Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study

Background: The absence of a uniform and clinically relevant definition of severe postpartum haemorrhage hampers comparative studies and optimization of clinical management. The concept of persistent postpartum haemorrhage, based on refractoriness to initial first-line treatment, was proposed as an alternative to common definitions that are either based on estimations of blood loss or transfused units of packed red blood cells (RBC). We compared characteristics and outcomes of women with severe postpartum haemorrhage captured by these three types of definitions. Methods: In this large retrospective cohort study in 61 hospitals in the Netherlands we included 1391 consecutive women with postpartum haemorrhage who received either ≥4 units of RBC or a multicomponent transfusion. Clinical characteristics and outcomes of women with severe postpartum haemorrhage defined as persistent postpartum haemorrhage were compared to definitions based on estimated blood loss or transfused units of RBC within 24 h following birth. Adverse maternal outcome was a composite of maternal mortality, hysterectomy, arterial embolisation and intensive care unit admission. Results: One thousand two hundred sixty out of 1391 women (90.6%) with postpartum haemorrhage fulfilled the definition of persistent postpartum haemorrhage. The majority, 820/1260 (65.1%), fulfilled this definition within 1 h following birth, compared to 819/1391 (58.7%) applying the definition of ≥1 L blood loss and 37/845 (4.4%) applying the definition of ≥4 units of RBC. The definition persistent postpartum haemorrhage captured 430/471 adverse maternal outcomes (91.3%), compared to 471/471 (100%) for ≥1 L blood loss and 383/471 (81.3%) for ≥4 units of RBC. Persistent postpartum haemorrhage did not capture all adverse outcomes because of missing data on timing of initial, first-line treatment. Conclusion: The definition persistent postpartum haemo

Intestinal healing and tumour invasion: the role of collagenolytic enzymes

Contains fulltext : mmubn000001_169753174.pdf (publisher's version ) (Open Access)Promotores : H. de Boer, J. de Pont en T. Hendriks148 p

Measurement of Color Texture

In computer vision, measurement of image properties such as color or texture is essential. However, existing methods for measuring color and texture in combination are not well-defined neither from a measurement theoretical basis nor from a physical point of view. We propose a solid framework for the local measurement of texture in color images. We give a physical basis for the integration of the well-known Gabor filters, with the measurement of color. Our method implies that the color-texture is measured in the wavelength-Fourier domain. The measurment filter in this domain boils down to a 3D Gaussian, representing a Gabor-Gaussian in the spatial-color domain. We apply a simple segmentation algorithm to illustrate the performance of our proposed color-texture measurement. The derived color-texture filter is demonstrated to be accurate in capturing texture statistics. In addition, the method is compatible with the measurement of grey-value texture

Fluid resuscitation during persistent postpartum haemorrhage and maternal outcome: A nationwide cohort study

Clinical epidemiolog