabolic activity of chemosynthetic bacteria, which accounts for almost all primary production in these complex ecosystems. Many of these enigmatic mutualistic associations are found within the molluscan class Bivalvia. Currently, chemosynthetic symbioses have been reported from five distinct bivalve families (Lucinidae, Mytilidae, Solemyidae, Thyasiridae, and Vesicomyidae). This brief review aims to provide an overview of the diverse physiological and genetic adaptations of symbiotic chemosynthetic bacteria and their bivalve hosts
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment
The rise of multiple imputation: a review of the reporting and implementation of the method in medical research
An exploration of mortality risk factors in non-severe pneumonia in children using clinical data from Kenya
Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
Background
Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials.
Methods
We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality).
Findings
Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5–14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4–8·6]; rate ratio 1·37 [95% CI 1·17–1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92–1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95–1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94–1·15]; p=0·45).
Interpretation
Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be considered—eg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy
Causal Discovery from Medical Data: Dealing with Missing Values and a Mixture of Discrete and Continuous Data
A Simple Method That Uses Differential Staining and Light Microscopy To Assess the Selectivity of Wood Delignification by White Rot Fungi
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